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IMMUNOCHEMISTRY PROFILES

IMMUNOCHEMISTRY PROFILES. Dr. Thomas Williams. TESTS DISEASES CASES. PARAPROTEIN MONOCLONAL PROTEIN M PROTEIN PROTEIN SPIKE M SPIKE. TESTS. Serum Protein Electrophoresis: Uses. Protein Profile General Medical Diseases Defect Dysproteinemias Humoral Immunodeficiency

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IMMUNOCHEMISTRY PROFILES

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  1. IMMUNOCHEMISTRYPROFILES Dr. Thomas Williams

  2. TESTSDISEASESCASES

  3. PARAPROTEIN MONOCLONAL PROTEIN M PROTEIN PROTEIN SPIKE M SPIKE

  4. TESTS

  5. Serum Protein Electrophoresis: Uses Protein Profile • General Medical Diseases • Defect Dysproteinemias • Humoral Immunodeficiency • Paraprotein Detection

  6. Quantitative Assays: Uses • Confirm protein abnormalities suspected by serum protein electrophoresis • Monitor or follow known conditions • Confirm clinically suspected conditions • Identify paraproteins noted by electrophoresis • Says “Nothing” about monoclonality of immunoglobulins measured

  7. Immunofixational Electrophoresis/ Immunoelectrophoresis: Qualitatively Identifies Proteins • Paraproteins: Heavy and light chains • Other proteins

  8. Diseases – General Medical (Non-Paraprotein Associated)

  9. Haptoglobin Alpha, -Antitrypsin Alpha, -Acid Glycoprotein C-Reactive Protein C3 Ceruloplasmin Albumin Transferrin Prealbumin Acute Phase Reactants

  10. Selective Deficiencies Must Do Quantitative Assays

  11. Diseases:Paraprotein Associated

  12. MGUS

  13. Multiple Myeloma

  14. Multiple Myeloma > 2 g/dL spike (or 3 g/dL) < Normal Immunoglobulins 5-10% or > Marrow plasma cells Bone lesions Anemia Other

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