Characterization of the morphological, phenotypic, and molecular effects of 17 α -ethynylestradiol exposure during early development in Xenopus laevis. Amber Tompsett , Steve Wiseman, Eric Higley , Hong Chang John P. Giesy , and Markus Hecker. Toxicology Centre, University of Saskatchewan.
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Characterization of the morphological, phenotypic, and molecular effects of 17α-ethynylestradiol exposure during early development in Xenopus laevis
Amber Tompsett, Steve Wiseman, Eric Higley, Hong Chang John P. Giesy, and Markus Hecker
Toxicology Centre, University of Saskatchewan
SETAC North America Annual Meeting
Portland, OR, USA
November 7-11, 2010
*Estrogen equivalent concentrations in surface water normally range from 3-30 ng/L
Survival analysis followed by ANOVA, post-hoc Tukey’s test; significant differences (p<0.05) denoted by different letters
Fisher’s Exact Tests; significant differences denoted by different letters
*Initial data from a subsample of EE2 treated animals.
22 genes upregulated at least 15-fold
66 genes downregulated at least 15-fold
Additional Ongoing Analysis