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Biological chemistry. Carl Henrik Gørbitz, Ute Krengel Department of Chemistry, UiO. Crystal engineering. Biomarker identification. Protein crystallography. Molecules. H 2. ethane. sucrose. Molecules. Molecules. Crystal. Crystal. ”Crystal engineering”, we make a supermolecule!.

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Carl Henrik Gørbitz, Ute Krengel Department of Chemistry, UiO

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Biological

chemistry

Carl Henrik Gørbitz, Ute Krengel

Department of Chemistry, UiO


Crystal engineering

Biomarker identification

Protein crystallography


Molecules

H2

ethane

sucrose


Molecules


Molecules


Crystal


Crystal

”Crystal engineering”, we make a supermolecule!


Building blocks

linker

node


Xe-atoms on Ni-surface (Don Eigler, 1989)

Problem 1

Molecules are very small, hard to

put together one by one


Problem 2

As they are so small, we must put together very many before we reach a macroscopic size

A 1 x 1 x 1 mm sugar crystal

contains 1,4 · 1018 molecules


Building blocks


Building blocks


Glue


Intermolecular forces

Must be:

  • strong

  • Directional

    Two main types used in CE:

  • Hydrogen bonds

  • Metal coordination


MOFs

  • “Metal-Organic Frameworks (MOFs) are crystalline compounds consisting of metal ions or clusters coordinated to often rigid organic molecules to form one-, two-, or three-dimensional structures that can be porous”(from Wikipedia)

MOF-5


Can we do this without metal ions?


Guanidinium derivatives

Fumaric acid complex


Guanidinium derivatives


DNA-based systems


DNA-based systems


DNA-based systems


Applications

Construction of

  • polar materials for non-linear optics

  • molecular magnets

  • porous materials for storage

  • molecular sieves

  • sensors

  • molecule traps

  • biological model systems

  • catalysts

  • and much more


Biomarker identification

Biomarker: A biological molecule found in blood, other body fluids, or tissues that is a sign of a normal or abnormal process, or of a condition or disease. A biomarker may be used to see how well the body responds to a treatment for a disease or condition. Also called molecular marker and signature molecule

Present in small amounts = hard to identify


Biomarker identification

Nano-HPLC-system


Group

Lianglin

Lise-Lotte

Carl Henrik

Malgorzata

Steven

Fassil

Ola


Protein crystallography


Structure/Function Studies of Medically Relevant Systems

Department of Chemistry

University of Oslo

Ute Krengel


Methods

  • X-ray crystallography

  • Complementary techniques (molecular biology, protein chemistry, ligand binding studies, cell biology, molecular docking, organic chemistry)


Targets

  • Glycobiological Targets

    • Mucins

    • Bacterial Toxins

    • Bacterial Adhesins

    • Anti-tumor Antibodies

    • Mushroom Lectins

  • Enzymes

    • Chorismate mutases

GlycoNor

ProtStruct


Masters Projects

  • Glycobiological Targets:

    • Bacterial Toxins – Structure and Function

      • Investigation of blood group dependence

      • Delivery mechanisms?

      • Drug design

    • Anti-tumor Antibodies for Immunotherapy

      • Recombinant production, crystallization and X-ray structure determination


Group

Ute

Øyvind

Dani

Hedda

Dipankar

Daniel

Julie


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