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Degradation of Liquid Embolic Polymer - A Pulsatile Flow Model

Degradation of Liquid Embolic Polymer - A Pulsatile Flow Model. BME 440 Senior Design Project Dr. Strey Dr. Weiliam Chen (customer) Group 1: Sara Goldgraben, Bill Hauser & Mike Savarese September 30 th 2005. Aneurysms. Outpouching of a blood vessel Guglielmi Detachable Coil (invasive)

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Degradation of Liquid Embolic Polymer - A Pulsatile Flow Model

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  1. Degradation of Liquid Embolic Polymer- A Pulsatile Flow Model BME 440 Senior Design Project Dr. Strey Dr. Weiliam Chen (customer) Group 1: Sara Goldgraben, Bill Hauser & Mike Savarese September 30th 2005

  2. Aneurysms • Outpouching of a blood vessel • Guglielmi Detachable Coil (invasive) • New Development Liquid Embolics • Combine recombinant human vascular endothelial growth factor (rh VEGF) with a gelable polymer • Possible polymers  Chitosan to N-Carboxyl Ethyl Chitosan • A combination of chitosan and VEGF

  3. Polymer Model Testing • Initial Parameters • 2D model, 3D model • Water Tight, Transparent, Easy to Maintain • Rigid Vasculature • Simulation of Biological Conditions • Blood • Pulsatile Flow Pump • Future Model Design • Elastic Vasculature • Computer Aided Speckle Interferometry (CASI) • Our Initial Ideas • Flow Pump, Vasculature, Enclosure

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