Regulating the cell cycle
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Honors Biology Chapter10 Section 3 SC B-2.7: Summarize how cell regulation controls & coordinates cell growth & division & allows cells to respond to the environment, and recognize the consequences of uncontrolled cell division. Regulating the cell cycle. Essential Question.

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Regulating the cell cycle

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Regulating the cell cycle

Honors Biology Chapter10 Section 3

SC B-2.7: Summarize how cell regulation controls & coordinates cell growth & division & allows cells to respond to the environment, and recognize the consequences of uncontrolled cell division

Regulating the cell cycle


Essential question

Essential Question

  • How does cancer happen?


Cell cultures

Cell Cultures

  • Cells in a petri dish with appropriate nutrients will continue to grow until they come in contact with other cells: called

  • Contact Inhibition


Contact inhibition

Contact Inhibition

  • similar controls in body

  • occurs in wound healing


Cell cycle its regulators

Cell Cycle & Its Regulators


Cell cycle regulators cyclins

Cell Cycle Regulators: Cyclins

  • regulators are cell proteins (cyclins)

    • regulate timing of cell cycle in eukaryotic cells

  • dozens other proteins since discovered

  • Internal Regulators

  • External Regulators


Internal regulators

Internal Regulators

  • proteins that respond to events inside the cell

  • allow cell cycle to proceed once certain processes have been completed inside cell


External regulators

External Regulators

  • proteins that respond to events outside cell

  • direct rate of cell division

  • most important ones:

  • Growth Factors

    • important in embryonic development

    • also used in wound healing


Uncontrolled cell division cancer

Uncontrolled Cell Division Cancer

  • cancer: disorder in which some of an organisms cells have lost ability to control growth

  • Cancer cells do not respond to signals that regulate cell division


Cancer cells have loss of contact inhibition

Cancer Cells have Loss of Contact Inhibition


Causes of loss of control

Causes of Loss of Control???

  • appears to have many causes:

    • carcinogens

      • some affect internal regulators, some external regulators

    • defect in gene p53


Carcinogens

Carcinogens

  • Nicotine

  • Viruses

    • Hepatitis

    • Human Papilloma Virus (HPV)

    • Bovine Papilloma Virus

    • Tobacco Virus

  • Radiation


Cancer cells

Cancer Cells


Skin cells

Skin Cells


Stomach cells

Stomach Cells


Hela cells

HeLa Cells

  • Henrietta Lacks died of cervical cancer in Johns Hopkins Hospital, Baltimore, MD in 1950’s

  • Biopsies of her cervix taken to researchers @Johns Hopkins where they were cultured &they are still growing!


Hela cells1

HeLa Cells

  • used in multiple medical areas:

    • development of Polio Vaccine

    • trip to the moon : What is the effect of weightlessness on rate of cell growth/division ?

    • cell cloning

    • gene mapping

    • hybrid cell lines


Hela cells2

HeLa Cells


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