بسم الله الرحمن الرحيم

1. بسم الله الرحمن الرحيم

2. Food Poisoning Definition Causes FOOD POISONING Food poisoning is acute illness that is caused by food ingestion. Food itself Agricultural Chemicals By Food additives Bacterial Chemicals Parasitic Dr. Doaa Abdel Wahab Lecturer of Forensic Medicine & Clinical Toxicology Mycotoxic

3. Food Poisoning Botulism Types: Definition Incubation period • Clostridium botulinium is spore-forming, anaerobic, gram positive bacillus. • The spores contain one of eight strains of potent neurotoxin A, B, C-α, C- β, E, D,F and G. • Food borne botulism: in which toxin is formed before consumption. • Infant botulism: is produced by organism in immature GIT. • Wound botulism: due to traumatic wounds which is contaminated from soil. Is a disease caused by botulinum toxin, which produces life threatening muscle paralysis. I. P. in food borne botulism is18 – 36 hs. I. P. in wound botulism is4 – 14 days. Mechanism of action

4. Food Poisoning Botulism Prevention Treatment Investigations C / P A) Food borne botulism B) Infant botulism C) Wound botulism • Acidification to pH < 4.5. 2) Heat to destroy the toxin and spores to 100 0C for 10 min or for 60 0C for 30 min. 3) Refrigeration. 4) When opening a canned preparation, do not taste if there is any suspicion of spoilage. Supportive • - Cranial nerve affection (6 & 3). • - Cardiac arrest. • - Dry mouth, difficulty in swallowing, bulbar muscle weakness • - Descending symmetrical paralysis. • Deep tendon reflexes are diminished. • GIT symptoms. • Resp. m weakness. • - Respiratory failure & death. Similar to food borne botulismEXCEPT for lack of GIT symptoms. It commonly occurs in patients with surgical wounds after IP 4 – 14 days. • Constipation. • Difficult feeding. • Decrease gag reflex. • Persistent hypotonia. • Tachycardia. 1- Serum analysis. 2- Stool analysis. 3- Vomitus. 4- Gastric content. 5- Wound. 6- Suspectd food. Decontamination Neutralization Human botulism IG Symptomatic