Regulating the cell cycle
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Honors Biology Chapter10 Section 3 SC B-2.7: Summarize how cell regulation controls & coordinates cell growth & division & allows cells to respond to the environment, and recognize the consequences of uncontrolled cell division. Regulating the cell cycle. Essential Question.

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Regulating the cell cycle

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Honors Biology Chapter10 Section 3

SC B-2.7: Summarize how cell regulation controls & coordinates cell growth & division & allows cells to respond to the environment, and recognize the consequences of uncontrolled cell division

Regulating the cell cycle


Essential Question

  • How does cancer happen?


Cell Cultures

  • Cells in a petri dish with appropriate nutrients will continue to grow until they come in contact with other cells: called

  • Contact Inhibition


Contact Inhibition

  • similar controls in body

  • occurs in wound healing


Cell Cycle & Its Regulators


Cell Cycle Regulators: Cyclins

  • regulators are cell proteins (cyclins)

    • regulate timing of cell cycle in eukaryotic cells

  • dozens other proteins since discovered

  • Internal Regulators

  • External Regulators


Internal Regulators

  • proteins that respond to events inside the cell

  • allow cell cycle to proceed once certain processes have been completed inside cell


External Regulators

  • proteins that respond to events outside cell

  • direct rate of cell division

  • most important ones:

  • Growth Factors

    • important in embryonic development

    • also used in wound healing


Uncontrolled Cell Division Cancer

  • cancer: disorder in which some of an organisms cells have lost ability to control growth

  • Cancer cells do not respond to signals that regulate cell division


Cancer Cells have Loss of Contact Inhibition


Causes of Loss of Control???

  • appears to have many causes:

    • carcinogens

      • some affect internal regulators, some external regulators

    • defect in gene p53


Carcinogens

  • Nicotine

  • Viruses

    • Hepatitis

    • Human Papilloma Virus (HPV)

    • Bovine Papilloma Virus

    • Tobacco Virus

  • Radiation


Cancer Cells


Skin Cells


Stomach Cells


HeLa Cells

  • Henrietta Lacks died of cervical cancer in Johns Hopkins Hospital, Baltimore, MD in 1950’s

  • Biopsies of her cervix taken to researchers @Johns Hopkins where they were cultured &they are still growing!


HeLa Cells

  • used in multiple medical areas:

    • development of Polio Vaccine

    • trip to the moon : What is the effect of weightlessness on rate of cell growth/division ?

    • cell cloning

    • gene mapping

    • hybrid cell lines


HeLa Cells


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