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Early Phase Clinical Trial Network. UKMF Spring Day - 13 March 2013. Strategic The most pertinent clinical studies are identified based on Key Objectives and developed and prioritised by a Steering Group of myeloma specialists. Collaborative

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Early Phase Clinical Trial Network

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Early phase clinical trial network

Early Phase

Clinical Trial Network

UKMF Spring Day

- 13 March 2013


Early phase clinical trial network

Strategic

The most pertinent clinical studies are identified based on Key Objectives and developed and prioritised by a Steering Group of myeloma specialists.

Collaborative

Stakeholders throughout the NHS, HTA, Patients and the Pharmaceutical Industry work together to implement the most effective clinical trial design and ensure effective adoption of data.

Efficient

Working as a network, coordinated via a central office with standard processes and procedures and working with NHS and industry stakeholders, the CTN aims to break down the barriers that delay research enabling studies to be delivered quickly and effectively.

CTN Objectives


Early phase clinical trial network

Leeds Clinical Trials

Coordinating Office

Bringing Stakeholders Together

Clinical Experts


Early phase clinical trial network

Leeds Clinical Trials

Coordinating Office

St James’s,

Leeds

City,

Nottingham

QE,

Birmingham

The Christie,

Manchester

RMH,

London

UCLH,

London

King’s,

London

Bart’s,

London

R Hallamshire

Sheffield

General H,

Southampton

Uni H Wales,

Cardiff

Uni Hospital,

Oxford

CTN Network

Central Trial Office

8 Core Active

Trial Centres

4 Additional

Centres

Expansion

inc. Scotland

& N Ireland


Early phase clinical trial network

Other areas include:

Improving the setting for adoption of non-commercial data

Making best use of available resources, especially patients

Promote novel clinical trial designs

Supporting novel approaches to licensing e.g. adaptive licensing

Developing novel drug life-cycle strategies

Addressing health economic barriers

Collaboration with pharmaceutical companies

Development of “Pathways Model” to identify future optimum therapy

CTN is part of a wider objective

CTN trials are one part of a wider Myeloma UK objective to impact how clinical trial data is generated and adopted, to more effectively bring optimum treatments to patients.


Early phase clinical trial network

Personalised Medicine

Individualised treatment based on diagnostic biomarkers (i.e. genetic subgroups)

Individualised treatment based on clinical presentation (clinical subgroups e.g. elderly/frail, high risk)

Access to Treatments

Promoting novel treatments

Identifying evidence gaps for drugs currently in development that may prevent or delay them being approved by NICE and/or taken into UK practice.

Planning studies around expected life-cycle of a drug in real world setting

Strategic Approach to Selecting Trials

CTN trials are identified and prioritised based on two objectives:


Early phase clinical trial network

Current Portfolio of MUK Trials


Early phase clinical trial network

CI and Co-Investigators


Early phase clinical trial network

Biobanking

Personalised Medicine

Programme

Clinical Trial Network

Myeloma Research

Centres

Diagnostics

Linking the CTN with Discovery Research


Early phase clinical trial network

Why the MUK CTN important

Patients are waiting…

Myeloma patients need more effective treatments with less side-effects.

In order to deliver this in the soonest possible time frame, we have set up

the CTN to be more efficient and more effective.

We must challenge the hurdles and the inefficiencies and strive for

improvements in the system.


Early phase clinical trial network

“Our Clinical Trial Network is a groundbreaking approach to clinical research in the UK. It is strategic, efficient and collaborative. Our model of engaging with stakeholders and breaking down barriers is not only changing the course of myeloma research, but could transform the way in which new treatments for other rare cancers are tested and accessed.”

Eric Low OBE, CEO Myeloma UK


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