High intensity focused ultrasound therapy array
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High-Intensity Focused Ultrasound Therapy Array. May1005 Alex Apel Stephen Rashid Justin Robinson. Problem / Need Statement. Problem Traditional Tumor Removal: Invasive HIFU: Non-Invasive Tumor Removal Need Research tool to Control HIFU Therapy Array Independent Control of Transducers.

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High-Intensity Focused Ultrasound Therapy Array

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High intensity focused ultrasound therapy array

High-Intensity Focused Ultrasound Therapy Array

May1005

Alex Apel

Stephen Rashid

Justin Robinson


Problem need statement

Problem / Need Statement

  • Problem

    • Traditional Tumor Removal: Invasive

    • HIFU: Non-Invasive Tumor Removal

  • Need

    • Research tool to Control HIFU Therapy Array

    • Independent Control of Transducers


Requirements wishes

Requirements & Wishes

  • Requirements

    • Generate Independent Waveform

      • 1.1 MHz

      • 500W Instantaneous Power

      • 0.01% - 1% Duty Cycle

  • Wishes

    • Collect Feedback Data

      • 50 M Samples / Sec

      • Provide Feedback Access

    • User Interface

      • Clean Interface to System

      • Specify waveform properties

        • Pulse Duty Cycle

        • Pulse Period

        • Pulse Count

      • Relative Phase


System architecture

System Architecture


Risks

Risks

  • Loss of Team Member

  • Damage to Equipment

  • Lack of Expertise

  • Time Constraints

  • Budget Constraints


Software architecture

Software Architecture

RS-232

Micro

GUI

  • Input

  • Generate Waveform

  • Process Feedback

  • Input

  • Relative Transducer Phase

  • Transducer Amplitude

  • Signal Period

  • Signal Duty Cycle

  • Start/Stop Generation

  • Output

  • Phase

Control Logic

Transducer

Feedback

Analog Hardware

Transducer

Transducer

Transducer


Software prototype architecture

Software Prototype Architecture

Micro

  • PWM

  • Two Channel Control

  • Hard Coded Waveform

Control Logic

Analog Hardware

Transducer

Transducer

Transducer


Software implementation

Software Implementation

  • User Interface

    • Serial Communication with MCU

    • Graphical Input

  • Microcontroller

    • Prototype Implementation

      • PWM: Direct Control

    • Final Implementation

      • PreliminarySerial Communication


Software testing evaluation

Software Testing & Evaluation

  • PC Software

    • Unit Testing of Serial Communication

    • Further Testing: On Hold

  • Microcontroller Software

    • Prototype Software


Next steps

Next Steps

  • Two-way Communication: MCU PC Software

  • Fabrication of PCB

    • Writing Waveforms to RAM

    • Reading Feedback from RAM


Digital architecture

Digital Architecture

MCU

Feedback RAM

Waveform RAM

Feedback RAM

Waveform RAM

ADC

Analog Circuitry

ADC

Analog Circuitry


Digital implementation

Digital Implementation

  • Microcontroller

    • Acquisition Complete

    • Writing software

    • Paused for PCB Layout

  • Logic Circuitry

    • IC Acquisition Complete

    • Logical Layout Complete

    • PCB Layout Complete

    • PCB Routing in Progress

  • Prototype Software

    • Fully Implemented

    • Capable of bypassing Logic Circuitry

    • Critical for system prototype


Digital testing evaluation

Digital Testing & Evaluation

  • Testing

    • Microcontroller

      • Test Code

      • Controls Waveform Directly

    • Logic Circuitry

      • Not Implemented

    • Prototype Software

      • Range of desired Waveforms

  • Evaluation

    • Microcontroller

      • System in place

      • Executes

    • Logic Circuitry

      • System ready for assembly

      • System easily modified

      • Bypassed

    • Prototype Software

      • Asserts Logic Circuitry Waveform


Next steps1

Next Steps

  • Microcontroller

    • Complete Software

    • Use ribbon cable to physically connect to PCB

  • Logic Circuitry

    • Assemble the ordered PCB

    • Write and execute waveforms

    • Read back feedback data

    • Remove role of prototype code


Analog implementation

Analog Implementation

  • H-Bridge

  • Half-Bridge

  • HIP4081A controller


Analog architecture

Analog Architecture

Half Bridge A

Transducer

From Micro

Half-Bridge Controller

High Voltage DC

Power Supply

Transducer

Half Bridge B


Analog testing evaluation

Analog Testing & Evaluation

  • Emulation testing

    • Problems

    • Potential

  • Low power transducer

  • High power transducer


Next steps2

Next Steps

  • Further evaluation of half-bridge amplifier

  • Integration with logic circuitry

  • Expansion to more channels

  • Test with Transducer


Lessons learned

Lessons Learned

  • Prioritize System Features from Beginning

  • Controlling System Scope is Important

  • Order Extra Parts

  • Hardware Takes a Long Time to Realize

  • Knowing Your Tools is Key to Development Time

  • Benefit from Others Experience


Acknowledgments

Acknowledgments

Dr. Timothy Bigelow

Dr. Randy Geiger

Texas Instruments


Questions

Questions?


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