Impact of the Severity of Seasonal Influenza-like Illnesses (ILI) and Heptavalent Pneumococcal Conju...
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Impact of the Severity of Seasonal Influenza-like Illnesses (ILI) and Heptavalent Pneumococcal Conjugate Vaccine (PCV7) on Invasive Pneumococcal Disease (IPD) in Children and Adults at a Health System in New York.

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Background

Impact of the Severity of Seasonal Influenza-like Illnesses (ILI) and Heptavalent Pneumococcal Conjugate Vaccine (PCV7) on Invasive Pneumococcal Disease (IPD) in Children and Adults at a Health System in New York

Lorry G. Rubin1, Shideh Shafinoori1, Christine C. Ginocchio1, Abby J. Greenberg2, Elaine A. Yeoman2 and Minawatee Cheddie2

(1) North Shore Long Island Jewish Health System

New Hyde Park, NY and

(2) Nassau County Department of Health

Mineola, NY


Background

BACKGROUND

  • Viral upper respiratory influenza-like illnesses (ILI) predispose to invasive pneumococcal disease (IPD)

  • Use of heptavalent pneumococcal vaccine (PCV7) should reduce incidence of IPD


Objective

OBJECTIVE

  • To determine if the observed decrease in IPD following the use of PCV7 vaccine is partially due to variations in the rate of Influenza-like illness


Methods

METHODS

  • Determine and compare rates of IPD and ILI

    • 2 years before routine PCV 7 use (7/98 - 6/00)

    • during routine PCV7 use (7/00 - 6/03)


Calculations

CALCULATIONS

  • Invasive Pneumococcal Disease (IPD) Rate

    • Cases/season IPD in 7 hospitals in a single health care system

  • Emergency Department (ED) Visits

    • Visits/season in the 7 hospital system

  • Influenza-like Illness (ILI) Incidence

    • Reports from all 13 hospitals in county where most of the system hospitals are

    • reports from all schools in same county


Analyses

ANALYSES

  • 634 IPD cases identified in the 7 hospitals in a health care system in the 5 year period 1998 - 2003

  • 67% IPD cases occurred during the influenza season (November - April)

  • Rates of IPD episodes (cases/105 ED visits) compared before vs during PCV7 years

  • ILI reports compared before vs during PCV7 years


Decrease in ipd 10 5 ed visits pcv7 years vs pre pcv7 years

DECREASE IN IPD/105 ED VISITS (PCV7 YEARS VS PRE-PCV7 YEARS)


Decrease in ili reports pcv7 years vs pre pcv7 years

DECREASE IN ILI REPORTS(PCV7 YEARS VS PRE-PCV7 YEARS)


Conclusion

CONCLUSION

  • Milder ILI seasons during the PCV7 period may have contributed to the reduction in IPD rates


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