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Grand Challenges in Organismal Biology, from the perspectives of the ASCB and Science magazine

Grand Challenges in Organismal Biology, from the perspectives of the ASCB and Science magazine. SICB, Seattle January 6, 2010 Bruce Alberts, University of California, San Francisco (UCSF) Past-president, American Society of Cell Biology Editor-in-Chief, Science magazine. Talk outline.

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Grand Challenges in Organismal Biology, from the perspectives of the ASCB and Science magazine

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  1. Grand Challenges in Organismal Biology, from the perspectives of the ASCB and Science magazine SICB, Seattle January 6, 2010 Bruce Alberts, University of California, San Francisco (UCSF) Past-president, American Society of Cell Biology Editor-in-Chief, Science magazine

  2. Talk outline • A scientific challenge from a cell biology point of view. How to stimulate more innovative research? • Two education opportunities from the ASCB. • An education opportunity from Science magazine.

  3. Science 193: 969-981 (1976) Review of a literature mostly lost in an age of electronic documents

  4. Intercalation of cells to create correct local neighbors restores normal cockroach leg

  5. Intercalation of cells to produce correct local neighbors creates grossly abnormal leg

  6. One gets opposite type of result when there are too many cells in a precursor to an embryonic structure Example in early Drosophila development when there is a 6X dose of Bicoid in the egg: huge head precursor yields normal structures in the end, due to an excess of cell death

  7. Conclusion Cells have mechanisms that allow them to sense their neighbors and to either proliferate or die until the correct two-dimensional pattern of neighbors has been generated. This property of cells is central to the development and maintenance of multicellular organisms.

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