Multiple Interventions for Multiple Targets. Emilia Bagiella, PhD Columbia University. Traumatic Brain Injury (TBI). An injury to the head arising from blunt or penetrating trauma or from acceleration-deceleration forces Damage can be focal or diffuse Closed head injury
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Emilia Bagiella, PhD
Initial acute insult (diffuse axonal injury) followed by a cascade of events involving multiple secondary injuries
Physiological - Surgical
Let Yi = 1(0) denote the success(failure) for the
i th measure (i =1, … ,k)
Let T = 1(0) for experimental(standard) Tx.
b1 = b2 = … = bk = b
Power is reduced if some bi = 0 or are of opposite signs.
But that is an ambiguous situation where careful judgment is required, in which case reduced power may not be inappropriate