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第八章 相转移催化技术在药物合成中的应用 PowerPoint PPT Presentation


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第八章 相转移催化技术在药物合成中的应用. 制药工程教研室 李丽娟. 工作任务 : 采用 相转移催化技术 合成药物及中间体 学习目标 : 1. 了解相转移催化反应的原理 2. 熟悉常用相转移催化剂、影响相转移催化反应的主要因素 3. 掌握 典型 相转移催化技术的操作方法 4. 了解相转移催化技术在科研与生产中的应用与发展。. 一、相转移催化的原理. 条件一:. 有一个互不相溶的 二相系统 , 其中一相(一般是水相)含有亲核试剂的盐类;另一相为有机相,其中含有与上述盐类起反应的有机作用物。. 条件二:.

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第八章 相转移催化技术在药物合成中的应用

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CNQ+


1

  • ;

  • RR


2

1: R4N+X


(CH3)4NBr

(C3H7)4NBr

(C4H9)4NBr

(C4H9)4NI

(C4H9)4NCl

(C2H5)3C6H5CH2NCl

(C2H5)3C6H5CH2NBr

(C4H9)4NHSO4

TMAB

TPAB

TBAB

TBAI

TBAC

TEBAC

TEBAB

TBAHS

(C8H17)3NCH3Cl

C6H13N(C2H5)3Br

C8H17N(C2H5)3Br

C10H21N(C2H5)3Br

C12H25N(C2H5)3Br

C16H33N(C2H5)3Br

C16H33N(CH3)3Br

(C8H17)3NCH3Br

TOMAC

HTEAB

OTEAB

DTEAB

LTEAB

CTEAB

CTMAB

TOMAC


2


3

  • HOCH2CH2OnH

  • C12H25OCH2CH2OnH

  • C3H7C6H4OCH2CH2OnH


  • KFKMnO4

  • --


1


  • ABAB3.5

2

05~10%


3


1C-


CH3I

C2H5Br

C6H5CH2Cl

NaNH2/NH3

PTC*

NaNH2/NH3

PTC*

NaNH2/NH3

PTC*

A

21

5

15

6

29

22

B

50

89

70

90

33

50

C

19

4

15

4

30

19


2O-

Williamson

PTCNaOH


  • Cannizaro25%37%



50%NaoH

TEBA

562

  • dl-

    NaCN



TRC



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