Platelet and global haemostatic effects of common traditional Chinese herbal medicines:
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Platelet and global haemostatic effects of common traditional Chinese herbal medicines: implications for anaesthesia. KFJ Ng May 2011. 5. 22 (2000) 13 (2003). 7. 8 (2006) 13 (2005). 7 (2007) 14 (2004). Ann Pharmacother 2004;38:1651. The “Big 3”. Ginkgo biloba (7/29) Garlic (3/29)

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KFJ Ng May 2011

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Kfj ng may 2011

Platelet and global haemostatic effects of common traditional Chinese herbal medicines: implications for anaesthesia

KFJ Ng

May 2011


Kfj ng may 2011

5

22 (2000)

13 (2003)

7

8 (2006)

13 (2005)

7 (2007)

14 (2004)


Kfj ng may 2011

Ann Pharmacother 2004;38:1651


The big 3

The “Big 3”

  • Ginkgo biloba (7/29)

  • Garlic (3/29)

  • Saw palmetto (2/29)


Ginkgo biloba

Ginkgo biloba

Am J Hematol 2005; 79: 343


Ginkgo biloba egb 761

Ginkgo biloba (EGb 761)

Thromb Res 2003; 108: 151


Garlic

Garlic

A&A 2007; 105: 1214


Garlic1

Garlic

Prostaglandins Leukot Essent Fatty Acids 1998;58:257


Saw palmetto

Saw palmetto


The big 3 and more

The “Big 3” and more…

Plast Reconstr Surg 2007; 120:2044


Fufang compound formula

Fufang (compound formula)


Danshen salvia root

Danshen (丹參, salvia root)


Danshen salvia root1

Danshen (丹參, salvia root)

Platelets 2008;19:24


Danshen salvia root2

Danshen (丹參, salvia root)

Thromb Res 2008;123:298


Ligusticum wallichii chuanxiong szechuan lovage

Ligusticum wallichii (chuanxiong, Szechuan lovage, “川芎”)


Ligusticum wallichii chuanxiong szechuan lovage1

Ligusticum wallichii (chuanxiong, Szechuan lovage, “川芎”)

Thromb Res 2001;104:15


Curcuma zedoaria zedoary ezhu

Curcuma zedoaria (zedoary, ezhu, “莪朮”)


Curcuma zedoaria zedoary ezhu1

Curcuma zedoaria (zedoary, ezhu, “莪朮”)

Thromb Res 2011;127:111


Curcuma zedoaria zedoary ezhu2

Curcuma zedoaria (zedoary, ezhu, “莪朮”)

Thromb Res 2011;127:111


Angelica sinensis dongguai

Angelica Sinensis (dongguai, “當歸”)


Dang gui shao yao san dong guai chuanxiong and others

Dang-Gui-Shao-Yao-San (當歸芍藥散)(dong guai, chuanxiong, and others)

Am J Chin Med 2005;33:747


Radix et rhizoma notoginseng sanqi

Radix et Rhizoma Notoginseng (sanqi, “三七”)


Radix et rhizoma notoginseng sanqi1

Radix et Rhizoma Notoginseng(sanqi, “三七”)

J Clin Pharmacol 2000;40:1150


Radix et rhizoma notoginseng sanqi2

Radix et Rhizoma Notoginseng (sanqi, “三七”)

Pharmacotherapy 2001;21:773


Radix et rhizoma notoginseng sanqi3

Radix et Rhizoma Notoginseng(sanqi, “三七”)

J Ethnopharmacol 2009;125:380


Radix et rhizoma notoginseng sanqi4

Radix et Rhizoma Notoginseng(sanqi, “三七”)

J Ethnopharmacol 2009;125:380


Radix et rhizoma notoginseng sanqi5

Radix et Rhizoma Notoginseng(sanqi, “三七”)

J Ethnopharmacol 2009;125:380


Kfj ng may 2011

  • Get to know the “bad guys”

  • Know the common ones used in your locality

  • Back to the basics

  • Haemostasis testing


Can you tell me

Can you tell me…

  • Indication for treatment?

  • Drug interactions?

  • Precautions e.g. menstruation?

  • Bleeding symptoms


Kfj ng may 2011

Printer

LCD screen

Soft keys

Trigger solution

Test

cartridge

Cassette

Carousel


Kfj ng may 2011

EPICT = 188 sec

Sensitivity = 88%

Specificity = 52%


Thank you

Thank You


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