S ystolic h eart failure treatment with the i f inhibitor ivabradine t rial
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S ystolic H eart failure treatment with the I f inhibitor ivabradine T rial. Selective heart rate reduction with ivabradine unloads the left ventricle in heart failure patients. Reil JC, et al. J Am Coll Cardiol . 2013 Nov 19;62(21):1977-1985. www.shift-study.com.

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S ystolic H eart failure treatment with the I f inhibitor ivabradine T rial

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S ystolic h eart failure treatment with the i f inhibitor ivabradine t rial

  • Systolic Heart failure treatment withthe Ifinhibitor ivabradineTrial

Selective heart rate reduction with ivabradine unloads the left ventricle

in heart failure patients

Reil JC, et al. J Am CollCardiol. 2013 Nov 19;62(21):1977-1985

www.shift-study.com


S ystolic h eart failure treatment with the i f inhibitor ivabradine t rial

Effect of HR reductionwithivabradine on stroke volume and cardiac output in patients withsystolic HF

Cardiac output, ml/min

Stroke volume, ml

P =0.31

P <0.01

P <0.0001

Baseline

Month 8

n=275

Procoralanmaintainscardiac output.

Procoralanincreases stroke volume.

Reil JC, et al. J Am CollCardiol. 2013 Nov 19;62(21):1977-1985

www.shift-study.com


S ystolic h eart failure treatment with the i f inhibitor ivabradine t rial

Ivabradinehas no impact on blood pressure

even in the long term

NS

NS

Baseline

Blood pressure (mmHg)

Month 8

n=275

Reil JC, et al. J Am CollCardiol. 2013 Nov 19;62(21):1977-1985

www.shift-study.com


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