Multiple Interventions for Multiple Targets. Emilia Bagiella, PhD Columbia University. Traumatic Brain Injury (TBI). An injury to the head arising from blunt or penetrating trauma or from acceleration-deceleration forces Damage can be focal or diffuse Closed head injury
Emilia Bagiella, PhD
Initial acute insult (diffuse axonal injury) followed by a cascade of events involving multiple secondary injuries
Physiological - Surgical
Let Yi = 1(0) denote the success(failure) for the
i th measure (i =1, … ,k)
Let T = 1(0) for experimental(standard) Tx.
b1 = b2 = … = bk = b
Statistical power is greatest when the odds ratios are all equal, but that is nor required to test H0: all bi = 0 (no treatment effect with any measure)
But that is an ambiguous situation where careful judgment is required, in which case reduced power may not be inappropriate
The methods can be easily extended to clinical trials with stratified randomization.