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CHVI/CIDA. GHRI/CHVI/CIDA/IDRC /CIHR. Afri -Can Synchronicity Forum 17-19 Jan. 2012, Entebbe. Sophia Osawe (BSc, AIMLS) Institute of Human Virology, Nigeria Nigerian Canadian Collaboration on AIDS Vaccines (NICCAV) Study Coordinator.

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Sophia Osawe (BSc, AIMLS) Institute of Human Virology, Nigeria

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Sophia osawe bsc aimls institute of human virology nigeria

CHVI/CIDA

GHRI/CHVI/CIDA/IDRC/CIHR

  • Afri-Can Synchronicity Forum 17-19 Jan. 2012, Entebbe

Sophia Osawe (BSc, AIMLS)

Institute of Human Virology, Nigeria

Nigerian Canadian Collaboration on AIDS Vaccines (NICCAV)

Study Coordinator

Discordant Couples Cohort Is Still Relevant For HIV Vaccine Studies Despite Low Transmission Rates;

Canadian–Nigerian Experience


Background

Background

GHRI/CHVI/CIDA/IDRC/CIHR

Discordant couples have been known to be medium risk group for HIV transmission.

This group is suitable for HIV vaccine trials due to:

  • the natural exposure

  • high retention rates recorded in the past.

    A cohort of HIV sero-negative volunteers of discordant couples has been developed in Nigeria to record :

    behavioral data, risk factors, HIV incidence, STI infections, and retention rates.


Study flow

Study flow

GHRI/CHVI/CIDA/IDRC/CIHR

*Counseling

*Referrals

(community)

Screening

(Eligibility criteria)

No

Eligible?

Sero-discordance

STOP

Yes

Consent & Enroll

  • ● Behavioral data ●Medical history/exams ●Serology tests ●Safety Labs

Medical examination and labs supporting HIV+ partners

11 study visits (2 years FU)

Complete


Methods

Methods

GHRI/CHVI/CIDA/IDRC/CIHR

Laboratory:

HIV negative

  • Serology tests

  • Safety Labs- CBC, LFT and KFT

    Clinical:

  • Medical History and Examinations

  • Referrals to appropriate clinics

    HIV positive partners-

  • CD4 counts (PartecCyflow SL3 counter)

  • Viral Loads (ROCHE COBAS Taqman 96; HIV v2.0)


Results risk factors

Results- Risk Factors

GHRI/CHVI/CIDA/IDRC/CIHR


Results risk factors hiv partners

Results- Risk factors (HIV+ partners)

GHRI/CHVI/CIDA/IDRC/CIHR

HIV incidence :

The recorded incidence in this cohort is 0.6%


Conclusion

Conclusion

GHRI/CHVI/CIDA/IDRC/CIHR

  • Despite antiretroviral treatment, sero- negative partners are still at risk of getting infected mainly due to:

    • Inconsistent and lack of condom use.

    • A high percentage of sero-positive partners still have detectable viral loads.

    • Prevailing STIs among HIV negative and HIV positive partners

  • Sero-discordant couple cohort remains an important natural adult model for transmission studies; and

  • ..presents an opportunity to test vaccines in HIV exposed adults


  • Acknowledgements

    Acknowledgements

    GHRI/CHVI/CIDA/IDRC/CIHR

    This work was carried out with support from the Global Health Research Initiative (GHRI), a research funding partnership composed of the Canadian Institutes of Health Research, the Canadian International Development Agency, and the International Development Research Centre.

    • PLASVIREC’s Research team: Counseling, Clinical, Data & Lab team

    • All the discordant couples that

      volunteered for this study

    • Dr. Pam Datong

    • Dr. EvaeziOkpokoro

    • Dr. Alash’le Abimiku


    Sophia osawe bsc aimls institute of human virology nigeria

    GHRI/CHVI/CIDA/IDRC/CIHR


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