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第八节、癌发生的多阶段模式学说

第八节、癌发生的多阶段模式学说. 结肠癌发生演进分子模型 突变 突变 突变 APC  DNA  K- ras DCC p 53 转移 LOH 甲基化 突变  LOH   LOH  相关基因 ( 5q ) ( 12p ) ( 18q ) ( 17p ) 结肠腺 早期腺瘤 中期腺瘤 晚期腺瘤  结肠癌 转移 上皮增生 <1cm >1cm 无灶 >1cm 有灶.

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第八节、癌发生的多阶段模式学说

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  1. 第八节、癌发生的多阶段模式学说 结肠癌发生演进分子模型 突变 突变 突变 APC  DNA  K-ras DCC p53 转移 LOH 甲基化 突变  LOH   LOH  相关基因 (5q) (12p) (18q) (17p) 结肠腺 早期腺瘤 中期腺瘤 晚期腺瘤  结肠癌 转移 上皮增生<1cm >1cm无灶 >1cm有灶 恶性肿瘤的发生过程中,环境因素的作用也不可忽视。一些环境因素将促进或抑制某些基因的表达。

  2. 结肠癌发生的分子事件。

  3. 肿瘤发生多接阶段过程,经过两次以上打击。

  4. 总之: • 肿瘤的发生涉及遗传因素和环境因素,多基因参与、多步骤遗传损伤的复杂过程,使正常细胞逐渐恶变成肿瘤细胞,经增殖优势形成肿瘤实体,进一步向体内其它部位播散。 end

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