“生理科学实验”之研究性实验汇报
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肢体远距缺血预处理在心肌缺血损伤中具有线粒体保护作用 PowerPoint PPT Presentation


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“生理科学实验”之研究性实验汇报. 肢体远距缺血预处理在心肌缺血损伤中具有线粒体保护作用. 医学院 01 级 基础医学专业 沈方 沈倩 许震宇 指导教师:夏强 高琴 陆源. BACKGROUND. 肢体局部组织短暂性缺血 心肌保护效应. 线粒体. 远距离预处理. 调控细胞“生死”的关键. ?. 心肌保护效应. 线粒体. 远距离预处理. METHODS. 远端缺血预处理. 离体心脏缺氧. 分离线粒体. 测量吸光度的改变. Specific procedures. RESULTS. A bsorbance change.

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肢体远距缺血预处理在心肌缺血损伤中具有线粒体保护作用

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6014653

“生理科学实验”之研究性实验汇报

肢体远距缺血预处理在心肌缺血损伤中具有线粒体保护作用

医学院 01级 基础医学专业

沈方 沈倩 许震宇

指导教师:夏强 高琴 陆源


Background

BACKGROUND

肢体局部组织短暂性缺血

心肌保护效应

线粒体

远距离预处理

调控细胞“生死”的关键

心肌保护效应

线粒体

远距离预处理


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METHODS

远端缺血预处理

离体心脏缺氧

分离线粒体

测量吸光度的改变


Specific procedures

Specific procedures


Results

RESULTS

Absorbance change

Remote Preconditioning of the lower limb can prevent mitochondria swelling


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A’520 reduction

**P < 0.01vs.Control A’520=A520/A520Max


Mda production

MDA production

Not enough data for statistical analysis


Conclusion

Conclusion

  • 远距离缺血预处理可在心肌缺血损伤过程中保护线粒体

  • 远距离缺血预处理可减轻心肌缺血过程中的脂质过氧化水平

  • 线粒体可能是远距离缺血预处理所产生的各种心肌保护因素的重要靶点


Possible mechanism

Possible mechanism

Ischemia

RPC

Ca2+

Humour factors

Nervous factors

Mitochondria

swelling

Mitochondria keeps intact

Oxidants

(ROS)

other targets ?

Necrosis

ATP

Cyto C release

Cardioprotective effect

Apoptosis


Perspective

Perspective

  • 进一步明确参与RPC保护作用的各种神经体液因素

  • 探讨各种因素是如何作用于线粒体并产生相应效应

  • 阐明RPC保护效应的内在机制


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Thank you!

2005.1.11


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