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Featured Article :. Independent Associations of Glucose Status and Arterial Stiffness With Left Ventricular Diastolic Dysfunction.

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Featured article

Featured Article:

Independent Associations of Glucose Status and Arterial Stiffness With Left Ventricular Diastolic Dysfunction

Katja van den Hurk, Ph.D., Marjan Alssema, Ph.D., Otto Kamp, M.D., Ph.D., Ronald M. Henry, M.D., Ph.D., Coen D. Stehouwer, M.D., Ph.D., Yvo M. Smulders, M.D., Ph.D., Giel Nijpels, M.D., Ph.D., Walter J. Paulus, M.D., Ph.D., Jacqueline M. Dekker, Ph.D.

Diabetes Care

Volume 35: 1258-1264

June, 2012


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Study Objectives

  • To investigate relative contributions of glucose status and arterial stiffness to markers of left ventricular (LV) systolic and diastolic dysfunction after 8 years of follow-up

van den Hurk K et al. Diabetes Care 2012;35:1258-1264


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Study Design

  • Population-based prospective Hoorn Study

  • 394 individuals with normal LV systolic and diastolic function participated

  • 87 had impaired glucose metabolism

  • 128 had type 2 diabetes

  • Measurements including arterial ultrasound and echocardiography performed

van den Hurk K et al. Diabetes Care 2012;35:1258-1264


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van den Hurk K et al. Diabetes Care 2012;35:1258-1264


Featured article

van den Hurk K et al. Diabetes Care 2012;35:1258-1264


Featured article

van den Hurk K et al. Diabetes Care 2012;35:1258-1264


Featured article

van den Hurk K et al. Diabetes Care 2012;35:1258-1264


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Conclusions

  • Glucose status and arterial distensibility are independently associated with more severe LV diastolic dysfunction 8 years later and with deterioration of LV diastolic dysfunction

  • Type 2 diabetes and arterial stiffness may relate to LV diastolic dysfunction through different pathways

van den Hurk K et al. Diabetes Care 2012;35:1258-1264


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