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The Future of Translational Research (Pathways to Cures)

Learn how translational research is transforming scientific discoveries into clinical applications to reduce cancer incidence, morbidity, and mortality. Discover the challenges and potential solutions in this groundbreaking field.

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The Future of Translational Research (Pathways to Cures)

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  1. The Future of Translational Research(Pathways to Cures) Dr. Linda Malkas Deputy Director Research City of Hope Comprehensive Cancer Center

  2. Translational Research Translational research transforms scientific discoveries arising from laboratory, clinical, or population studies into clinical applications to reduce cancer incidence, morbidity, and mortality

  3. NIH Roadmap • Perceived loss of talent in translational medicine and clinical sciences • Difficulty finding scientist collaborators who can translate and clinically apply from basic science • Researchers interested have difficulty finding facilities to apply their interests

  4. Launched in 2006 • CTSA program currently supports ~60 academic medical institutions in the U.S. • NCATS oversight of CTSA occurred in 2011 and changed program

  5. Inland California Translational Consortium (ICTC) education, innovationand realization

  6. ICTC catchment area and locations of partner institutions

  7. Review Comments • The ICTC is a new CTSA program with unique potential to transform clinical and translational research at the four partnering institutions, with a high likelihood of a long-term, sustained impact on new innovations and introduction of new therapeutic interventions. This consortium represents an unparalleled combination of institutional commitment, diverse and comprehensive resources, and experience with development, manufacturing, and in-human testing of a wide variety of therapies. This infrastructure is coupled with a highly qualified, accomplished group of investigators, with well-established training programs and bioinformatics support.

  8. Review Comments • The ICTC has extensive experience in clinical and translational research with novel therapies and first in human studies. • They have seven-year history of Clinical Investigation Training Program, which has trained over 300 scholars. • Focus areas for research include discovery science, developmental therapeutics, biomedical engineering, economics, physical sciences, aging and lifespan, and nutrition and metabolism. • They have funded 22 IGNITE awards to teams of investigators from COH and Caltech, which generated 37 jointly owned patent applications. • The REALIZATION Team addresses bottlenecks by assisting intellectual property protection, project management, regulatory pathway navigator, manufacture of biological and small molecule materials, and Investigational New Drug (IND) submission. These will make available to other CTSAs.

  9. Review Comments • The ICTC has approaches targeted at young and old individuals. • There is a plan to share resources and infrastructure with other CTSA hubs. • Strong translational activities exist at teach partner, including the Caltech’s Division of Biology and Biological Engineering with micro- and nano-scale technologies, the Accreditation Council for Graduate Medical Education (ACGME)-recognized Notable Practice in Radiation Oncology at City of Hope, UCR’s Longitudinal Ambulatory Care Experience, and the Applied Entrepreneurship course at KGI. • They also created Community Health Navigator to help integrate healthcare with research.

  10. Inland California Translational Consortium (ICTC) education, innovationand realization

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