Modeling oscillating neurons in respiratory rhythmogenesis
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Modeling Oscillating Neurons in Respiratory Rhythmogenesis. Connie Oh. preBotzinger Complex: site of rhythm generation. Looking for inspiration: new perspectives on respiratory rhythm Jack L. Feldman and Christopher A. Del Negro Nature Reviews Neuroscience 7, 232-241 (March 2006).

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Modeling Oscillating Neurons in Respiratory Rhythmogenesis

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Modeling oscillating neurons in respiratory rhythmogenesis

Modeling Oscillating Neurons in Respiratory Rhythmogenesis

Connie Oh


Prebotzinger complex site of rhythm generation

preBotzinger Complex:site of rhythm generation

Looking for inspiration: new perspectives on respiratory rhythm

Jack L. Feldman and Christopher A. Del Negro

Nature Reviews Neuroscience 7, 232-241 (March 2006)


Hodgkin huxley 1952

Hodgkin-Huxley (1952)

V’ = (- 1/c) * [ iapp + gNa*m3h*(V – ECa) +

gK*n4*(V – EK) + gleak*(V – Eleak) ]

m’ = αm(V)(1 – m) - βm(V)(m)

h’ = αh(V)(1 – h) - βh(V)(h)

n’ = αn(V)(1 – n) - βn(V)(n)


Fitzhugh nagumo 1962

Fitzhugh-Nagumo (1962)

є v’ = v*(v – a)(1 – v) – w

w’ = v – b*w – c


Morris lecar 1981

Morris-Lecar (1981)

V’ = (-1/c) * [ iapp + gleak*(V – Eleak)

+ gK*w*(V - EK) + gCa*m∞(V)*(V – ECa) ]

w’ = φ * [w∞(V) – w] / τw(V)


Novel model

Novel Model

V’ = - (1/c) * [ iapp + gleak*(V – Eleak)

+ gNa*(V – ECa) + gK*(V – EK)

+ gCa*(V – ECa) + gsyn*(V – Esyn)

+ gton*(V – Eton) + gCa*f(Ca)*(V – ECa) ]


Modeling oscillating neurons in respiratory rhythmogenesis

ca0.50.40.30.20.10-0.1-0.2V0-10-20-30-40-50-60


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