1 / 113

OPPORTUNISTIC MYCOSES

OPPORTUNISTIC MYCOSES. OPPORTUNISTIC MYCOSIS. MOLD ASPERGILLOSIS ZYGOMYCOSIS YEAST CRYPTOCUCCOSIS CANDIDIASIS. ASPERGILOSIS. Aspergillus Saprophyte Recycling Carbon & Nitrogen Decaying organic material 900 species. ASPERGILOSIS. Opportunistic Human & Animal A.fumigatus A.flavus

Download Presentation

OPPORTUNISTIC MYCOSES

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript


  1. OPPORTUNISTIC MYCOSES

  2. OPPORTUNISTIC MYCOSIS • MOLD • ASPERGILLOSIS • ZYGOMYCOSIS • YEAST • CRYPTOCUCCOSIS • CANDIDIASIS

  3. ASPERGILOSIS • Aspergillus • Saprophyte • Recycling • Carbon & Nitrogen • Decaying organic material • 900 species

  4. ASPERGILOSIS • Opportunistic • Human & Animal • A.fumigatus • A.flavus • A.niger • Conidia 2-3 μInhalation • Nosocomial infection

  5. ASPERGILOSIS • Cystic fibrosis • Immune compromise • Atopic Asthma • Hematological patients

  6. ASPERGILOSIS • Increase • Diagnosis • Antifungal therapy

  7. ASPERGILOSIS • Allergic • Pulmonary • Cutaneous • Disseminated • Miscellaneous • Iatrogenic

  8. Allergic • Asthma • IgE & Eosinophil ( increase) • ABPA • IgE & Eosinophil ( increase) • Alveolitis • Hypersensitivity type III

  9. Pulmonary • Invasive • Lymphoma & Leukemia • Secondary infection • Invasive to vessels Infarction & Dead • Non invasive • Cavity Colonization • Fungus ball (Aspergilloma) • Hemaptosis

  10. Cutaneous • Rare • 1st • Onychomycosis • Burning • IC • 2nd • Dissemination

  11. Disseminated • Brain • Kidney

  12. Miscellaneous • Otomycosis • Keratomycosis • Sinusitis

  13. Iatrogenic • Materials • Instruments • Aero cells • Air conditioner

  14. Pathogenesis & Defense factors • Cell wall • Melanin • Catalase • Fungal metabolites • Super oxide dismutase

  15. Cell wall • Interface • Ag & Enzymes • Protection • Cell wall of Conidia • Cell wall of Hyphae

  16. Cell wall of Conidia • 2 part • Dense pigmented (out) • DHN (Dihydroxy Naphthalene Melanin) • Translucent (in) • Protection • Phagositosis

  17. Cell wall of Hyphae • Component • Β 1-3 glucan • Galactomanan • Chitin • Role • Protection (PMN) • Enzyme (catalase) • Ag (Galactomanan & β1-3 glucan)

  18. Galactomanan • Special for A.fumigatus • Serum, Urine, BAL • Monoclonal Ab

  19. Melanin • Dihydroxy Phenylalanin (DOPA) • Dihydroxy Naphthalene (DHN) • Free radicals

  20. Catalase • Hydrogen peroxide • Expression • Starvation & Sexual reproduction

  21. Fungal metabolites • Toxins • Epithelial damage • Gliotoxin • Fumagilin • Helvolic acid

  22. Super oxide dismutase • Virulence factor • Surveillance • Neu • Mac

  23. Cellular immunity • T cell very important • Gamma INF( first cytokine) • IL4, IL2, TNFα • Cystic fibrosis ABPA • Innate

  24. Laboratory diagnosis • Sampling • Sputum, BAL, Serum, Urine • KOH 10% • ELISA • Dichotomous

  25. Laboratory diagnosis

  26. Laboratory diagnosis

  27. Laboratory diagnosis

  28. Laboratory diagnosis

  29. Serology • ELISA based Ab (galactomann)

  30. Treatment • Amphotricin B • 5 flurocytosin

  31. Zygomycosis • Phycomycosis • Hyphomycosis • Mucormycosis • Rhizopus • R. oryzea, R. arrhizus • Absidia • A. corymbifera ( 42°- 45°) • Mucor

  32. Zygomycosis • Opportunistic • Very dangerous • Acute • Lethal

  33. Zygomycosis • Para nasal sinuses • Lung • Eye • Ear • Skin • Alimentary

  34. Zygomycosis • Diabetic • Blood cancer • Sever burning • Malnutrition

  35. Zygomycosis • Rhinocerbral • Pulmonary • Gastrointestinal • Cutaneous

  36. Rhinocerbral • Diabetic • Nose & Para nasal • Discharge • Black & blood • Eye

  37. Rhinocerbral

  38. Pulmonary • Like the other pulmonary • Pain • Sputum • Aspiration & inhalation • Mucoroma

  39. Gastrointestinal • Diahria • Haematemsis • Peritonitis • Stool (blood) • Malnutrition

  40. Cutaneous • Burning • Rare

  41. Laboratory diagnosis • Sampling • Biopsy • Culture • S • Direct • Ribbon like

  42. Laboratory diagnosis

  43. Laboratory diagnosis

  44. Laboratory diagnosis

  45. Laboratory diagnosis

  46. Treatment • Control • Amphotricin B • Autopsy

  47. YEAST INFECTIONS • Candida • Cryptococcus • Malassezia • Trichosporon • Rhodotorula • Geotricum ( Mold )

  48. CANDIDIASIS • Candida species • Yeast like • True hyphae • Reverse dimorph

  49. CANDIDIASIS • C.albicans • Normal flora • C.glabrata • C.dubliniensis • C.parapsilosis • Nature ( soil ) • Lactobacillus

  50. CANDIDIASIS • Physiologic • Antibiotic • Diabetic

More Related