1 / 14

BIOINFOGRID: Bioinformatics Grid Application for life science

BIOINFOGRID: Bioinformatics Grid Application for life science. MILANESI, Luciano National Research Council Institute of Biomedical Technologies) luciano.milanesi@itb.cnr.it. Project descriptions. Bioinformatics Grid Application for life science (BIOINFOGRID) project.

carol-york
Download Presentation

BIOINFOGRID: Bioinformatics Grid Application for life science

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript


  1. BIOINFOGRID: Bioinformatics Grid Application for life science MILANESI, Luciano National Research Council Institute of Biomedical Technologies) luciano.milanesi@itb.cnr.it

  2. Project descriptions • Bioinformatics Grid Application for life science (BIOINFOGRID) project. • The BIOINFOGRID projects proposes to combine the Bioinformatics services and applications for molecular biology users with the Grid Infrastructure created by EGEE. • In the BIOINFOGRID initiative we plan to evaluate genomics, transcriptomics, proteomics and molecular dynamics applications studies based on GRID technology. • BIOINFOGRID will evaluate the Grid usability in wide variety of applications, and explore and exploit common solutions. EGEE User Forum 01-03 March 2006, Geneve

  3. HTS High Throughput Data Project Microsatellite MSMS EST DNA High Throughput Sequencing Microarray SNP’s EGEE User Forum 01-03 March 2006, Geneve

  4. Introduction • A typical gene lab can produce 100 terabytes of information a year, the equivalent of 1 million encyclopedias. • Few biologists have the computational skills needed to fully explore such an astonishing amount of data; nor do they have the skills to explore the exploding amount of data being generated from clinical trials. • The immense amount of data that are available, and the knowledge is the tip of the data iceberg. Bioinformatics: Emerging Opportunities and Emerging Gaps1 Paula E.Stephan and Grant Black EGEE User Forum 01-03 March 2006, Geneve

  5. The grid application aspects. • The massive potential of Grid technology will be indispensable when dealing with both the complexity of models and the enormous quantity of data, for example, in searching the human genome or when carry out simulations of molecular dynamics for the study of new drugs. • The BIOINFOGRID projects proposes to combine the Bioinformatics services and applications for molecular biology users with the Grid Infrastructure created by EGEE Enabling Grids for E-sciencE EGEE User Forum 01-03 March 2006, Geneve

  6. Data Integration Proteins (Proteomics) Microarray (Trascriptomics) Gene & SNPs (Genomics) EGEE User Forum 01-03 March 2006, Geneve

  7. Applications in GRID Genomics Applications in GRID • Analysis of the W3H task system for GRID. • GRID analysis of cDNA data. • GRID analysis of the NCBI and Ensembl databases. • GRID analysis of rule-based multiple alignments. Proteomics Applications in GRID • Pipeline analysis for protein functional domain analysis. • Surface proteins analysis in GRID platform. Transcriptomics and Phylogenetics Applications in GRID • Data analysis specific for microarray and allow the GRID user to store and search this information, with direct access to the data files stored on Data Storage element on GRID servers EGEE User Forum 01-03 March 2006, Geneve

  8. Applications in GRID Database and Functional Genomics Applications • to manage and access biological database by GRID • to cluster gene products by their functionality as an alternative to the normally used comparison by sequence similarity. Molecular Dynamics Applications • to improve the scalability of Molecular Dynamics simulations. • to perform simulation folding and aggregation of peptides and small proteins, to investigate structural properties of proteins and protein-DNA complexes and to study the effect of mutations in proteins of biomedical interest. • to perform a challenge of the Wide In Silico Docking On Malaria. EGEE User Forum 01-03 March 2006, Geneve

  9. ID MURA_BACSU STANDARD; PRT; 429 AA. DE PROBABLE UDP-N-ACETYLGLUCOSAMINE 1-CARBOXYVINYLTRANSFERASE DE (EC 2.5.1.7) (ENOYLPYRUVATE TRANSFERASE) (UDP-N-ACETYLGLUCOSAMINE DE ENOLPYRUVYL TRANSFERASE) (EPT). Genetics applications in GRID EGEE User Forum 01-03 March 2006, Geneve

  10. Farm2 • Temporal distribution of a working database SE Data flow for local database creation RB Normal grid job data flow UI Database Applications EGEE User Forum 01-03 March 2006, Geneve

  11. Transcriptomics & Phylogenetics Data analysis specific for microarray and allow the GRID user to store and search this information, with direct access to the data files stored on Data Storage element on GRID servers and to discovery new cluster motifs Gene expression Candidate Motifs EGEE User Forum 01-03 March 2006, Geneve

  12. Bioinformatics Data challenge EGEE User Forum 01-03 March 2006, Geneve

  13. http://www.itb.cnr.it/bioinfogrid EGEE User Forum 01-03 March 2006, Geneve

  14. CREDITS • Suhai Sándor (DKFZ) Germany • Mazzucato, Mirco (INFN), Italy • Breton Vincent (CNRS/IN2P3), France. • Giorgio Maggi (INFN), Italy • Legre Yannick (CNRS/IN2P3), France. • Francesco Beltrame (DIST), Italy • Lio’ Pietro (UNIVERSITY OF CAMBRIDGE), UK • Meloni Giovanni (CILEA), Italy • Giselle Andreas (CNR-ITB), Italy • Ivan Merelli (CNR-ITB), Italy EGEE User Forum 01-03 March 2006, Geneve

More Related