Platelet and global haemostatic effects of common traditional Chinese herbal medicines:
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Platelet and global haemostatic effects of common traditional Chinese herbal medicines: implications for anaesthesia. KFJ Ng May 2011. 5. 22 (2000) 13 (2003). 7. 8 (2006) 13 (2005). 7 (2007) 14 (2004). Ann Pharmacother 2004;38:1651. The “Big 3”. Ginkgo biloba (7/29) Garlic (3/29)

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KFJ Ng May 2011

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Platelet and global haemostatic effects of common traditional Chinese herbal medicines: implications for anaesthesia

KFJ Ng

May 2011


5

22 (2000)

13 (2003)

7

8 (2006)

13 (2005)

7 (2007)

14 (2004)


Ann Pharmacother 2004;38:1651


The “Big 3”

  • Ginkgo biloba (7/29)

  • Garlic (3/29)

  • Saw palmetto (2/29)


Ginkgo biloba

Am J Hematol 2005; 79: 343


Ginkgo biloba (EGb 761)

Thromb Res 2003; 108: 151


Garlic

A&A 2007; 105: 1214


Garlic

Prostaglandins Leukot Essent Fatty Acids 1998;58:257


Saw palmetto


The “Big 3” and more…

Plast Reconstr Surg 2007; 120:2044


Fufang (compound formula)


Danshen (丹參, salvia root)


Danshen (丹參, salvia root)

Platelets 2008;19:24


Danshen (丹參, salvia root)

Thromb Res 2008;123:298


Ligusticum wallichii (chuanxiong, Szechuan lovage, “川芎”)


Ligusticum wallichii (chuanxiong, Szechuan lovage, “川芎”)

Thromb Res 2001;104:15


Curcuma zedoaria (zedoary, ezhu, “莪朮”)


Curcuma zedoaria (zedoary, ezhu, “莪朮”)

Thromb Res 2011;127:111


Curcuma zedoaria (zedoary, ezhu, “莪朮”)

Thromb Res 2011;127:111


Angelica Sinensis (dongguai, “當歸”)


Dang-Gui-Shao-Yao-San (當歸芍藥散)(dong guai, chuanxiong, and others)

Am J Chin Med 2005;33:747


Radix et Rhizoma Notoginseng (sanqi, “三七”)


Radix et Rhizoma Notoginseng(sanqi, “三七”)

J Clin Pharmacol 2000;40:1150


Radix et Rhizoma Notoginseng (sanqi, “三七”)

Pharmacotherapy 2001;21:773


Radix et Rhizoma Notoginseng(sanqi, “三七”)

J Ethnopharmacol 2009;125:380


Radix et Rhizoma Notoginseng(sanqi, “三七”)

J Ethnopharmacol 2009;125:380


Radix et Rhizoma Notoginseng(sanqi, “三七”)

J Ethnopharmacol 2009;125:380


  • Get to know the “bad guys”

  • Know the common ones used in your locality

  • Back to the basics

  • Haemostasis testing


Can you tell me…

  • Indication for treatment?

  • Drug interactions?

  • Precautions e.g. menstruation?

  • Bleeding symptoms


Printer

LCD screen

Soft keys

Trigger solution

Test

cartridge

Cassette

Carousel


EPICT = 188 sec

Sensitivity = 88%

Specificity = 52%


Thank You


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