1 / 59

PubChem and Related Open Cheminformatic Resources: A Revolution in the Connectivity Between Medicinal Chemistry and Biol

Outline. The way it wasThe revolutionPubChem aims and contentMaking the chemistry and biology joinsChemical systems biologyDrug Bank and Chem SpiderWider implications. The Context. Medicinal chemistry provides a bridge between biology and chemistry by identifying compounds that produce biolog

clara
Download Presentation

PubChem and Related Open Cheminformatic Resources: A Revolution in the Connectivity Between Medicinal Chemistry and Biol

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

    1. PubChem and Related Open Cheminformatic Resources: A Revolution in the Connectivity Between Medicinal Chemistry and Biology Course in Advanced Medicinal Chemistry (KEN760) Lecture Chalmers Technical University, Oct 2007 Chris Southan, ChrisDS Consulting, Gteborg http://www.cdsouthan.info/CDS_proff.htm

    2. Outline The way it was The revolution PubChem aims and content Making the chemistry and biology joins Chemical systems biology Drug Bank and Chem Spider Wider implications

    3. The Context Medicinal chemistry provides a bridge between biology and chemistry by identifying compounds that produce biological effects Historically, the goal has been to optimize therapeutic efficacy and avoid undesired biological effects i.e. develop new medicines However, it is increasingly recognised that bioactive cpds can be part of the perturbation toolbox for the investigation of all types of biological processes By advancing biological knowledge at both the molecular and systems level such investigations can lead to improved understanding of disease and new opportunities for classical medicinal chemistry

    4. Acceleration of Global Medicinal Chemistry Output This includes not only ~ 30K development cpds produced over the last 20 years but also post-genomic, post-HTS, post-libraries output acceleration Much of this is being published in med chem journals and estimates suggest global pharma/biotech patent output of at least 300K compound claims per year Because the targetome is small we are approaching the point where nearly all tractable targets, directly or by homology, will have available chemical modulation starting points

More Related