You say mitosis and i say meiosis
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You Say Mitosis and I Say Meiosis. or How Cells Reproduce. A. Introduction. The ability of organisms to reproduce their kind is one characteristic that distinguishes living things from nonliving matter.

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You say mitosis and i say meiosis

You Say Mitosis and I Say Meiosis..

or How Cells Reproduce


A introduction

A. Introduction

  • The ability of organisms to reproduce their kind is one characteristic that distinguishes living things from nonliving matter.

  • The continuity of life from one cell to another is based on the reproduction of cells through cell division.

  • This process occurs as part of the life of a cell from its origin in the division of a parent cell until its own division into two.


B cell division functions in reproduction growth and repair

B. Cell division functions in reproduction, growth, and repair

  • The division of a unicellular organism reproduces an entire organism, increasing the population.

  • Cell division on a larger scale can produce offspring for some multicellular organisms.


You say mitosis and i say meiosis

  • Cell division is also central to the growth and development of a multicellular organism that begins as a fertilized egg or zygote.

  • Multicellular organisms also use cell division to repair and renew cells that die from normal wear and tear or accidents.


You say mitosis and i say meiosis

  • Cell division requires the distribution of identical genetic material - DNA - to two daughter cells.

    • What is remarkable is the continuity with which DNA is passed along, without much change from one generation to the next.

  • A dividing cell duplicates its DNA, distributes the two copies to opposite ends of the cell, and then splits into two daughter cells.


C cell division distributes identical sets of chromosomes to daughter cells

C. Cell division distributes identical sets of chromosomes to daughter cells

  • A cells genetic information, packaged as DNA, is called its genome.

    • In prokaryotes, the genome is often a single long DNA molecule.

    • In eukaryotes, the genome consists of several DNA molecules.

  • A human cell must duplicate about 3 meters of DNA and separate the two copies such that each daughter cell ends up with a complete genome.


You say mitosis and i say meiosis

  • DNA molecules are packaged into chromosomes.

    • Every eukaryotic species has a characteristic number of chromosomes in the nucleus.

      • Human somatic cells (body cells) have 46 chromosomes.

      • Human gametes (sperm or eggs) have 23 chromosomes, half the number in a somatic cell.


You say mitosis and i say meiosis

  • Each eukaryotic chromosome consists of a long, linear DNA molecule.

  • Each chromosome has hundreds or thousands of genes, the units that specify an organisms inherited traits.

  • Associated with DNA are histone proteins that maintain its structure and help control gene activity.

  • This DNA-protein complex, chromatin, is organized into a long thin fiber.

  • After the DNA duplication, chromatin condenses, coiling and folding to make a smaller package.

animation


You say mitosis and i say meiosis

  • Each duplicated chromosome consists of two sister chromatids which contain identical copies of the chromosomes DNA.

  • The area where the

    chromatids connect (like a

    thumbtack) is the centromere.

  • Later, the sister chromatids are pulled apart and repackaged into two new nuclei at opposite ends of the parent cell.


You say mitosis and i say meiosis

  • The process of the formation of the two daughter nuclei, mitosis, is usually followed by division of the cytoplasm which is called cytokinesis.

  • Mitosis takes one cell and produces two cells that are the genetic equivalent of the parent.


You say mitosis and i say meiosis

  • Each of us inherited 23 chromosomes from each parent: one set in an egg and one set in sperm.

  • The fertilized egg or zygote underwent trillions of cycles of mitosis and cytokinesis to produce a fully developed multicellular human.

  • These processes continue every day to replace dead and damaged cell.

  • Essentially, these processes produce clones - cells with the same genetic information.


D a day in the life of a cell

D: A Day in the Life of a Cell

  • The mitotic (M) phase of the cell cycle alternates with the much longer interphase.

    • The M phase includes mitosis and cytokinesis (about one hour in length for eukaryotes)

    • Interphase accounts for 90% of the cell cycle or 23 hours out of the day.

    • During Interphase the cell is conducting all life activities and getting ready for the next round of mitosis to occur (in most cells)


You say mitosis and i say meiosis

animation


You say mitosis and i say meiosis

  • During interphase the cell grows by producing proteins and cytoplasmic organelles, copies its chromosomes, and prepares for cell division.

  • Interphase has three subphases:

    • the G1 phase (first gap) centered on growth,

    • the S phase (synthesis) when the chromosomes are copied,

    • the G2 phase (second gap) where the cell completes preparations for cell division,

  • The cell divides (M).

  • The daughter cells may then repeat the cycle.


You say mitosis and i say meiosis

  • The distinct events of the cell cycle are directed by a distinct cell cycle control system.

    • Some molecules trigger and coordinate key events in the cell cycle.

    • The control cycle has a built-in clock, but it is also regulated by external adjustments and internal controls.


You say mitosis and i say meiosis

  • A checkpoint in the cell cycle is a critical control point where stop and go signals regulate the cycle.

  • Three major checkpoints are found in the G1, G2, and M phases.


You say mitosis and i say meiosis

Great animation

  • For many cells, the G1 checkpoint, the restriction point in mammalian cells, is the most important.

    • If the cells receives a go-ahead signal, it usually completes the cell cycle and divides.

    • If it does not receive a go-ahead signal, the cell exits the cycle and switches to a nondividing state, the G0 phase.

      • Most human cells are in this phase.

      • Liver cells can be called back to the cell cycle by external cues (growth factors), but highly specialized nerve and muscle cells never divide.

Click here


Regulation of the cell cycle

Regulation of the cell cycle

  • Protein signals inhibit or activate the cell cycle.

  • Molecules called cyclins together with CDKs (cyclin dependent kinases) form MPFs (mitotic promoting factors)

  • These proteins are important in regulating the cell cycle and cause cell proliferation.

  • Inhibitors of CDKs are used to treat cancer


You say mitosis and i say meiosis

  • E. Mitosis is a continuum of changes.

    • For description, mitosis is usually broken into five subphases:

      • prophase,

      • prometaphase,

      • metaphase,

      • anaphase, and

      • telophase.


You say mitosis and i say meiosis

  • By late interphase (after the S phase), the chromosomes have been duplicated but are loosely packed.

  • The centrosomes with centrioles in animal cells have been duplicated

    and begin to organize

    microtubules into an

    aster (star).


You say mitosis and i say meiosis

  • In prophase, the chromosomes are tightly coiled and become visible, with sister chromatids joined together.

  • The nucleoli and

    nuclear membrane

    begin to disappear.

  • The mitotic spindle begins to form and appears to push the centrosomes away from each other toward opposite ends (poles) of the cell.


You say mitosis and i say meiosis

  • During prometaphase, the nuclear envelope fragments and microtubules from the spindle interact with the chromosomes.

  • Microtubules from one pole attach to one of two kinetochores, special regions of the centromere,

kinetochores


You say mitosis and i say meiosis

  • In metaphase the sister chromatids line up at the metaphase plate, an imaginary plane equidistant between the poles, defining metaphase.


You say mitosis and i say meiosis

  • At anaphase, the centromeres divide, separating the sister chromatids.

  • Each is now pulled toward the pole to which it is attached by spindle fibers.

  • By the end, the two poles have equivalent collections of chromosomes.


You say mitosis and i say meiosis

  • At telophase, the cell continues to elongate as free spindle fibers from each centrosome push off each other.

  • Two nuclei begin for form, as the nuclear envelope begins to

    reappear.

  • Cytokinesis, division of the cytoplasm, ends.


Animation

Animation

Animation #2


F cytokinesis divides the cytoplasm a closer look

F.Cytokinesis divides the cytoplasm: a closer look

  • Cytokinesis, division of the cytoplasm, typically follows mitosis.

  • In animals, the first sign of cytokinesis (cleavage) is the appearance of a cleavage furrow in the cell surface near the old metaphase plate.


You say mitosis and i say meiosis

  • On the cytoplasmic side of the cleavage furrow a contractile ring of actin microfilaments and the motor protein myosin form.

  • Contraction of the ring pinches the cell in two.


You say mitosis and i say meiosis

  • Cytokinesis in plants, which have cell walls, involves a completely different mechanism.

  • During telophase, vesicles from the Golgi fuse at the metaphase plate, forming a cell plate.

    • The plate enlarges until its membranes fuse with the plasma membrane at the perimeter, with the contents of the vesicles forming new wall material in between.


Animation of cell plate formation

Animation of cell plate formation


G mitosis in eukaryotes may have evolved from binary fission in bacteria

G. Mitosis in eukaryotes may have evolved from binary fission in bacteria

  • Prokaryotes reproduce by binary fission, not mitosis.

  • Most bacterial genes are located on a single bacterial chromosome which consists of a circular DNA molecule and associated proteins.

  • While bacteria do not have as many genes or DNA molecules as long as those in eukaryotes, their circular chromosome is still highly folded and coiled in the cell.


You say mitosis and i say meiosis

  • In binary fission, chromosome replication begins at one point in the circular chromosome, the origin of replication site.

  • These copied regions begin to move to opposite ends of the cell.


You say mitosis and i say meiosis

  • The mechanism behind the movement of the bacterial chromosome is still an open question.

  • As the bacterial chromosome is replicating and the copied regions are moving to opposite ends of the cell, the bacterium continues to grow until it reaches twice its original size.


You say mitosis and i say meiosis

  • Cell division involves inward growth of the plasma membrane, dividing the parent cell into two daughter cells, each with a complete genome.


You say mitosis and i say meiosis

  • It is quite a jump from binary fission to mitosis.

  • Possible intermediate evolutionary steps are seen in the division of two types of unicellular algae.

    • In dinoflagellates, replicated chromosomes are attached to the nuclear envelope.

    • In diatoms, the spindle develops within the nucleus.


H how is cancer related to mitosis

H. How is Cancer Related to Mitosis?

  • Cancer is uncontrolled mitosis!

  • Cancer cells divide excessively and invade other tissues because they are free of the bodys control mechanisms.

    • Cancer cells do not stop dividing when growth factors are depleted either because they manufacture their own, have an abnormality in the signaling pathway, or have a problem in the cell cycle control system.

  • If and when cancer cells stop dividing, they do so at random points, not at the normal checkpoints in the cell cycle.


You say mitosis and i say meiosis

  • Cancer cell may divide indefinitely if they have a continual supply of nutrients.

    • In contrast, nearly all mammalian cells divide 20 to 50 times under culture conditions before they stop, age, and die.

    • Cancer cells may be immortal.

      • Cells from a tumor removed from a woman (Henrietta Lacks) in 1951 are still reproducing in culture.


You say mitosis and i say meiosis

In 1951, a scientist at Johns Hopkins Hospital in Baltimore, Maryland, created the first immortal human cell line with a tissue sample taken from a young black woman with cervical cancer. Those cells, called HeLa cells, quickly became invaluable to medical research.


You say mitosis and i say meiosis

They were essential to developing the polio vaccine.

They went up in the first space missions to see what would happen to cells in zero gravity.

Many scientific landmarks since then have used her cells, including cloning, gene mapping and in vitro fertilization.


Hela karyotypes

HeLa karyotypes:


You say mitosis and i say meiosis

  • The abnormal behavior of cancer cells begins when a single cell in a tissue undergoes a transformation that converts it from a normal cell to a cancer cell.

    • Normally, the immune system recognizes and destroys transformed cells.

    • However, cells that evade destruction proliferate to form a tumor, a mass of abnormal cells.

  • If the abnormal cells remain at the originating site, the lump is called a benign tumor.

    • Most do not cause serious problems and can be removed by surgery.


You say mitosis and i say meiosis

An overview with several animations showing how cancer develops. Click here


You say mitosis and i say meiosis

  • In a malignant tumor, the cells leave the original site and impairs the functions of one or more organs.

animation


You say mitosis and i say meiosis

animation


You say mitosis and i say meiosis

  • Treatments for metastasizing cancers include high-energy radiation and chemotherapy with toxic drugs.

    • These treatments target actively dividing cells.

  • Researchers are beginning to understand how a normal cell is transformed into a cancer cell.

    • The causes are diverse.

    • However, cellular transformation always involves the alteration of genes that influence the cell cycle control system.


How can natural killer cells in our immune system help to fight cancer

How can Natural Killer Cells in Our Immune System help to fight cancer?

  • See this youtube video


Cancer and gene regulation

Cancer and gene regulation

http://learn.genetics.utah.edu/content/epigenetics/control/


Where does cancer uncontrolled mitosis come from

Where does cancer (uncontrolled mitosis) come from?

  • Faulty signaling pathways

  • Mutations in human genome (p53 site)


Click here to learn about the p53 site of the genome and cancer

Click here to learn about the p53 site of the genome and cancer


I a close look at mitosis as a form of reproduction

I. A close look at mitosis as a form of reproduction.

  • In asexual reproduction, a single individual passes along copies of all its genes to its offspring.

    • Single-celled eukaryotes reproduce asexually by mitotic cell division to produce two identical daughter cells.

    • Even some multicellular eukaryotes, like hydra, can reproduce by budding cells produced by mitosis.


In animals there are many examples of asexual reproduction

In animals, there are many examples of asexual reproduction

  • Invertebrates:

    • Fission: asexual reproduction in which a parent separates into two or more approximately equal sized individuals.

    • Budding: asexual reproduction in which new individuals split off from existing ones.

Video of hydra budding


You say mitosis and i say meiosis

Lizard loses tail video

  • Fragmentation: the breaking of the body into several pieces, some or all of which develop into complete adults.

    • Requires regeneration of lost body parts.

    • Example a lizard trying to escape a predator biting its tail can lose this part of its body and regrow a new tail.

    • Stories have been told of oyster fisherman who try to rid their oyster beds of predatory starfish by slicing them up and throwing them back to sea. Why would this technique backfire?


You say mitosis and i say meiosis

  • Parthenogenesis (virgin birth) is the process by which an unfertilized egg develops into (often) haploid adult or the individual produces a diploid fertilized egg.

    • Parthenogenesis plays a role in the social organization of species of bees, wasps, and ants.

      • Male honeybees are haploid and female honeybees are diploid.

    • Several genera of fishes, amphibians, and lizards produce by a form of parthenogenesis that produces diploid zygotes.


What are the benefits of asexual reproduction

What are the benefits of asexual reproduction


J many plants clone themselves by asexual reproduction

J. Many plants clone themselves by asexual reproduction

  • Many plants clone themselves by asexual reproduction, also called vegetative propagation.

    • This occurs when a part separates from the overall plant and eventually develops into a whole plant.

    • This clone would be identical to the parent.


You say mitosis and i say meiosis

  • Asexual reproduction is an extension of the capacity of plants for growth.

    • Meristematic tissues with dividing undifferentiated cells can sustain or renew growth indefinitely- usually found at the tips of a stem or the bottom of a root

    • Parenchyma cells throughout the plant can divide and differentiate into various types of specialized cells.


You say mitosis and i say meiosis

  • In fragmentation, a parent plant separates into parts that reform whole plants.

  • A variation of this occurs in some dicots, in which the root system of a single parent gives rise to many adventitious shoots that become separate root systems, forming a clone. (aka-runners)

    • A ring of creosote bushes in the Mojave Desert of California is believed to be at least 12,000 years old.


You say mitosis and i say meiosis

  • One advantage of asexual reproduction is that a plant well suited to a particular environment can clone many copies of itself rapidly.

  • Moreover, the offspring of vegetative reproduction are not as fragile as seedlings produced by sexual reproduction.


K vegetative propagation of plants is common in agriculture

K. Vegetative propagation of plants is common in agriculture

  • Various methods have been developed for the asexual propagation of crop plants, orchards, and ornamental plants.

    • These can be reproduced asexually from plant fragments called cuttings.

    • These are typically pieces of shoots or stems.


You say mitosis and i say meiosis

  • Some plants, including African violets, can be propagated from single leaves (known as cuttings)

  • In others, specialized storage stems can be cut into several pieces and develop into clones.

    • For example, a piece of a potato including an eye can regenerate a whole plant.


You say mitosis and i say meiosis

  • A twig or bud from one plant can be grafted onto a plant of a closely related species or a different variety of the same species.

    • This makes it possible to combine the best properties of different species or varieties into a single plant.

    • The plant that provides the root system is called the stock and the twig grafted onto the stock is the scion.

    • For example, a cocktail fruit tree can be made from grafting pears, apples, apricots and oranges on the same tree!


You say mitosis and i say meiosis

Advantages of asexual reproduction:

Can reproduce without needing to find a mate

Can have numerous offspring in a short period of time

In stable environments, allows for the perpetuation of successful genotypes.


L meiosis is another type of cell reproduction used in sexually reproducing organisms

L. Meiosis is another type of cell reproduction used in sexually reproducing organisms

  • Meiosis is a type of cell division whereby gametes sex cells are made.

  • Meiosis occurs in the gonads- sex organs of sexually reproducing organisms

    In animals, the gonads are the ovaries and testes.

    In flowering plants (angiosperms), the female gonad is the ovary and the male gonad is the anther.


M why is meiosis necessary for organisms that reproduce sexually

M. Why is Meiosis Necessary for Organisms that Reproduce Sexually?

  • Meiosis produces cells with half of the chromosome number.

  • When gametes unite during fertilization, the chromosome number must remain constant through generations.

  • For example, if fruit flies have a chromosome number of 8, what would happen if their gametes had 8 chromosomes as well and fertilization occurred?


You say mitosis and i say meiosis

N. Meiosis results in variation in the species.

  • Sexual reproduction results in greater variation among offspring than does asexual reproduction which is key to evolution.

  • Two parents give rise to offspring that have unique combinations of genes inherited from the parents.

  • Offspring of sexualreproduction vary genetically from their siblings and from both parents.


O background information and vocabulary needed for our understanding of meiosis

O. Background information and vocabulary needed for our understanding of meiosis

  • In humans, each somatic cell (all cells other than sperm or ovum) has 46 chromosomes.

  • A karyotype display of the 46 chromosomes shows 23 pairs of chromosomes, each pair with the same length, centromere position, and staining pattern.

  • These homologous chromosome pairs carry genes that control the same inherited characters.


You say mitosis and i say meiosis

  • Karyotypes, can detect problems in chromosomes numbers of a fetus- like Downs Syndrome.


You say mitosis and i say meiosis

  • An exception to the rule of homologous chromosomes is found in the sex chromosomes, the X and the Y.

  • The pattern of inheritance of these chromosomes determine an individuals sex.

    • Human females have a homologous pair of X chromosomes (XX).

    • Human males have an X and a Y chromosome (XY).

  • Because only small parts of these have the same genes, most of their genes have no counterpart on the other chromosome.

  • The other 22 pairs are called autosomes.


You say mitosis and i say meiosis

  • The occurrence of homologous pairs of chromosomes is a consequence of sexual reproduction.

  • We inherit one chromosome of each homologous pair from each parent.

    • The 46 chromosomes in a somatic cell can be viewed as two sets of 23, a maternal set and a paternal set.

  • Sperm cells or ova (gametes) have only one set of chromosomes - 22 autosomes and an X or a Y.

  • A cell with a single chromosome set is haploid -symbol is nwhere n is the number of homologous pairs

    • For humans, the haploid number of chromosomes is 23 (n = 23).


You say mitosis and i say meiosis

  • By means of sexual intercourse, a haploid sperm reaches and fuses with a haploid ovum.

  • These cells fuse resulting in fertilization.

  • The fertilized egg (zygote) now has two haploid sets of chromosomes bearing genes from the maternal and paternal family lines.

  • The zygote and all cells with two sets of chromosomes are diploid cells symbolized as 2n (twice the # of homologous pairs)

    • For humans, the diploid number of chromosomes is 46 (2n = 46).


You say mitosis and i say meiosis

  • As an organism develops from a zygote to a sexually mature adult, the zygotes genes are passes on to all somatic cells by mitosis.

  • Gametes, which develop in the gonads, are not produced by mitosis.

    • If gametes were produced by mitosis, the fusion of gametes would produce offspring with four sets of chromosomes after one generation, eight after a second and so on.

  • Instead, gametes undergo the process of meiosis in which the chromosome number is halved.

    • Human sperm or ova have a haploid set of 23 different chromosomes, one from each homologous pair.


You say mitosis and i say meiosis

  • Fertilization restores the diploid condition by combining two haploid sets of chromosomes.

  • Fertilization and

    meiosis alternate in sexual

    life cycles.


You say mitosis and i say meiosis

  • The timing of meiosis and fertilization does vary among species.

  • The life cycle of humans and other animals is typical of one major type.

    • Gametes, produced by meiosis, are the only haploid cells.

    • Gametes undergo no divisions themselves, but fuse to form a diploid zygote that divides by mitosis to produce a multicellular organism.


You say mitosis and i say meiosis

  • Most fungi and some protists have a second type of life cycle.

    • The zygote is the only diploid phase.

    • After fusion of two gametes to form a zygote, the zygote undergoes meiosis to produce haploid cells.

    • These haploid cells undergo mitosis to develop into a haploid multicellular adult organism.

    • Some haploid cells develop into gametes by mitosis.


You say mitosis and i say meiosis

Look at the following life cycle of a plant and of some algae. How is it different from the life cycle of a human? How is it different from the life cycle of a fungus?

Difference from human:

Difference from fungus:

Multicellular haploid organism

Multicellular diploid organism


You say mitosis and i say meiosis

  • This life cycle includes both haploid (gametophyte) and diploid (sporophyte) multicellular stages.

  • Meiosis by the sporophyte produces haploid spores that develop by mitosis into the gametophyte.

  • Gametes produced via mitosis by the gametophyte fuse to form the zygote which produces the sporophyte by mitosis.

    • Plants and some algae have a third type of life cycle, alternation of generation.


    You say mitosis and i say meiosis

    Label the diagram with the following words: gametophyte, sporophyte, spores, zygote, mitosis, meiosis, fertilization


    You say mitosis and i say meiosis

    Spores (n)

    Gametophyte

    (n)

    Sporophyte

    (2n)

    Zygote (2n)


    P meiosis reduces chromosome number from diploid to haploid a closer look

    P. Meiosis reduces chromosome number from diploid to haploid: a closer look

    • Many steps of meiosis resemble steps in mitosis.

    • Both are preceded by the replication of chromosomes.

    • However, in meiosis, there are two consecutive cell divisions, meiosis I and meiosis II, which results in four daughter cells.

    • Each final daughter cell has only half as many chromosomes as the parent cell.


    You say mitosis and i say meiosis

    • Meiosis reduces chromosome number by copying the chromosomes once, but dividing twice.

    • The first division, meiosis I, separates homologous chromosomes.

    • The second, meiosis II, separates sister chromatids.


    You say mitosis and i say meiosis

    • Division in meiosis I occurs in four phases: prophase, metaphase, anaphase, and telophase.

    • During the preceding interphase the chromosomes are replicated to

      form sister chromatids.

      • These are genetically identical and joined at the centromere.

    • Also, the single centrosome is replicated.


    You say mitosis and i say meiosis

    • In prophase I, crossing over can occur!

    • The chromosomes condense and homologous chromosomes pair up to form tetrads.

      • In a process called synapsis, special proteins attach homologous chromosomes

        tightly together.

      • At several sites the chromatids of homologous chromosomes are crossed (chiasmata) and segments of the chromosomes are traded.

      • A spindle forms from each centrosome and spindle fibers attached to kinetochores on the chromosomes begin to move the tetrads around.


    You say mitosis and i say meiosis

    • At metaphase I, the tetrads are all arranged at the metaphase plate.

      • Microtubules from one pole are attached to the kinetochore of one chromosome of each tetrad, while those from the other pole are attached to the other.

    • In anaphase I, the homologous chromosomes separate and are pulled toward opposite poles.


    You say mitosis and i say meiosis

    • In telophase I, movement of homologous chromosomes continues until there is a haploid set at each pole.

      • Each chromosome consists of linked sister chromatids.

    • Cytokinesis by the same mechanisms as mitosis usually occurs simultaneously.

    • Interkinesis occurs-a brief

      intermission - but there is no further replication of chromosomes.


    You say mitosis and i say meiosis

    • Meiosis II is very similar to mitosis.

      • During prophase II a spindle apparatus forms, attaches to kinetochores of each sister chromatids, and moves them around.

        • Spindle fibers from one pole attach to the kinetochore of one sister chromatid and those of the other pole to the other sister chromatid.


    You say mitosis and i say meiosis

    • At metaphase II, the sister chromatids are arranged at the metaphase plate.

    • At anaphase II, the centomeres of sister chromatids separate and the now separate sisters travel toward opposite poles.


    You say mitosis and i say meiosis

    • In telophase II, separated sister chromosomes arrive at opposite poles.

      • Nuclei form around the chromosomes

    • Cytokinesis separates the cytoplasm.

    • At the end of meiosis, there are four haploid daughter cells.

    Click on animation

    Click on animation


    You say mitosis and i say meiosis

    • Q. Mitosis and meiosis have several key differences.

      • The chromosome number is reduced by half in meiosis, but not in mitosis.

      • Mitosis produces daughter cells that are genetically identical to the parent and to each other.

      • Meiosis produces cells that differ from the parent and each other.


    You say mitosis and i say meiosis

    • Three events, unique to meiosis, occur during the first division cycle.

      1. During prophase I, homologous chromosomes pair up in a process called synapsis when crossing over occurs.

      • A protein zipper, the synaptonemal complex, holds homologous chromosomes together tightly.

      • Later in prophase I, the joined homologous chromosomes are visible as a tetrad.

      • At X-shaped regions called chiasmata, sections of nonsister chromatids are exchanged.

      • CROSSING OVER LEADS TO GENETIC VARIATION!!!


    You say mitosis and i say meiosis

    2. At metaphase I homologous pairs of chromosomes, not individual chromosomes are aligned along the metaphase plate.

    • In humans, you would see 23 tetrads.

      3. At anaphase I, it is homologous chromosomes, not sister chromatids, that separate and are carried to opposite poles of the cell.

  • Sister chromatids remain attached at the centromere until anaphase II.

  • The processes during the second meiotic division are virtually identical to those of mitosis.


  • You say mitosis and i say meiosis

    • Mitosis produces two identical daughter cells, but meiosis produces 4 very different cells.


    You say mitosis and i say meiosis

    Found on a Biology t-shirt


    You say mitosis and i say meiosis

    Animation showing mitosis vs. meiosis


    R sexual life cycles produce genetic variation among offspring

    R. Sexual life cycles produce genetic variation among offspring

    • The behavior of chromosomes during meiosis and fertilization is responsible for most of the variation that arises each generation during sexual reproduction.

    • Three mechanisms contribute to genetic variation:

      • independent assortment

      • crossing over

      • random fertilization


    You say mitosis and i say meiosis

    • Independent assortment of chromosomes contributes to genetic variability due to the random orientation of tetrads at the metaphase plate.

      • There is a fifty-fifty chance that a particular daughter cell of meiosis I will get the maternal chromosome of a certain homologous pair and a fifty-fifty chance that it will receive the paternal chromosome.


    You say mitosis and i say meiosis

    • Each homologous pair of chromosomes is positioned independently of the other pairs at metaphase I.

    • Therefore, the first meiotic division results in independent assortment of maternal and paternal chromosomes into daughter cells.

    • The number of combinations possible when chromosomes assort independently into gametes is 2n, where n is the haploid number of the organism.

      • If n = 3, there are eight possible combinations.

      • For humans with n = 23, there are 223 or about 8 million possible combinations of chromosomes.

    Click on animation


    You say mitosis and i say meiosis

    • Independent assortment alone would find each individual chromosome in a gamete that would be exclusively maternal or paternal in origin.

    • However, crossing over produces recombinant chromosomes which combine genes inherited from each parent.


    You say mitosis and i say meiosis

    • Crossing over begins very early in prophase I as homologous chromosomes pair up gene by gene.

    • In crossing over, homologous portions of two nonsister chromatids trade places.

      • For humans, this occurs two to three times per chromosome pair.

    • One sister chromatid may undergo different patterns of crossing over than its match.

    • Independent assortment of these nonidentical sister chromatids during meiosis II increases still more the number of genetic types of gametes that can result from meiosis.


    You say mitosis and i say meiosis

    • The random nature of fertilization adds to the genetic variation arising from meiosis.

    • Any sperm can fuse with any egg.

      • A zygote produced by mating of a woman and man has a unique genetic identity.

      • An ovum is one of approximately 8 million possible chromosome combinations (actually 223).

      • The successful sperm represents one of 8 million different possibilities (actually 223).

      • The resulting zygote is composed of 1 in 70 trillion (223 x 223) possible combinations of chromosomes.

      • Crossing over adds even more variation to this.


    You say mitosis and i say meiosis

    • The three sources of genetic variability in a sexually reproducing organism are:

      • Independent assortment of homologous chromosomes during meiosis I and of nonidentical sister chromatids during meiosis II.

      • Crossing over between homologous chromosomes during prophase I.

      • Random fertilization of an ovum by a sperm.

    • All three mechanisms reshuffle the various genes carried by individual members of a population.

    • Mutations, still to be discussed, are what ultimately create a populations diversity of genes.


    S evolutionary adaptation depends on a population s genetic variation

    S. Evolutionary adaptation depends on a populations genetic variation

    • Darwin recognized the importance of genetic variation in evolution via natural selection.

    • A population evolves through the differential reproductive success of its variant members.

    • Those individuals best suited to the local environment leave the most offspring, transmitting their genes in the process.

    • This natural selection results in adaptation, the accumulation of favorable genetic variations.


    You say mitosis and i say meiosis

    • As the environment changes or a population moves to a new environment, new genetic combinations that work best in the new conditions will produce more offspring and these genes will increase.

      • The formerly favored genes will decrease.

    • Sex and mutations are two sources of the continual generation of new genetic variability.

    • Gregor Mendel, a contemporary of Darwin, published a theory of inheritance that helps explain genetic variation.

      • However, this work was largely unknown for over 40 years until 1900.


    T meiosis in males vs females

    T. Meiosis in males vs. females

    • Meiosis in males is called spermatogenesis : the birth of sperm

    • Meiosis in females is called

      oogenesis : the birth of an egg or ovum

      The timing of meiosis, and the size and number of gametes formed differ in males and females.


    Spermatogenesis and oogenesis both involve meiosis but differ in significant ways

    Spermatogenesis and oogenesis both involve meiosis but differ in significant ways

    • Spermatogenesis is the production of mature sperm cells from spermatogonia.

      • A continuous and prolific process in the adult male.

      • Each ejaculation contains 100 650 million sperm.

      • Occurs in seminiferous tubules.

      • As spermatogenesis progresses the developing sperm cells move from the seminiferous tubule to the epididymis where they can be temporarily stored.


    You say mitosis and i say meiosis

    • Sperm structure:

      • Haploid nucleus.

      • Tipped with an acrosome.

        • Contains enzymes that help the sperm penetrate to the egg.

        • A large numberof mitochondriaprovide ATP topower theflagellum.


    You say mitosis and i say meiosis

    • Oogenesis is the production of ova from oogonia.

      • Differs from spermatogenesis in three major ways:

        • At birth an ovary contains all of the primary oocytes it will ever have.

        • Unequal cytokinesis during meiosis results in the formation of a single large secondary oocyte and three small polar bodies.

          • The polar bodies degenerate.

        • Oogenesis has long resting periods.


    You say mitosis and i say meiosis

    animation


    Animation on nondisjunction in meiosis i

    Animation on nondisjunction in meiosis I

    Animation on nondisjunction in meiosis II


    Click here to see a youtube video that summarizes our unit

    Click here to see a youtube video that summarizes our unit!


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