65 year old female with alzheimer s disease
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65 year-old female with Alzheimer’s disease. Lananh Nguyen, M.D. Division of Neuropathology University of Pittsburgh Medical Center. An autopsy was performed. Identify the structures arrow. An autopsy was performed. Identify the structures arrow. Corpus callosum. Caudate, tail. Thalamus.

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65 year-old female with Alzheimer’s disease

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65 year-old female with Alzheimer’s disease

Lananh Nguyen, M.D.

Division of Neuropathology

University of Pittsburgh Medical Center


An autopsy was performed. Identify the structures arrow.


An autopsy was performed. Identify the structures arrow.

Corpus callosum

Caudate, tail

Thalamus

Lateral geniculate nucleus

Hippocampus


Note the atrophy in the brain with the Alzheimer’s disease.

Severe atrophy

Normal

library.med.utah.edu


What microscopic pathology is in abundance in Alzheimer’s disease (AD)?


Neuritic plaques

Neurofibrillary tangles

Amyloid plaques

What microscopic pathology is in abundance in Alzheimer’s disease (AD)?


Neuritic plaques

Neurofibrillary tangles

Amyloid plaques

What stains would you use to evaluate microscopic pathology in Alzheimer’s disease (AD) for these features?


Neuritic plaques : Bielchowsky stain

Neurofibrillary tangles: Phosphorylated tau stain

Amyloid plaques: Beta amyloid stain

What stains would you use to evaluate microscopic pathology in Alzheimer’s disease (AD) for these features?


What “body” would you expect to see in the hippocampus of a person with AD

  • Hirano bodies


Where in the hippocampus can you find these bodies?


Where in the hippocampus can you find these bodies?

  • CA1 region of the hippocampus

CA3

CA2

CA4

CA1

Dentate gyrus


What are the 4 most common genes linked to AD?

  • Amyloid precursor protein mutation (causative gene)

  • Presenilin 1 and Presenilin 2 mutations (causative gene)

  • Apolipoprotein E4 (risk gene)


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