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DNA 의 구조

DNA 의 구조. DNA Structure. DNA- 유전물질. Avery & his colleague(1944) Transformation in Pneumococcus 에서 처음으로 DNA 가 유전물질임을 시사 Hershey & Chase(1952) T2 phage 에서 유전물질이 단백질이 아닌 DNA 임을 증명. Nucleotide. nitrogen base purine base: adenine & guanine pyrimidine base: thymine & cytocine

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DNA 의 구조

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  1. DNA의 구조 DNA Structure

  2. DNA-유전물질 • Avery & his colleague(1944) Transformation in Pneumococcus에서 처음으로 DNA가 유전물질임을 시사 • Hershey & Chase(1952) T2 phage에서 유전물질이 단백질이 아닌 DNA임을 증명

  3. Nucleotide • nitrogen base purine base: adenine & guanine pyrimidine base: thymine & cytocine • ribose • phosphoric acid

  4. 당(Sugar)

  5. 인산 (Phosphate)

  6. 염기(Base)

  7. Franklin & Wilkins

  8. X-ray diffraction

  9. DNA 분자구조의 특징 • Highly regular fashion • duplex(helical chain) • A-T & C-G (Chagaffe's law) • Reference Watson, J. D. and Crick, F. H. C. 1953. Molecular structure of nucleic acid; A structure for deoxyribose nucleic acid. Nature 171:737

  10. 사람의 nucleotide의 수: 약 32억 b.p. • 생성가능한 변이의 수:432억 • 길이: 3x106개의 nucleotide가 1mm • 따라서 30억/300백만=1000mm=1m

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