Fmri biological basis and experiment design lecture 15 cbf and localization ii
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fMRI: Biological Basis and Experiment Design Lecture 15: CBF and Localization II. CBF techniques Big veins and big voxels. 1 light year = 5,913,000,000,000 miles?. Harrison, Harel et al., Cerebral Cortex 12:225 (2002). 100  m. Perfusion techniques.

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fMRI: Biological Basis and Experiment Design Lecture 15: CBF and Localization II

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Fmri biological basis and experiment design lecture 15 cbf and localization ii

fMRI: Biological Basis and Experiment DesignLecture 15: CBF and Localization II

  • CBF techniques

  • Big veins and big voxels

1 light year = 5,913,000,000,000 miles?


Fmri biological basis and experiment design lecture 15 cbf and localization ii

Harrison, Harel et al., Cerebral Cortex 12:225 (2002)

100m


Perfusion techniques

Perfusion techniques

  • FAIR – Flow-sensitive Alternating Inverstion Recovery

  • MOTIVE – MOdulation of TIssue and VEssel signal

  • QUIPSS – QUantitative Imaging of Perfusion using a Single Subtraction

  • QUIPSS-II – QUIPSS ... 2nd version

  • CASL – Continuous Arterial Spin Labeling

  • PASL – Pulsed Arterial Spin Labeling


Perfusion asl general idea

Perfusion (ASL) – general idea

  • Water in blood is used as a tracer

  • Two images are measured

    • With inversion of incoming blood

      • Longitudinal magnetization of incoming blood is inverted, and subtracts from total voxel signal

    • Without inversion of incoming blood

  • Difference image indicates


Casl vs pasl

CASL vs. PASL

  • Continuous ASL

    • long pulse is applied to neck arteries, so all blood coming into the head is inverted

    • After an appropriate delay (~1 – 2s) for that blood to get to the volume of interest, image is acquired

    • Reference image is taken without inversion pulse

    • Subtraction provides perfusion map

  • Pulsed ASL

    • Inversion is done in slab surrounding slices of interest

    • The rest is the same ...


Fmri biological basis and experiment design lecture 15 cbf and localization ii

Low res SE

High res SE


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