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Announcements. Is this your clicker ID number? 6F28B 19B953 If so, please see me so I can put a name with the number. Clicker Quiz 1 on Monday (1/23): will cover key terms and concepts list 2 from Chapter 4 (see course website) . BIO 304 Lecture 4.

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  1. Announcements Is this your clicker ID number? 6F28B 19B953 If so, please see me so I can put a name with the number Clicker Quiz 1 on Monday (1/23): will cover key terms and concepts list 2 from Chapter 4 (see course website)

  2. BIO 304 Lecture 4

  3. I. Practice problem: how many gametes or genotypes? How many different gametes can be generated from individuals with the following genotypes? 1. AaBbCc 2. AaBbCcDD How many different genotypes will be produced from the following crosses? 1. AaBbCc X AaBbCc 2. AaBbCc X aabbcc

  4. II. Pedigree analysis

  5. Pedigree of an autosomal recessive trait Mendelian rules apply, but Mendelian ratios are not observed b/c of small sample size Examples: cystic fibrosis, sickle-cell anemia, albinism, Tay-Sachs disease, PKU

  6. Consanguineous marriages can increase the appearance of recessive phenotypes

  7. Pedigree of a dimorphic trait tasters: chemical PTC tastes bitter nontasters: cannot taste PTC at all

  8. Pedigree for an autosomal dominant trait Examples: Huntington’s disease, pseudoachondroplasia (dwarfism), spinocerebellar ataxia type I (SCA1), Marfan’s syndrome, Ehlers-Danlos syndrome, familial hypercholesterolemia, polydactyly

  9. Pedigrees and probability Conditional probability The pedigree below represents the occurrence of cystic fibrosis, a rare autosomal disease. What is the probability that the offspring represented by the question mark will have cystic fibrosis?

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  11. Using the binomial theorem Two parents are both heterozygous carriers of the autosomal recessive gene that causes Tay-Sachs disease. If the couple has five children, what is the probability that exactly two of the children will have Tay-Sachs disease? Tay Sachs

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