Carbohydrate utilization during exercise
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Carbohydrate Utilization During Exercise. Are CHO important during exercise?. 1.) Fatigue often associated with CHO depletion. 2.)  CHO,  OAA  Fat metabolism can only support exercise at 50% VO 2 max. 3.) Hypoglycemia associated with liver CHO depletion.

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Are cho important during exercise
Are CHO important during exercise?

  • 1.) Fatigue often associated with CHO depletion.

2.)  CHO,  OAA  Fat metabolism can only support exercise at 50% VO2 max.

3.) Hypoglycemia associated with liver CHO depletion.


Muscle glycogen breakdown during exercise
Muscle glycogen breakdown during exercise

  • Two biggest factors are intensity and duration of exercise

Recruitment order of slow twitch vs. Fast twitch fibers

  • Glycogen use from only exercising muscle

    • 1 leg experiments

    • deltoid vs. vastus lateralis


Regulation of muscle glycogenolysis
Regulation of Muscle Glycogenolysis

-

+

ADP

ATP

  • PFK-1

AMP

H+

Pi

citrate

-Energy state of muscle cell with impact from substrate supply

Phosphorylase

-local factors

-substrate availability

-hormonal regulation


Regulation of muscle glycogenolysis cont
Regulation of Muscle Glycogenolysis (cont.)

Phosphorylase (cont.)

-local factors:

-substrate availability

-hormonal regulation

Local factors:

cytosolic Ca++ - activates phosphorylase kinase

ADP, AMP, Pi - allosteric activators of phosphorylase

-Need for Pi as a substrate for phosphorylase


Regulation of muscle glycogenolysis cont1
Regulation of Muscle Glycogenolysis (cont.)

Substrate availability:

-Glycogen - allosteric activator of phosphorylase

-Plasma FFA FFA glycogen use

FFA glycogen use

-FFA citrate - PFK-1

acetyl-Co-A activates

PDH Kinase  P-PDH

its activity

-Caffeine glycogen use

Corn Oil/Heparin glycogen use

-Plasma Glucose - Hypoglycemia glycogen use


Hormonal regulation
Hormonal Regulation

Hormonal Regulation

Epi/N-Epi via  receptors C-AMP

 - blockade glycogen use

Removal of adrenal medulla glycogen use








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