Perinatal Substance Exposure: Challenges. Priya Jegatheesan, MD Balaji Govindaswami, MBBS, MPH Division of Neonatology, Santa Clara Valley Medical Center, San Jose. August 12 th , 2014. Objective. Scope of the problem of substance abuse Biology of addiction in adult vs. newborns
Priya Jegatheesan, MD
Balaji Govindaswami, MBBS, MPH
Division of Neonatology,
Santa Clara Valley Medical Center, San Jose.
August 12th, 2014
Abuse – emotional, physical, sexual
Infections – HIV, Hep B, Hep C
Transmission IV, blood products, sexual transmission
Risk FactorsIV drug useRisky sexual related behaviorRisky drug related behaviorImmunocompromised
Physical signs of withdrawal from opiates is mediated by Neuro Epinephrine
Neurons in Locus
Ceruleusin Mid Brain.
LC – Neurons have Mu receptors , Alpha 2 Adrenergic receptors that decrease NE via adenylcyclase – cAMP - PKA