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Honors Biology Chapter10 Section 3 SC B-2.7: Summarize how cell regulation controls & coordinates cell growth & division & allows cells to respond to the environment, and recognize the consequences of uncontrolled cell division. Regulating the cell cycle. Essential Question.

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regulating the cell cycle

Honors Biology Chapter10 Section 3

SC B-2.7: Summarize how cell regulation controls & coordinates cell growth & division & allows cells to respond to the environment, and recognize the consequences of uncontrolled cell division

Regulating the cell cycle

essential question
Essential Question
  • How does cancer happen?
cell cultures
Cell Cultures
  • Cells in a petri dish with appropriate nutrients will continue to grow until they come in contact with other cells: called
  • Contact Inhibition
contact inhibition
Contact Inhibition
  • similar controls in body
  • occurs in wound healing
cell cycle regulators cyclins
Cell Cycle Regulators: Cyclins
  • regulators are cell proteins (cyclins)
    • regulate timing of cell cycle in eukaryotic cells
  • dozens other proteins since discovered
  • Internal Regulators
  • External Regulators
internal regulators
Internal Regulators
  • proteins that respond to events inside the cell
  • allow cell cycle to proceed once certain processes have been completed inside cell
external regulators
External Regulators
  • proteins that respond to events outside cell
  • direct rate of cell division
  • most important ones:
  • Growth Factors
    • important in embryonic development
    • also used in wound healing
uncontrolled cell division cancer
Uncontrolled Cell Division Cancer
  • cancer: disorder in which some of an organisms cells have lost ability to control growth
  • Cancer cells do not respond to signals that regulate cell division
causes of loss of control
Causes of Loss of Control???
  • appears to have many causes:
    • carcinogens
      • some affect internal regulators, some external regulators
    • defect in gene p53
carcinogens
Carcinogens
  • Nicotine
  • Viruses
    • Hepatitis
    • Human Papilloma Virus (HPV)
    • Bovine Papilloma Virus
    • Tobacco Virus
  • Radiation
hela cells
HeLa Cells
  • Henrietta Lacks died of cervical cancer in Johns Hopkins Hospital, Baltimore, MD in 1950’s
  • Biopsies of her cervix taken to researchers @Johns Hopkins where they were cultured &they are still growing!
hela cells1
HeLa Cells
  • used in multiple medical areas:
    • development of Polio Vaccine
    • trip to the moon : What is the effect of weightlessness on rate of cell growth/division ?
    • cell cloning
    • gene mapping
    • hybrid cell lines
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