fmri biological basis and experiment design lecture 15 cbf and localization ii
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fMRI: Biological Basis and Experiment Design Lecture 15: CBF and Localization II. CBF techniques Big veins and big voxels. 1 light year = 5,913,000,000,000 miles?. Harrison, Harel et al., Cerebral Cortex 12:225 (2002). 100  m. Perfusion techniques.

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fmri biological basis and experiment design lecture 15 cbf and localization ii
fMRI: Biological Basis and Experiment DesignLecture 15: CBF and Localization II
  • CBF techniques
  • Big veins and big voxels

1 light year = 5,913,000,000,000 miles?

perfusion techniques
Perfusion techniques
  • FAIR – Flow-sensitive Alternating Inverstion Recovery
  • MOTIVE – MOdulation of TIssue and VEssel signal
  • QUIPSS – QUantitative Imaging of Perfusion using a Single Subtraction
  • QUIPSS-II – QUIPSS ... 2nd version
  • CASL – Continuous Arterial Spin Labeling
  • PASL – Pulsed Arterial Spin Labeling
perfusion asl general idea
Perfusion (ASL) – general idea
  • Water in blood is used as a tracer
  • Two images are measured
    • With inversion of incoming blood
      • Longitudinal magnetization of incoming blood is inverted, and subtracts from total voxel signal
    • Without inversion of incoming blood
  • Difference image indicates
casl vs pasl
CASL vs. PASL
  • Continuous ASL
    • long pulse is applied to neck arteries, so all blood coming into the head is inverted
    • After an appropriate delay (~1 – 2s) for that blood to get to the volume of interest, image is acquired
    • Reference image is taken without inversion pulse
    • Subtraction provides perfusion map
  • Pulsed ASL
    • Inversion is done in slab surrounding slices of interest
    • The rest is the same ...
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