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DNA sequencing : Read with quantum mechanics

DNA sequencing : Read with quantum mechanics. Thomas Thundat Nature Nanotechnology 5, 246 - 247 (2010). R00945002 楊偉杰. Introduction. DNA sequencing Single molecule Multiple molecules Some disadvantages for sequencing multiple molecules Expensive and time-consuming sample preparation

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DNA sequencing : Read with quantum mechanics

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  1. DNA sequencing :Read with quantum mechanics Thomas Thundat Nature Nanotechnology 5, 246 - 247 (2010) R00945002 楊偉杰

  2. Introduction • DNA sequencing • Single molecule • Multiple molecules • Some disadvantages for sequencing multiple molecules • Expensive and time-consuming sample preparation • Difficult to discover repeated sequences • A single-molecule physics-based sequencing method is introduced • Quantum sequencing

  3. Quantum sequencing(1/2) Ref : Going Solid-State,Elizabeth Pennisi, Science 4 May 2012: Vol. 336 no. 6081 p. 536

  4. Quantum sequencing(2/2) Ref : Identifying single nucleotides by tunneling current ,Tomoji Kawai et al, Nature Nanotechnology,21 May 2010

  5. Recent progress

  6. Discussion & Conclusion • Challenges • Overlapped distribution • Overlap between different nucleotides • Trade-off :time accuracy • Techniques for creating reliable and precise nanogaps • Nucleotide localization • Speed • One base at a time • Thermal noise • Quantum sequencing is • Physics-based • Label-free • Potentially obtaining sequence information at very high rate

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