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Biological chemistry. Carl Henrik Gørbitz, Ute Krengel Department of Chemistry, UiO. Crystal engineering. Biomarker identification. Protein crystallography. Molecules. H 2. ethane. sucrose. Molecules. Molecules. Crystal. Crystal. ”Crystal engineering”, we make a supermolecule!.

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Carl henrik g rbitz ute krengel department of chemistry uio

Biological

chemistry

Carl Henrik Gørbitz, Ute Krengel

Department of Chemistry, UiO


Crystal engineering

Crystal engineering

Biomarker identification

Protein crystallography


Molecules
Molecules

H2

ethane

sucrose





Crystal1
Crystal

”Crystal engineering”, we make a supermolecule!


Building blocks
Building blocks

linker

node


Problem 1

Xe-atoms on Ni-surface (Don Eigler, 1989)

Problem 1

Molecules are very small, hard to

put together one by one


Problem 2
Problem 2

As they are so small, we must put together very many before we reach a macroscopic size

A 1 x 1 x 1 mm sugar crystal

contains 1,4 · 1018 molecules





Intermolecular forces
Intermolecular forces

Must be:

  • strong

  • Directional

    Two main types used in CE:

  • Hydrogen bonds

  • Metal coordination


MOFs

  • “Metal-Organic Frameworks (MOFs) are crystalline compounds consisting of metal ions or clusters coordinated to often rigid organic molecules to form one-, two-, or three-dimensional structures that can be porous”(from Wikipedia)

MOF-5



Guanidinium derivatives
Guanidinium derivatives

Fumaric acid complex






Applications
Applications

Construction of

  • polar materials for non-linear optics

  • molecular magnets

  • porous materials for storage

  • molecular sieves

  • sensors

  • molecule traps

  • biological model systems

  • catalysts

  • and much more


Biomarker identification
Biomarker identification

Biomarker: A biological molecule found in blood, other body fluids, or tissues that is a sign of a normal or abnormal process, or of a condition or disease. A biomarker may be used to see how well the body responds to a treatment for a disease or condition. Also called molecular marker and signature molecule

Present in small amounts = hard to identify


Biomarker identification1
Biomarker identification

Nano-HPLC-system


Group
Group

Lianglin

Lise-Lotte

Carl Henrik

Malgorzata

Steven

Fassil

Ola



Structure function studies of medically relevant systems

Structure/Function Studies of Medically Relevant Systems

Department of Chemistry

University of Oslo

Ute Krengel


Methods

  • X-ray crystallography

  • Complementary techniques (molecular biology, protein chemistry, ligand binding studies, cell biology, molecular docking, organic chemistry)


Targets

  • Glycobiological Targets

    • Mucins

    • Bacterial Toxins

    • Bacterial Adhesins

    • Anti-tumor Antibodies

    • Mushroom Lectins

  • Enzymes

    • Chorismate mutases

GlycoNor

ProtStruct


Masters Projects

  • Glycobiological Targets:

    • Bacterial Toxins – Structure and Function

      • Investigation of blood group dependence

      • Delivery mechanisms?

      • Drug design

    • Anti-tumor Antibodies for Immunotherapy

      • Recombinant production, crystallization and X-ray structure determination


Group

Ute

Øyvind

Dani

Hedda

Dipankar

Daniel

Julie


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