MICR 304 Immunology & Serology. Lecture 8A Antibodies Part II Chapter 4.2- 4.5, 4.12 – 4.20, 9.14 – 9.20. Overview of Today’s Lecture. Generation of antibodies Secondary antibody modifications Effector functions of antibodies. Key Players in Immunology.
Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author.While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server.
MICR 304 Immunology & Serology
Antibodies Part II
Chapter 4.2- 4.5, 4.12 – 4.20, 9.14 – 9.20
L: Leader sequence; directs protein to cell’s secretory pathway
: Hinge region
on chromosome 22
on chromosome 2
on chromosome 14
Includes a significant number of non-functional segments (pseudogenes)
In heavy chain, V cannot be directly joined with J.
Involves heavy chain only
Involves variable region on heavy and light chain
Mutations in the framework tend to disrupt the antibody structure and are selected against.
IgM Pentamer (5mer)
Monomers are cross-linked by disulfide bridges that connect each other and J-chain
IgA Dimer (2mer)
IL4 induces IgE
IL5 augments IgA
IFNg induces IgG
TNFb induces IgG and IgA
In conjunction with complement
Antibody conformation change
Activate classical pathway of complement
Binding of C1q to the Fc piece
Pentameric IgM is more efficient
Antibody Dependent Cell Mediated Cytotoxicity