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بسم الله الرحمن الرحيم

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بسم الله الرحمن الرحيم. Oxidative Decarboxylation and Krebs Cycle. By. Amr S. Moustafa, M.D.; Ph.D. Clinical Biochemistry Unit, Pathology Dept. College of Medicine, King Saud University. ALT. Alanine. PLP. αKG. Glutamate. Fates of Pyruvate. Oxidative Decarboxylation of Pyruvate.

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oxidative decarboxylation and krebs cycle
Oxidative Decarboxylation and Krebs Cycle

By

Amr S. Moustafa, M.D.; Ph.D.

Clinical Biochemistry Unit, Pathology Dept.

College of Medicine, King Saud University

fates of pyruvate

ALT

Alanine

PLP

αKG

Glutamate

Fates of Pyruvate
pdh complex covalent regulation
PDH Complex: Covalent Regulation

Insulin

+

PDH

Insulin

Glucagon

-

PDH

P

+

Pi

H2O

Protein Phosphatase

Pyruvate dehydrogenase

complex (active)

Pyruvate dehydrogenase

complex (inactive)

Protein Kinase

ATP

ADP

+

Glucagon

tricarboxylic acid cycle krebs cycle
Tricarboxylic Acid Cycle: Krebs Cycle
  • Final common pathway for oxidation
  • Exclusively in mitochondria
  • Major source for ATP
  • Mainly catabolic with some anabolic features
  • Synthetic reactions (anabolic features):
  • Glucose from amino acids
  • Nonessential amino acids
  • Fatty acids
  • Heme
krebs cycle reactions 2
Krebs Cycle Reactions (2)

Succinate Thiokinase

Substrate-Level

Phosphorylation

phospho glycerate kinase

Glycolysis

(Cytosol)

Phospho-glycerate Kinase

2

2

Substrate-

Level

Phosphorylation

2

2

2

Substrate-

Level

Phosphorylation

Pyruvate Kinase

2

net atp production by complete glucose oxidation
Net ATP Production byComplete Glucose Oxidation

Aerobic glycolysis: 8 ATP

Oxidative decarboxylation: 2 X 3 = 6 ATP

Krebs cycle: 2 X 12 = 24 ATP

Net: 38 ATP

take home message
Take Home Message
  • Pyruvate is oxidativelydecarboxylated by PDH to acetyl CoA inside the mitochondria
  • Krebs cycle:
    • Final common pathway for the oxidation of carbohydrates, fatty acids and amino acids
    • occurs in the mitochondria
    • Aerobic
    • Mainly catabolic, with some anabolic reactions
  • The complete oxidation of one glucose molecule results in a net production of 38 ATP molecules
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