Gbs lymphocyte biology
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GBS Lymphocyte Biology. When is the class? Monday, Wednesday, Friday 8am Shelby 105 There is no class on Monday January 17 th , but class will instead be held on Tuesday January 18 th . The last class is on January 28 th. What will be covered in the class?.

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GBS Lymphocyte Biology

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Gbs lymphocyte biology

GBS Lymphocyte Biology

When is the class?

Monday, Wednesday, Friday

8am

Shelby 105

There is no class on Monday January 17th, but class will instead be held on Tuesday January 18th.

The last class is on January 28th


What will be covered in the class

What will be covered in the class?

  • Each week a different topic related to lymphocyte biology will be covered

  • The material covered will be based on papers with some reviews for background information.


How is the class formatted

How is the class formatted?

  • Each paper will be introduced by an assigned student. The student should clearly outline the rationale for the study and basically overview why the work was initiated.

  • The assigned student will present the first figure of the paper and is also responsible for preparing powerpoint slides of ALL OF THE OTHER FIGURES from the paper.


What happens after figure 1

What happens after figure 1?

  • After the paper has been introduced we will randomly pick students to present the remaining figures and tables (typically one student for each display item).

  • You should emphasize why the experiment was performed, how it was done, how it fits in with the rest of the report and also give the authors’ as well as your own conclusions about the data shown.


Discussion

DISCUSSION!!

  • All students are expected to read all of the papers.

  • Students are expected to actively ask questions and participate in a lively discussion of the figures, papers and topic.

  • You will get out what you put in!


Where can i find the papers

Where can I find the papers?

http://www.microbio.uab.edu/lymphocyte_biology/index.html


Assignments

Assignments


What if i have questions about the class

What if I have questions about the class?

Allan Zajac ([email protected])

Chander Raman ([email protected])

Harry Schroeder ([email protected])

Laurie Harrington ([email protected])


What do you know about cd8 t cell responses

What do you know about CD8 T cell responses?


Gbs lymphocyte biology 1170866

T cells recognize MHC + peptide

CD4+ T cell

CD8+ T cell

TCR

TCR

CD8

CD4

Peptide

Peptide

1

1

2

1

2

2

3

ß2-microglobulin

MHC Class I

MHC Class II

Target Cell

APC


Gbs lymphocyte biology 1170866

CD8+T cell

CD4+T cell

DENDRITIC CELL

CD8+T cell

~

CYTOTOXICITY

~

~

Cytokines


Gbs lymphocyte biology 1170866

Three phases of the CD8 T cell response: Expansion, Contraction, and Maintenance

107

GP33

NP396

GP276

106

NP205

Number of Tetramer+ CD8 T Cells/Spleen

105

104

0

100

200

500

Days Post Infection


Gbs lymphocyte biology 1170866

?

?

e

e

e

e

e

e

e

e

e

e

m

m

m

m

m

n

n

How is T cell memory generated?

naive

effector

memory


Gbs lymphocyte biology 1170866

Short-Lived Effector or Exhausted

CD8 T cell differentiation

Tbet

Blimp-1

Eomes

IL-2 Production

Proliferative Capacity

CD127

Differentiation

Memory Precursor

Tbet

Blimp-1

Eomes

IL-2 Production

Proliferative Capacity

CD127


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