Rhabdoviruses HUMAN RABIES. Professor Sudheer Kher. DEFINITION. Rabies is an acute, progressive encephalomyelitis The case to fatality rate is the highest of any infectious disease One of the oldest described diseases The leading viral zoonosis as regards global public health significance.
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Professor Sudheer Kher
Murray et al., Medical Microbiology
Starts in the same way, but instead of progressing into excitement, the subject retreats steadily and quietly downhill, with someparalysis, to death. Rabies diagnosis may easily be missed.
1.Bite - Geographical area, type of animal, severity and site of bite.
Live - observe in cage:
If survives > 8 days, then NOT rabies.
Dead - brain sent to Ref Virology Lab
- Negri bodies
Live - difficult diagnosis
- clinical picture, skin biopsy, corneal impression (antibodies only appear very late)
Dead - brain sent to Virology Lab
"Negri bodies" in cytoplasm of brain cells;
immunofluorescence virus isolationDIAGNOSIS
Rabies virus infected
Rabies virus infected - Negri body - note dark blue basophilic granules (Seller’s stain)
A small bat bite on a finger