Pb1 differences in mammalian viruses compared to avian
This presentation is the property of its rightful owner.
Sponsored Links
1 / 2

PB1: Differences in Mammalian Viruses Compared to Avian PowerPoint PPT Presentation


  • 36 Views
  • Uploaded on
  • Presentation posted in: General

PB1: Differences in Mammalian Viruses Compared to Avian. 0 0 1 1 1 1 1 1 1 2 2 2 2 2 2 3 3 3 3 3 3 4 4 4 4 4 5 5 5 5 6 6 6 6 6 6 7 5 5 0 1 2 7 7 8 9 0 0 1 1 6 9 2 2 3 6 7 8 0 3 6 7 8 7 8 8 9 2 4 4 5 6 9 4 2 4 8 4 1 5 9 0 5 0 8 2 6 1 8 5 7 6 1 5 3 1 0 4 3 6 6 1 4 6 1 0 5 4 7 1 1

Download Presentation

PB1: Differences in Mammalian Viruses Compared to Avian

An Image/Link below is provided (as is) to download presentation

Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author.While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server.


- - - - - - - - - - - - - - - - - - - - - - - - - - E N D - - - - - - - - - - - - - - - - - - - - - - - - - -

Presentation Transcript


Pb1 differences in mammalian viruses compared to avian

PB1: Differences in Mammalian Viruses Compared to Avian

0 0 1 1 1 1 1 1 1 2 2 2 2 2 2 3 3 3 3 3 3 4 4 4 4 4 5 5 5 5 6 6 6 6 6 6 7

5 5 0 1 2 7 7 8 9 0 0 1 1 6 9 2 2 3 6 7 8 0 3 6 7 8 7 8 8 9 2 4 4 5 6 9 4

2 4 8 4 1 5 9 0 5 0 8 2 6 1 8 5 7 6 1 5 3 1 0 4 3 6 6 1 4 6 1 0 5 4 7 1 1

AvianK K L V K D M E M V K L S S L I R V S N E A R D V R L E R P Q V V S I K A

1918- R - - - - - - - - - - - - - - - - - S D - - - L – I - - - - - M N - - -

Early H1- R - - - N - - - - - - - - - - - - - S D - - - - - - - - - - - I N - - T

R I - - K G I R I M N h r M M R T

Later H1R R I - - - - – V - - - - - I - - - - - D - - - L – I - - - - - M N – R T

I K M I S V

Early H2- - - I - - - - - - - - - - - - - - - S - V K - - - - - - - - - - - - - -

i v

Later H2- - - I - - - - - - - - - N - - - - - S - V K - - - - - - S - - - - T - -

R

Early H3- - - - R - - - - - - V - - - - K - - S - - - - - - - - - - - - - - - - -

m t

Later H3- - - - - - I - - - - V - - - - K I R S - - K - - K – D Q – R - - - - - S

r g

Equine- - - - - N - - - - - - - R - - - - - S D - K - - - - - - - K - - - - - -

Cl.Swine- - - - - - - - - - - - - - - - - - - S D - - - L - I D - - - - - N - - -

R R v g k i N g k n v l H k T v T

New Swine- - - - - - - - - - - - S - - - - - - S - - - - V - - - - - - - - - - - -

R r I i V G K I R – K K i D Q R S


Pb1 f2 alignment

PB1-F2 Alignment

Predicted a-helical regions

Optimal MTS

1

0

2

0

3

0

4

0

5

0

6

0

7

0

8

0

9

0

Avian Eurasian consensusMEQEQDTPWTQSTEHINIQKRGNGQQTQRLEHPNSTRLMDHYLRIMSRVGMHKQIVYWKQWLSLKNPTQGSLKTRVLKRWKLFSKQEWIN.

Avian No. Am. consensus--R-------------------------------L-Q----C--T----D----T-SL-------S---E-------------N----T-. K

1957 H2N2 consensus----------------------S----RK--R--L-Q-------T-NQ-D----TAS------------E-------------N----T-.

Late H2N2 viruses-G-------------T------s----RK--R--L-Q-------T-NQ-D----TAS---------H--E---I---------N----T-.

- G T.

1968 H3N2 consensus--------------------K-S----RK--RP-L-Q----------Q-D----TVS--------------------------N--G-TD.

Late H3N2 viruses-----G---------T------S-R-Q-K-G-—S-RQ----------Q-D----T-S-RP-P----------R-HA--Q---S---G-TD

- F L - .

1918 PB1-F2-G-------IL--G--ST---ED----P----H--------CQKT-NQ-V-P------------RS--PV----------R----H--TS.

WSN/33-G-------IL--G--ST--GED----PK---R------G-CQKT-NQ-V-P---------P--R--ILV--RP------R----H--T.

PR/8/34/MS-G-------IL--G--ST---ED----PK---R------G-CQKT-NQ-V-P------------R--ILVF---------R----H-.

FM/1/47---G-----IL--G--ST--GEG----PK---H--------CQKT-NQ-V-P------------R--ILVF------RQ-R----H--T.

Beijing/56-G-------IL--G--ST--GED----PK---HS-----G-YQKT-NQ-V-P-----.

Fiji/83-G-------I---G--ST--GED----PK---R------G-YQKT-NQ-V-P-----.

Swine/Iowa/1976/31-G----I--IL-----ST---E-----LK---HN.

Swine/Tennessee/26/77-G-------IL.

Swine/Ontario/2/81-G-------IL.

Swine/Colorado/1/77-E-------T----------K-S-------GR----Q----------QAD--NRT-S-------------F----A-----S-N--G-.

Swine/Finistere/2899/82-E-G-----T-----------ES----------SL-------P-T-NQAD------S-R-----------Y---H--R—R------.

Swine/Hong Kong/126/82-E-------T-----T-----ES----------SL-------P-T-NQA-------S-R—H----------------------N----T.

Swine/Cotes d'Armor/84-E-------T-------T--GE-----------SL-------P-T-NQAD------S-R---T-------Y------R—R-------.

Equine/London/73(H7N7)---------IL----T-T---------L----H--IQS-GRC-KT-NQADTP----------P--S-IP-----------RW--R---T

Equine/Tenn/86(H3N8)---------IL----T-T---------L----H--IQS--RF-KT-NQA-TP---------------IPE---I------RW--R---T


  • Login