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Text Mining in Animal Health Surveillance. John Berezowski Clarissa Snyder Lindsay Mclarty Food Safety Division Alberta Agriculture Food And Rural Development. Text Mining In Public Health. Knowledge management Classification of journal articles to manage and search of databases

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text mining in animal health surveillance

Text Mining in Animal Health Surveillance

John Berezowski

Clarissa Snyder

Lindsay Mclarty

Food Safety Division

Alberta Agriculture Food And Rural Development

text mining in public health
Text Mining In Public Health
  • Knowledge management
    • Classification of journal articles to manage and search of databases
    • Classification of hospital records to allow data mining of hospital databases to discover knowledge
  • Classification of medical records for real time surveillance
    • Free text emergency room chief complaints classified into syndromes eg GI or Influenza like
purpose
Purpose
  • Canada-Alberta BSE Surveillance Program:
    • CABSESP
    • Alberta Veterinarians participate in BSE surveillance
    • Submit cattle samples for BSE testing
      • Dead or euthanized
    • Examine cattle prior to sampling
    • Provide data about farmers and animals tested
  • Purpose: maximize information about cattle tested
    • Especially why cattle were: sick/dead/sampled
    • Assist CFIA to identify ‘Clinical Suspects”
purpose1
Purpose
  • Large sample (July 04 - July 06)
    • 35,720 Alberta cattle tested by AAFRD
      • Another 25,000(+/-) tested by the CFIA
    • 9,117 farms
    • 141 veterinary clinics (293 veterinarians)
  • Purpose: evaluate utility of BSE submission form data for other surveillance purposes
submission form data
Submission Form Data
  • Farmer ID, date, location, number on farm
  • Purebred (y/n), breed, age, sex, BCS, PM (y/n)
  • Diseased, Distressed, Down, Dead, Neuro
  • Clinical signs in free text format
  • Presumptive diagnosis in free text format
example submission
Example Submission
  • Clinical Signs: Cow was in dry lot. Went off feed, coughing and labored breathing
  • Presumptive Diagnosis: PM findings- traumatic pericarditis and abscess from hardware between reticulum and diaphragm
  • Need tools (Text Mining) to extract information from free text fields
text mining definition
Text Mining: Definition
  • Based on data mining definitions
  • Knowledge discovery in text
  • Semi or automated discovery of trends and patterns across large volumes of text
  • Computer applications that aim to aid in making sense of large volumes of text
text mining our context
Text Mining: Our Context
  • Classify cattle with respect to certain concepts:
    • Etiologies: Johne’s, AIP, hepatic lipidosis, LDA, IBR, unknown, etc.
    • Descriptors: acute, chronic, emaciated, lame, autolyzed, blind, ataxic, etc.
    • Clinical Presentation:Syndromes: respiratory, GI, repro etc
  • Use classifications to better describe the cattle sampled and look for associations or trends within the samples
named entity recognition
Named Entity Recognition
  • Identify terms in text

-Term = textual representation of a concept

  • Classify terms

-Noun vs verb vs adjective,preposition, etc.

-Etiology vs descriptors: animal (pregnant) vs clinical sign (chronic)

  • Map terms to concepts in an ontology

-Associate each term with one or more concepts

Bleeding

Concept of hemorrhage

Bled

Hemorrhage

problems with our data
Problems With Our Data
  • No suitable ontology
  • What’s an ontology?
    • A model that links concept labels to their textual representations and defines or describes the relationships between concepts
    • Machine readable descriptions of concepts and their relationships
    • Examples: Dictionaries, SNOMED-SNOVET
problems with our data1
Problems With Our Data
  • Terms are formal (vet/med) + unusual

“Nephritis”, “peritonitis”, “cancer eye”, “lump jaw”, “corkscrew claw”, ‘downer”, “fatty liver”, “hardware”, “found dead”

  • Specific to food animal practitioners.
problems with our data2
Problems With Our Data
  • Term Variation
    • A single concept is expressed in a number of different ways (synonyms)
    • Probability of two experts using the same term to refer to the same concept is lessthan 20%1
    • Arthritis: arthritis, arthritic, osteoarthritis, polyarthritis, septic-arthritis
  • 1Grefenstette G. 1994
problems with our data3
Problems With Our Data
  • Term Ambiguity
    • The same term is used to refer to multiple concepts
    • Multiple meanings for the same term
    • Boated= nutritional (feedlot, pasture), or bloated abdomen (perforated ulcer)
    • Prolapse = vagina, uterus, rectum, vaginal fat, intestinal
problems with our data4
Problems With Our Data
  • No sentence structure
    • “Old age, arthritis, no teeth”
    • “Stifle, bilateral, degenerative, arthritis”
    • ‘Pelvic injury, post calving, crippled “
    • “Down, tumor on R shoulder, losing condition”
build our ontology
Build Our Ontology
  • From the text fields on the submission forms
  • Designed to meet our classification needs
    • Identify Potential “Clinical Suspects”
    • Classify BSE submissions into clinical syndromes
clinical suspect
Clinical Suspect

Refractory To Treatment

Alive

Yes

Yes

Progressive Behavior Change

Progressive Neuro Signs

OR

Clinical Suspect

Yes

Over 30 Months

Rule Outs

No

Yes

[Alive]AND[(Refractory to tx)AND(Progressive Behavior ChangeORProgressive Neuro Change)AND(No Rules Outs)AND(Over 30 months of Age)]

Clinical Suspect=

clinical suspect1
Clinical Suspect

Refractory To Treatment

Alive

Yes

Yes

Progressive Behavior Change

Progressive Neuro Signs

OR

Clinical Suspect

Yes

Over 30 Months

Rule Outs

No

Yes

[Alive]AND[(Refractory to tx)AND(Progressive Behavior ChangeORProgressive Neuro Change)AND(No Rules Outs)AND(Over 30 months of Age)]

Clinical Suspect=

ontology
Ontology
  • Chronic (refractory to Tx)
  • Neurologic
  • Behavioral
  • Rule outs
    • Lame Skin/Ocular/Mammary
    • Cardiovascular Sudden Death
    • GI Infectious Dz
    • Repro Edema/Swelling/Neoplasia
    • Respiratory Trauma
    • Urologic Anorexia/Wt loss
method
Method
  • Text Mining Software
    • “WordStat” and “SimStat” (Provalis Research, Quebec City, PQ)
  • Spell checked text fields
  • Identified all words in the text fields
    • 292,537 words in total, 7,266 unique
  • Manually sorted words into ontology categories
chronic
Chronic
  • ADVANCED DOWNHIL*
  • CHONIC DURATION
  • CHRINIC AWHILE
  • CHRONCI POOR_DOER
  • CRONIC DECLIN*
  • D*BILIT* EMACIAT*
  • DAYS_AGO
neurological
Neurological
  • Ataxia
  • Neurological
  • Paresis/Paralysis
  • Hyperesthesia
  • Hypermetria
  • Locomotor deficits
neurological1
Neurological
  • Ataxia
    • *ATAX*, AT*XIA, AT*XIC, ATACHIA, ATAXIA, TAXIA, etc
  • CNS
    • CN*, MENINGITIS, MENINGOMA , etc
  • Neurological
    • CONVULS*, HEAD_PRESS*, HEPATOENCEPHALOPATHY, N*URO*, NEUR*, etc
  • Paresis/Paralysis
    • PARLAYSIS, PARLYSIS, PARYALYZED, PARAPARESIS, PAREISIS, PARES*, PARETIC, etc
behavioral
Behavioral
  • Behavioral
  • Hyperexcitable
behavioral1
Behavioral
  • Behavioral
    • *EHAV*, APPREHENS*, AVOID*, BALKING, BAWLING, BELIGER*, BELLIGER, BELLOW*, BIZARRE, COMPULSIVELY, CRAZY, DELIROUS etc
  • Hyperexcitable
    • ANXIETY, ANXIOUS, CHARG*, CHASE*, EXCITEABLE, HYPERALERT, HYPEREXC*, HYPEREXCITABLE, HYPERSENSITIV*, IRRITA*, etc.
example submission1
Example Submission
  • Clinical Signs: Cow was in dry lot. Went off feed, coughing and labored breathing
  • Presumptive Diagnosis: PM findings- traumatic pericarditis and abscess from hardware between reticulum and diaphragm
classifying submissions
Classifying Submissions
  • Cow was in dry lot. Went off feed, coughing and labored breathing

Anorexia

Respiratory

classifying submissions1
Classifying Submissions
  • PM findings- traumatic pericarditis and abscess from hardware between reticulum and diaphragm

GI

Cardiovascular

Trauma

veterinary practice surveillance
Veterinary Practice Surveillance
  • Veterinary Practice Surveillance (VPS)
    • Cattle practitioners submit data about about cattle to AAFRD daily via a restricted access website
    • Practitioners classify sick cattle by commodity (cow-calf, dairy etc), age and syndrome (12)
  • Large sample
    • 26,016 Submissions (Aug 05 – Dec 06)
    • 5,081 farms
    • 31 veterinary clinics
submissions per day
Submissions per day

Sept 2005 to July 2006

respiratory syndrome
Respiratory Syndrome

VPS = Cattle greater than 30 months of age

clostridium hemolyticum
Clostridium hemolyticum

VPS = 75 cases, BSE = 157 cases

utility
Utility ?
  • Classifying/identifying “High Risk”
  • Generalize with caution (no prevalence)
    • Sampling bias
    • Misclassification
      • For each classification estimate:
      • Se and Sp of veterinarians
      • Se and Sp of text classifier
utility1
Utility ?
  • But:
    • Large sample
      • Disease importance or trends over time and space
      • Clostridium hemolyticum
    • Events: syndromic, unknown, emerging
      • Establish normal patterns to identify unusual events
      • Respond/investigate
      • Access for targeted surveillance
questions
Questions?
  • Our Team:
    • Clarissa Snyder
    • Lindsay McLarty
    • John Berezowski
  • Contact us:

[email protected]

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