Carl henrik g rbitz ute krengel department of chemistry uio
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Biological chemistry. Carl Henrik Gørbitz, Ute Krengel Department of Chemistry, UiO. Crystal engineering. Biomarker identification. Protein crystallography. Molecules. H 2. ethane. sucrose. Molecules. Molecules. Crystal. Crystal. ”Crystal engineering”, we make a supermolecule!.

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Carl Henrik Gørbitz, Ute Krengel Department of Chemistry, UiO

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Carl henrik g rbitz ute krengel department of chemistry uio

Biological

chemistry

Carl Henrik Gørbitz, Ute Krengel

Department of Chemistry, UiO


Crystal engineering

Crystal engineering

Biomarker identification

Protein crystallography


Molecules

Molecules

H2

ethane

sucrose


Molecules1

Molecules


Molecules2

Molecules


Crystal

Crystal


Crystal1

Crystal

”Crystal engineering”, we make a supermolecule!


Building blocks

Building blocks

linker

node


Problem 1

Xe-atoms on Ni-surface (Don Eigler, 1989)

Problem 1

Molecules are very small, hard to

put together one by one


Problem 2

Problem 2

As they are so small, we must put together very many before we reach a macroscopic size

A 1 x 1 x 1 mm sugar crystal

contains 1,4 · 1018 molecules


Building blocks1

Building blocks


Building blocks2

Building blocks


Carl henrik g rbitz ute krengel department of chemistry uio

Glue


Intermolecular forces

Intermolecular forces

Must be:

  • strong

  • Directional

    Two main types used in CE:

  • Hydrogen bonds

  • Metal coordination


Carl henrik g rbitz ute krengel department of chemistry uio

MOFs

  • “Metal-Organic Frameworks (MOFs) are crystalline compounds consisting of metal ions or clusters coordinated to often rigid organic molecules to form one-, two-, or three-dimensional structures that can be porous”(from Wikipedia)

MOF-5


Can we do this without metal ions

Can we do this without metal ions?


Guanidinium derivatives

Guanidinium derivatives

Fumaric acid complex


Guanidinium derivatives1

Guanidinium derivatives


Dna based systems

DNA-based systems


Dna based systems1

DNA-based systems


Dna based systems2

DNA-based systems


Applications

Applications

Construction of

  • polar materials for non-linear optics

  • molecular magnets

  • porous materials for storage

  • molecular sieves

  • sensors

  • molecule traps

  • biological model systems

  • catalysts

  • and much more


Biomarker identification

Biomarker identification

Biomarker: A biological molecule found in blood, other body fluids, or tissues that is a sign of a normal or abnormal process, or of a condition or disease. A biomarker may be used to see how well the body responds to a treatment for a disease or condition. Also called molecular marker and signature molecule

Present in small amounts = hard to identify


Biomarker identification1

Biomarker identification

Nano-HPLC-system


Group

Group

Lianglin

Lise-Lotte

Carl Henrik

Malgorzata

Steven

Fassil

Ola


Carl henrik g rbitz ute krengel department of chemistry uio

Protein crystallography


Structure function studies of medically relevant systems

Structure/Function Studies of Medically Relevant Systems

Department of Chemistry

University of Oslo

Ute Krengel


Carl henrik g rbitz ute krengel department of chemistry uio

Methods

  • X-ray crystallography

  • Complementary techniques (molecular biology, protein chemistry, ligand binding studies, cell biology, molecular docking, organic chemistry)


Carl henrik g rbitz ute krengel department of chemistry uio

Targets

  • Glycobiological Targets

    • Mucins

    • Bacterial Toxins

    • Bacterial Adhesins

    • Anti-tumor Antibodies

    • Mushroom Lectins

  • Enzymes

    • Chorismate mutases

GlycoNor

ProtStruct


Carl henrik g rbitz ute krengel department of chemistry uio

Masters Projects

  • Glycobiological Targets:

    • Bacterial Toxins – Structure and Function

      • Investigation of blood group dependence

      • Delivery mechanisms?

      • Drug design

    • Anti-tumor Antibodies for Immunotherapy

      • Recombinant production, crystallization and X-ray structure determination


Carl henrik g rbitz ute krengel department of chemistry uio

Group

Ute

Øyvind

Dani

Hedda

Dipankar

Daniel

Julie


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