HPT axis. Review of HPA. Hypothalamus receives multiple signals from various regions of the brain Hypothalamus can directly release hormones into bloodstream in posterior pituitary via neurons or;
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Parafollicular cell “C-cell”
When TSH is released, thyroglobulin molecules form colloid droplets and are taken back up into follicular cells by endocytosis
Colloid droplets fuse with lysosomes hydrolysis of Tg T3 and T4 are released
About 10% T4 converted to T3 before secretion
T4 and T3 containing vesicles are excreted out to blood stream