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CJD and Kuru: Prion Viruses. By: Danny Nemeth. Prion. infectious agent composed of protein in a misfolded form. CJD. Creutzfeldt-Jakob Disease neurodegenerative disorder year of onset of illness. Structure. no Nucleic acids mass of 27,000 - 30,000 daltons 145 amino acids

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Presentation Transcript
prion
Prion
  • infectious agent composed of protein in a misfolded form
slide3
CJD
  • Creutzfeldt-Jakob Disease
  • neurodegenerative disorder
  • year of onset of illness
structure
Structure
  • no Nucleic acids
  • mass of 27,000 - 30,000 daltons
  • 145 amino acids
  • Structure unknown
cause
Cause
  • promotes refolding of native proteins
  • mass of misfolded proteins disrupts cell function
symptoms
Symptoms
  • Neurological
    • Depression
    • Confusion
    • loss of coordination and balance
    • progressive blindness
transmission
Transmission
  • GENETICS!
  • Defective HGH
  • CANNIBALISM!
slide9
KURU
  • Misfolded Proteins
  • Cannibalism
    • Brains
symptoms1
Symptoms
  • Coordination problems
  • Difficulty walking
  • Swallowing difficulty
  • Tremors and muscle jerks
treatment and prognosis
Treatment and Prognosis
  • NONE! 
  • Prognosis
    • Death after 1 year of symptoms
stuff i used
Stuff I Used
  • http://www.cjdsurveillance.com/abouthpd.html
  • http://www.cdc.gov/ncidod/dvrd/cjd/index.htm
  • http://en.wikipedia.org/wiki/Kuru_(disease)
  • http://en.wikipedia.org/wiki/Creutzfeldt%E2%80%93Jakob_disease
  • http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0002355/
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