Development of the heart. Dr Rania Gabr. oBJECTIVES. Describe the formation and position of the heart tube. Explain the mechanism of formation of the cardiac loop. Discuss the development of sinus venosus . Explain how cardiac septa are formed.
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Development of the heart
Dr Rania Gabr
Formation of the Cardiogenic field
Clusters of angiogenetic cells form a "horseshoe-shaped" cluster anterior and lateral to the brain plate.
- The clusters form endothelial vessels which fuse to form the right and left endocardial heart tubes
- As a result of folding of embryo in transverse direction the two endocardial heart tubes come close to each other and fuse to form single endocardial tube
Mesoderm of the cardiogenic plate at the 3rd week.
3- common cardinal veins.
Lateral folding results in fusion of the caudal portion of the paired endocardial tubes
1st aortic arch
Chambers of the heart tube:
The heart tube continues to grow and bend, atrium shifts in the dorso-cranial direction; sinus venoususlocated at caudal portion of atrium.