1 / 23

Beginning of the chapter

30. Beginning of the chapter. Oxidative stress, substances and genetics (Toxo Sensor). OXIDATIVE STRESS. Free radicals damage the cells. OXIDATIVE STRESS. Free radicals. AGEING CANCER. OXIDATIVE STRESS. Free radicals damage the cells. 5% oxygen. SOD2. Superoxide. MITOCHONDRIA. SOD3.

chandler
Download Presentation

Beginning of the chapter

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. 30 Beginning of the chapter Oxidative stress, substances and genetics (Toxo Sensor)

  2. OXIDATIVE STRESS Free radicals damage the cells OXIDATIVE STRESS Free radicals AGEING CANCER

  3. OXIDATIVE STRESS Free radicals damage the cells 5% oxygen SOD2 Superoxide MITOCHONDRIA SOD3 SOD1 Hydrogen peroxide CYTOPLASM OF A CELL

  4. OXIDATIVE STRESS Free radicals

  5. OXIDATIVE STRESS GPX1 – a selenoprotein Selenium GPX1 GPX1 Free radicals

  6. OXIDATIVE STRESS GPX1 – a selenoprotein GPX1 GPX1 Selenium Free radicals

  7. OXIDATIVE STRESS GPX1 – a selenoprotein GPX1 GPX1 Selenium

  8. OXIDATIVE STRESS GPX1 – a selenoprotein GPX1 GPX1 Selenium Neutralised

  9. OXIDATIVE STRESS Selenium deficiency and GPX1 Selenium deficiency 30% Activity More selenium 70% Activity

  10. OXIDATIVE STRESS Polymorphism in the GPX1 gene GPX1 GPX1 Free radicals

  11. OXIDATIVE STRESS Polymorphism in the GPX1 gene GPX1 GPX1 Selenium Free radicals

  12. OXIDATIVE STRESS Polymorphism in the GPX1 gene GPX1 GPX1 Poorer binding (for example, 50% worse) Selenium

  13. OXIDATIVE STRESS Polymorphism in the GPX1 gene Normal levels of Selenium 35% Activity More selenium 60% Activity

  14. OXIDATIVE STRESS Free radicals

  15. OXIDATIVE STRESS Coenzyme Q10 Q10 – No effect Q10 NQO1 Q10 Ubiquinol antioxidant effect Free radicals UBI UBI

  16. OXIDATIVE STRESS Free radicals

  17. OXIDATIVE STRESS Coenzyme Q10 Q10 – No effect Q10 NQO1 Q10 UBI UBI UBI Free radicals UBI UBI UBI UBI

  18. OXIDATIVE STRESS Coenzyme Q10 Q10 – No effect Q10 NQO1 Q10 E C E E Free radicals ALA C C ALA E ALA

  19. OXIDATIVE STRESS Oxidative stress, what to do now?

  20. OXIDATIVE STRESS Oxidative stress, what to do now? • RECOMMENDATIONS • Antioxidant-rich diet • Additional intake of free-radical scavengers • Vitamin C • Vitamin E • ß-carotene • Alpha lipoic acid • Coenzyme Q10? Ubiquinol? • Selenium – how much? GPX1-gene • 2 Cups of coffee/day for 7 delay of the breast cancer occurrence?

  21. SUBSTANCES The effect of various substances on our body

  22. SUBSTANCES The effect of various substances on our body

  23. 30 End of the chapter Oxidative stress, substances and genetics (Toxo Sensor)

More Related