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New Sensor Technology: Air Monitoring for Fuel & Naphthalene- Related Risk Management. Janis Hulla, Ph.D., D.A.B.T [email protected] 48 th Annual Navy & Marine Corps Public Health Conf. March 2009.

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New sensor technology air monitoring for fuel naphthalene related risk management l.jpg

New Sensor Technology:Air Monitoring for Fuel & Naphthalene- Related Risk Management

Janis Hulla, Ph.D., D.A.B.T

[email protected]

48th Annual Navy & Marine Corps Public Health Conf.

March 2009

Opinions expressed are my own and do not necessarily reflect the policy of the Army Corps of Engineers, the Army or DOD.


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Topics To Be Presented

  • The Naphthalene Impact Assessments

    • Scan-Watch-Action

  • The Naphthalene Dosimeter SBIR Project

    • Application of sensor technology to develop a real-time exposure monitor

  • The Naphthalene Dosimeter Validation Project

    • Part 1: Independent validation of the prototype’s performance

    • Part 2: Transform the exposure monitor into a dosimeter


Topic 1 the naphthalene impact assessments l.jpg

Topic #1 The Naphthalene Impact Assessments


Here is why naphthalene s on the action list l.jpg

RMOs to GC

Source: CMRM Directorate

Here is Why Naphthalene’s on the “Action List”

Cal OSHA: Newly recommended OEL is 13x lower & based on non-cancer endpoint

EPA: Naphthalene may be reclassified as “likely” human carcinogen (NTP Results).

29CFR 1910.1200: If carcinogen content greater than 0.1%, the substance is considered a carcinogenic hazard.

Naphthalenes are a 1-3 % component of JP8 and DOD’s annual JP8 consumption approximately 5 billion gallons.

NRC-2002: JP8 is likely the single largest chemical exposure war fighters experience.


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Naphthalene State of the Science Meeting, 10/06

*

*

FY06 FY07 FY08 FY09 FY10 FY11

Naphthalene Phase I Impact Assessments (Noblis & CTC)

Naphthalene Phase II Impact Assessment


How the information flows l.jpg

NIOSH IDLH

Lowest Observable Adverse Effect Level (LOAEL)

NIOSH &ACGIH STELs

NIOHS-RELOSHA- PEL

Concentration: mg/m3

Ref. Conc. (RfC)

Source: www.epa.gov/ttn/atw/hlthef/naphthal.html

How the Information Flows

Nat’l Tox. Prog.

EPA drafts Cancer Tox. value

DOD anticipates regulatory Changes

Phase I impact assessment

Toxicity Values Reg. & Advisory #s

The DOD doesa more rigorous Phase II impact assessment & develops risk management options.


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New Naphthalene Regulation?Anticipated Impacts to DOD functions

  • Occupational Health

    • Fuel related exposures

  • Production, Operations, Maint. & Disposal of Assets

    • Newly identified air pollution

  • Readiness & Training

    • Increased fuel costs

  • Acquisitions-RDT&E

  • Environmental Restoration

    • Cleanup of sites w/ fuel…newly identified cancer risk & increase in Cost-to-Complete


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Evolving Occupational Regulation: Anticipated ESOH impact

PEL, 50 mg/m3

Cal-OSHA’s recommended OEL is 3.9 mg/m3

X


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Anticipated Cleanup Program Impact

Nat’l Tox. Prog.

EPA drafts Naphthalene Risk Assessment

Toxicity Values

Lowest Observable Adverse Effect Level (LOAEL)

Concentration: mg/m3

New cancer potency factor?

(TBD, 2011)

Ref. Conc. (RfC)

Source: www.epa.gov/ttn/atw/hlthef/naphthal.html


Naphthalene phase ii assessment l.jpg
Naphthalene Phase II Assessment

RMOs to GC

Source: CMRM Directorate

  • QUANTITATIVE Impact Assessment

  • Objectives:

  • risk management options

  • strategic investment options


Topic 2 the naphthalene dosimeter sbir project l.jpg

Topic #2The Naphthalene Dosimeter SBIR Project


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Dosimeter SBIR Project Goal

  • Develop a naphthalene dosimeter as a tool to manage naphthalene-related health risks.

  • Apply new sensor technology to develop a real-time naphthalene dosimeter.

    • naphthalene-specific and quantitative

    • detection concentrations as low as 0.1 mg/m3

    • audible alert signal at Immediate Danger to Life/Health

    • electronic logging of exposure over time, e.g., work shift

    • cell phone size

    • durable in cold, hot, humid and dusty environments


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The Naphthalene Dosimeter Advisory Group formed 12/07, formally charter 7/08

Naphthalene State of the Science Meeting, 10/06

The dosimeter project was initiated soon after the EPA’s 2005 draft Risk Assessment.

SBIR Dosimeter

Concept Proposed 11/06

SBIR

Solicited

6/07

SBIR Phase I

Awarded 12/07

SBIR Phase II Award 12/08

*

FY06 FY07 FY08 FY09 FY10 FY11

1st Phase IImpact Assessment


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The Naphthalene Dosimeter Advisory Group- formally charter 7/08

Janis Hulla, PhD, DABT (Chair)

Senior Toxicologist, Sacramento Dist.

U.S. Army Corps of Engineers


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The Naphthalene Dosimeter SBIR Project formally charter 7/08

  • Funded by the Army Research Office

    • 2 SBIR Phase I contracts award in FY08, $75,000 each

    • 1 Phase II contract awarded for FY09-10, $750,000

  • The SBIR Phase II Contractor

    • Photon Systems, Covina, CA, William Hug, PhD, CEO.

  • Army Research Office Project Manager

    • Micheline Strand, PhD (Army Research Office)

  • Project Science Manager

    • Janis Hulla, PhD, DABT (USACE-SPK)

      • funded by ARO and USACE’s FUDS & EMCX


Exposure to petroleum based fuels the single largest chemical exposure war fighters experience l.jpg
Exposure to Petroleum-Based Fuels formally charter 7/08The single largest chemical exposure war fighters experience.

Naphthalene Dosimeter SBIR Project

Risk Management Options


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Current Naphthalene Reg./Advisory Levels formally charter 7/08

1,310 mg/m3 IDLH

.

50 mg/m3 PEL

.

Range targeted for the Naphthalene Dosimeter capability

.

Cal- OSHA’s recommended OEL is 3.9 mg/m3.

X



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DODs’ Concept: formally charter 7/08Fuel Handling Deployments


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Naph. mg/m formally charter 7/083

Spectrometer

Naph. mg/m3Prototype Dosimeter

Assessing Performance of the PrototypesExposure Chamber Experiments

  • Photon Systems Inc. uses:

  • Hot/Cold finger for introduction of known vapor pressure of jet fuel, Naphthalene, & maybe other fuel components

  • Deep UV absorption spectrometer inside chamber for secondary calibration of vapor pressure


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Topic #3 formally charter 7/08

The Naphthalene Dosimeter Validation

Part 1Independently validate the performance

Part 2Transform a prototype exposure monitor into a dosimeter


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SBIR formally charter 7/08

Proposed

9/06

SBIR

Solicited

6/07

SBIR Phase I

Awarded 12/07

Validation Study, Part 1

SBIR Phase I

Evaluated for Phase II award

9-11/08

SBIR Phase II Award 12/08

FY06 FY07 FY08 FY09 FY10 FY11

DOD-funded Validation Project Part 2

NIOSH investigator submitted proposals for NIOSH funding, 3/09

Temple University Exposure Chamber Proposal

Submitted ?/09


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Naph. mg/m formally charter 7/083

Spectrometer

Validation Study, Part 1Investigators and Goals

  • Rominder Suri, PhD, Temple University, Civil & Environmental Engineering

    • Independently validate prototype dosimeter performance: Sensitivity & Selectivity,

    • Define performance environmental parameter: Temperature, Humidity, Dust

    • DOD is the customer.

  • John Snawder, PhD, DABT, Biomonitoring Team, submitted a proposal

    • The Commercial Transportation Sector is the customer, i.e., NIOSH-Funded.

Naph. mg/m3Prototype Dosimeter


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Topic #3 formally charter 7/08

The Naphthalene Dosimeter Validation

Part 1 Independently validate the performance

Part 2Transform a prototype exposure monitor into a dosimeter


Slide25 l.jpg

SBIR formally charter 7/08

Proposed

9/06

SBIR

Solicited

6/07

SBIR Phase I

Awarded 12/07

SBIR Phase I

Evaluated for Phase II award

9-11/08

SBIR Phase II Award 12/08

FY06 FY07 FY08 FY09 FY10 FY11

DOD-funded Validation Project Part 2

NIOSH Exposure Chamber Proposal Submitted to NIOSH 3/09

Temple University Exposure Chamber Proposal

Submitted ?/09


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Validation: Naphthalene Biomarkers formally charter 7/08

  • Funding from the CMRM Directorate, OSD/OUSD (I&E)

    • $110,000, contract awarded to Army Research Office for FY09

      • Develop Protocol, Institutional Review Board Approval, Recruit Fuel Handlers

  • Principal Investigator

    • Janis Hulla PhD, DABT, Toxicologist, Army Corps of Engineers-SPK

  • Co-Principal Investigators

    • John Snawder, PhD, DABT

      • NIOSH, Biomonitoring Team Leader

    • Susan Proctor, DSc

      • Epidemiologist, Army Research Institute of Environmental Medicine

    • Micheline Strand, PhD: Project Management

      • Life Sciences Division Chief, Army Research Office


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Others Involved with the Validation Project formally charter 7/08

  • CMRM Directorate, Project Manager

    • Paul Yaroschak, PE, Deputy Director

  • The CDC Foundation

  • Allan Buckpitt, PhD, UC-Davis

    • Collaborating Scientist in FY10

      • Urine Metabolites/Adducts, Nasal Epithelium Adducts, P450 Activity and/or Expression


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Naph. mg/m formally charter 7/083Conventional

Naph. mg/m3Prototype

Field Validationof the prototype exposure monitor

How does the new technology compare to conventional technology?

?


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formally charter 7/08

Risk Management Options

Naphthalene Dosimeter SBIR

First Goal to be realized: Assurance of occupational health protection.


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The 1 formally charter 7/08St Prototype is an Exposure Monitor.Here’s how we’re going to make it into a dosimeter:A DOD-Funded project that correlates environmental exposure with human biomarkers of exposure.


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F(x): formally charter 7/08Naphthalene exposure biomarkers to [Naph. in Air]?

Naph. Biomarkers

Naph. mg/m3(Prototype)

Making it a Dosimeter


Slide32 l.jpg

Making it a formally charter 7/08Dosimeter

  • Urine metabolite/adduct biomarkers will inform:

  • PBPK models

  • Mode of Action

By permission of Dr. Buckpitt.


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By permission of Dr. Buckpitt. formally charter 7/08

Making it a Dosimeter

  • Enzyme activity, expression (& adduct) biomarkers will inform:

  • PBPK models

  • Mode of Action

  • Biologically Based Dose-Response Model


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From: Env Health Perspect, Vol 115, No 6, June 2007, PBTK Modeling Demonstrates Contribution of Dermal and Inhalation Exposure Components to End-Exhaled Breath Concentrations of Naphthalene, Kim, et al.

Making it a Dosimeter

Dermal, Exhaled Air & Urine Metabolite/Adduct

analytical data will inform the PBPK & BBDR Models.

Prototype Dosimeter Data


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2 Modeling Demonstrates Contribution of Dermal and Inhalation Exposure Components to End-Exhaled Breath Concentrations of Naphthalene, Kim, et al. nd Goal to be realized: Address Risks to Cleanup programs

IRIS


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[naph] T Modeling Demonstrates Contribution of Dermal and Inhalation Exposure Components to End-Exhaled Breath Concentrations of Naphthalene, Kim, et al. 1

[naph] T2

Vapor Intrusion

Potential Future Direction: Cleanup

Apply the naphthalene sensor to measure flux across the vadose zone.


Potential future direction esoh l.jpg

RESPONSE Modeling Demonstrates Contribution of Dermal and Inhalation Exposure Components to End-Exhaled Breath Concentrations of Naphthalene, Kim, et al.

DOSE

Potential Future Direction: ESOH

Epidemiology Study?

Health Effects Data Gap?


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Potential Future Direction: Operations Modeling Demonstrates Contribution of Dermal and Inhalation Exposure Components to End-Exhaled Breath Concentrations of Naphthalene, Kim, et al.

Real-Time air monitoring?


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Concluding.. Modeling Demonstrates Contribution of Dermal and Inhalation Exposure Components to End-Exhaled Breath Concentrations of Naphthalene, Kim, et al.

Thank you for your kind attention.

May I address your questions?

Special Thanks to these Impact Assessment contributors:

US Army Center for Health Promotion & Preventive Medicine, Noblis Inc., Booze-Allan Hamilton, Concurrent Technologies Corp.


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