Introduction to Human Aging
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Introduction to Human Aging. A. Methods used to study aging. longitudinal studies of humans cross-sectional studies of humans lower animal studies. known genetic make-up controlled environment short life spans. Introduction to Human Aging. B. Number and percentage of the elderly.

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Introduction to human aging

Introduction to Human Aging

A. Methods used to study aging

longitudinal studies of humans

cross-sectional studies of humans

lower animal studies

known genetic make-up

controlled environment

short life spans


Introduction to human aging

Introduction to Human Aging

B. Number and percentage of the elderly

  • In the US, more persons > 65 than < 25 years of age

  • 2. Median age was ~32 in 1995; was 36 in 2000, and will be ~42 by 2040

yearpop.number > 65% of elderly

190075.6 mil3.1 mil 4.1

1940132.3 mil9.0 mil 6.8

1960181.0 mil16.6 mil 9.2

1980228.0 mil25.6 mil 11.2

1990250.0 mil31.2 mil 12.5

2000 268.5 mil34.9 mil 13.0

2030 304.7 mil64.6 mil 21.2


Introduction to human aging

Introduction to Human Aging

C. Percentages of the elderly


Introduction to human aging

Introduction to Human Aging

D. Problems for younger members of society

30% of health care resources used by persons >65 years (will increase to 50% by 2030)

2. Older persons require more social services and specialized recreational facilities; these require money (increased taxes)

3. The burden of support falls now and will fall more heavily on the younger generations.


Introduction to human aging

Introduction to Human Aging

E. General effects of aging

  • 1. Aging is a continuing, normal process.

  • 2. Begins at maturity, ends with death

  • 3. Effects of aging increase at age 40

  • Aging is influenced by interactions of genetics

  • and environmental factors.


Introduction to human aging

Introduction to Human Aging

F. Estimated declines in some functions with age

(age 30 = 100%)

% at age 60% at age 80

nerve conduction velocity9688

basal metabolic rate9684

cardiac index8270

kidney function96 61

renal plasma flow8951

vital capacity8058

maximal breathing capacity8042


Introduction to human aging

Introduction to Human Aging

G. What is homeostasis?

1. based on two Greek roots

“homoi” = same

“stasis” = standing still

  • 2. Homeostasis is the sum of all bodily processes, maintaining constancy within limits.

  • In the absence of homeostasis, dysfunction of the organ systems is more likely, and aging increases the likelihood of death.


Introduction to human aging

high

function

steady state

low

time

Introduction to Human Aging

H. What is a feedback system?

  • 1. Negative feedback

  • 2. Positive feedback


Introduction to human aging

Introduction to Human Aging

I. Common terms related to aging

  • Aging

  • Senescence

  • Senility

  • Elderly vs. old vs. very old

  • Gerontology

  • Geriatrics

  • Longevity (mean vs. maximum)

  • Demography


Introduction to human aging

Introduction to Human Aging

J. General aging changes in the body

  • Body structural changes

  • a. gradual decline in height beginning in the late 30’s

  • shortening of lower limbs due to decreasing joint size and feet arches

  • shortening of trunk due to increase in normal vertebral column curvature and compression of discs

  • b. gradual deterioration of muscle, causing shoulder width to decrease

  • c. increased fat deposition in abdomen, hips increase in width


Introduction to human aging

Introduction to Human Aging

J. General aging changes in the body

  • Body structural changes

  • loss of lung elasticity, leading to increased respiratory effort and increased thoracic circumference

  • e. changes in body weight

  • i. men increase weight until mid-50’s, then lose

  • ii. women gain weight into the 60’s, then lose


Introduction to human aging

Introduction to Human Aging

J. General aging changes in the body

  • 2.Body compositional changes

  • total body water

  • young man -- average water = 60% of body weight; drops to 54% with aging

  • ii.young woman -- average water = 52% of body weight; drops to 46%

  • b.changes in skin thickness

  • in general there is a gradual but steady decline in skin thickness

  • ii.extra adipose tissue accumulates around organs rather than in hypodermis


Introduction to human aging

Introduction to Human Aging

J. General aging changes in the body

  • 3.Body functional changes

  • Most noticeable changes

  • movement becomes more difficult

  • breathing becomes more difficult

  • elevated blood pressure

  • changes in dietary habits

  • changes in urinary frequency and bowel movementsC

  • b.Functional changes dependent on genetic make-up, lifestyle history, and environment


Introduction to human aging

Introduction to Human Aging

K. Importance of regular health exams

  • 3.Body functional changes

  • Generally accepted standard intervals

  • Baseline info for the MD as patient ages

  • Early detection of problems

  • Examples

  • physicals = >70 annualy; 60-70 biannual; 40-60 triannual; 20-40 every 5 years

  • blood pressure and Pap smear = yearly

  • cholesterol = every 5 years

  • proctosigmoidoscopy = every 3 years at 40; yearly at 50

end


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