Cancer basics
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Term cancer derives from observation by Hippocrates Cancer is a group of diseases All involve uncontrolled division of the body’s cells. Cancer Basics. Tumors originate from a single cell Mutation that occurs usually in 1 of 2 types of genes: proto-oncogenes or tumor-suppressor genes.

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Cancer Basics

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Cancer basics

  • Term cancer derives from observation by Hippocrates

  • Cancer is a group of diseases

  • All involve uncontrolled division of the body’s cells

Cancer Basics


Cancer basics1

  • Tumors originate from a single cell

  • Mutation that occurs usually in 1 of 2 types of genes: proto-oncogenes or tumor-suppressor genes

Cancer Basics


The body s natural defenses

  • DNA proofreading and repair

The Body’s Natural Defenses


The body s natural defenses1

  • DNA code redundancy

The Body’s Natural Defenses


Cancer basics

The Body’s Natural Defenses

Fig. 12-19

Anchorage dependence

Density-dependent inhibition

Density-dependent inhibition

25 µm

25 µm

(a) Normal mammalian cells

(b) Cancer cells


The body s natural defenses2

  • Cell suicide (apoptosis)

The Body’s Natural Defenses


The body s natural defenses3

  • Cell suicide (apoptosis)

The Body’s Natural Defenses


Cancer is a multistep process

  • Tumors originate from one cell, but as a tumor develops the cells within it can start to change / evolve becoming increasingly unstable!

Cancer is a Multistep Process!


Cancer basics

RADIOLAB!

Famous Tumors 4:25min

  • 1. How is cancer a multistep process? What are some of the “steps” involved?

  • 2. How does evolution / natural selection relate to cancer?

  • 3. Can cancer be contagious?


Cancer is a multistep process1

  • Increased incidence with age

  • Increased incidence with exposure to environmental carcinogen or inherited mutation

  • Lag time between exposure and cancer development

Cancer is a Multistep Process!


Cancer s toll

  • 2nd leading cause of death in the U.S.

  • Men have a 1 in 2 lifetime risk of developing cancer; and women have a 1 in 3 risk

  • Only about 25% of all cancers are “hard core”

Cancer’s Toll


New treatments

  • Immune-mediated tumor destruction

  • http://www.nytimes.com/2011/09/13/health/13gene.html?pagewanted=all

New Treatments?


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