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Medizinische Hochschule Hannover Carl-Neuberg Straße 1 30625 Hannover Telefon: 0511-532 6760 hoerning.monique@mh-hannove

Lunch 11.45 – 13.00 13.00-13.25 Siveke J. Molecular mechanism of tumor development in a mouse model of pancreatic cancer 13.25-13.50 Bruns C Angiogenesis and metastasis regulating genes in pancreatic cancer 13.50-14.15 Lechel A.

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Medizinische Hochschule Hannover Carl-Neuberg Straße 1 30625 Hannover Telefon: 0511-532 6760 hoerning.monique@mh-hannove

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  1. Lunch 11.45 – 13.00 13.00-13.25 Siveke J. Molecular mechanism of tumor development in a mouse model of pancreatic cancer 13.25-13.50 Bruns C Angiogenesis and metastasis regulating genes in pancreatic cancer 13.50-14.15 Lechel A. Telomerase deletion limits progression of p53-mutant hepatocellular carcinoma with short telomeres in chronic liver disease 14.15-14.40 Müller-Schilling M. Molecular mechanisms of p53/p63 and p73 in hepatocarinogenesis 14.40-15.05 Malek N.P. Control of cell cycle progression and tissue homeostasis by p27 and cyclin E Location: Eibsee Hotel Am Eibsee 1-3D-82491 GrainauPhone: +49-(0)8821-98810 Distance:Grainau: 3 kmGarmisch-Partenkirchen: 11 km München: 97 kmInnsbruck: 68 kmFüssen: 59 km Molecular pathogenesis and experimental therapy of gastrointestinal cancer – 07.March - 09. March 2007 Contact Information Medizinische Hochschule Hannover Carl-Neuberg Straße 1 30625 Hannover Telefon: 0511-532 6760 hoerning.monique@mh-hannover.de Achtung! Farbwechsel des Vordrucks beachten! An diese Stelle keinen Text stellen!

  2. State of the art lecture: Molecular pathways of genomic instability Division of Molecular Biology, The Netherlands Cancer Institute: 15.05-15.45 Jos Jonkers Molecular pathways of genomic instability in cancer formation Coffee break 15.45-16.15 Immunology and Virotherapy 16.15-16.40 Zender L. Impact of senescence on innate immunity in a HCC mouse model 16.40-17.05 Greten T. Role of Tregs and tumor cell death in immunotherapy of HCC 17.05-17.30 Gütgemann I. A new model for antigen recognition in hepatocellular carcinoma: LAPtTA x c- MYC/OVA transgenic mice 17.30-17.55 Becker P. Strategies for immune-intervention 17.55-18.20 Ebert O. Treatment of hepatocellular carcinoma with tumor specific replicating visicular stomatitis virus 18.20-18.45 Kubicka S. Migration and expansion of dendritic cells as a tool for enhanced crosspresentation of tumorantigens by tumorspecific replicating viruses (Viro- Immunotherapy) 19.30-20.00 Walk with torchlight 20.00 Rustic buffet in the Eibsee cottage Friday 9th March Breakfast 7.00-8.00 State of the art lecture: Academic drug development Medical School Hannover and HZI: 8.00-8.15 Malek N.P. Academic drug development for targeted therapy of cancer – part I 8.15-8.30 Kalesse M. Academic drug development for targeted therapy of cancer – part II 8.30-8.45 Frank R. Academic drug development for targeted therapy of cancer – part III New experimental therapies: 8.45-9.10 Mier W. Endoradiotherapeutic procedures as a tool for tumor therapy 9.10-9.35 Ganten T. The promise of Trail – potential and risks of novel anti cancer therapy 9.35-10.00 de Toni E. Sensitising of cancer cells for receptor-mediated apoptosis: new therapeutic approach for HCC Coffee break 10.00-10.30 Molecular biology 10.30-10.55 Breuhahn, K. Dysregulation of FUSE-binding transcription factors in hepatocarcinogenesis 10.55-11.20 Zender L. New mir30RNA libraries and comparative oncogenomics in GI oncology 11.20-11.45 Schneider G. Cell cycle regulation in Pancreatic cancer cells Thursday 8th March Cell biology and metabolism Breakfast 7.30 – 8.00 8.00-8.25 Straub B. A new form of cell contact: cis-E:N-Cadherin hybrids in normal and malignant liver cells 8.25-8.50 Skawran B. Chromatin remodeling and induction of chromosomal instability 8.50-9.15 Kern M. Prostaglandin metabolism in hepatocarcinogenesis 9.15-9.40 Nies A. Localisation and function of transmembrane transporters in HCC 9.40-10.05 Ryschich E. Time laps microscopy for investigation of tumor cell migration Virology 10.05-10.30 Urban S. HepaRG-cells as a tool to study HBV-infection as well as hepatocyte-specific differentiation and polarization processes 10.30-11.00 Bartenschlager R. Strategies of hepatitis C virus replication and persistence Genomics 11.00-11.25 Radlwimmer B. Array-CGH and gene methylation in HCC 11.25-11.50 Geffers R. Role of SNPs in carcinogenesis and cancer therapy 13.50-14.15 Gallmeier E DNA-repair gene alterations as a pharmacogenomic target for the treatment of GI cancer 14.15-14.40 Kolligs F Critical genes for development of colorectal cancer: new therapeutic targets?  14.40-15.05 Singer S. Mikrotubuli destabilising proteins as therapeutic targets for hepatocellular carcinoma Lunch 11.50 – 13.50 Potential therapeutic targets

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