mind body lifestyle management
Download
Skip this Video
Download Presentation
Mind, Body & Lifestyle Management

Loading in 2 Seconds...

play fullscreen
1 / 61

Mind, Body & Lifestyle Management - PowerPoint PPT Presentation


  • 138 Views
  • Uploaded on

Mind, Body & Lifestyle Management. Zita West Midwife, acupuncturist, nutritionist Northern Ireland Fertility Information Day 2014 Saturday 27 th September 2014. Mind, body and lifestyle management. All body systems are interconnected Physiological, psychological

loader
I am the owner, or an agent authorized to act on behalf of the owner, of the copyrighted work described.
capcha
Download Presentation

PowerPoint Slideshow about ' Mind, Body & Lifestyle Management' - callie-adams


An Image/Link below is provided (as is) to download presentation

Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author.While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server.


- - - - - - - - - - - - - - - - - - - - - - - - - - E N D - - - - - - - - - - - - - - - - - - - - - - - - - -
Presentation Transcript
mind body lifestyle management
Mind, Body & Lifestyle Management

Zita West

Midwife, acupuncturist, nutritionist

Northern Ireland Fertility Information Day 2014

Saturday 27th September 2014

mind body and lifestyle management
Mind, body and lifestyle management
    • All body systems are interconnected
    • Physiological, psychological
    • Emotion and wellbeing are key
    • Stress reduction
    • Nutrition
  • = a holistic approach

Fertility is a whole-body event

slide3
MIND

Ancient philosophy vs

modern medicine

mind body and lifestyle management1
Mind, body and lifestyle management
  • The mind-set of a couple trying for a baby
    • Uncertainty
    • Negativity
    • Strong emotions
    • Fear
    • Anxiety
    • Worry
    • Voices of authority
    • Lack of belief
    • Lack of confidence
mind body and lifestyle management2
Mind, body and lifestyle management
  • Relationship Dynamics
  • What is stopping this couple from conceiving?
mind body and lifestyle management3
Mind, body and lifestyle management
  • The Past, the Present, the Future
  • Every couple we see:
    • What is stopping the couple from conceiving?
    • What is the dynamic of the relationship?
    • Is there anything else that may be stopping you two from getting pregnant?
mind body and lifestyle management4
Mind, body and lifestyle management
  • Stress
    • Depression
    • Natural
    • IVF

C.D. Lynch, R. Sundaram, J.M. Maisog, A.M. Sweeney, G.M. Buck Louis: Preconception stress increases the risk of infertility: results from a couple-based prospective cohort study—the LIFE study Hum. Reprod. deu032 first published online March 23, 2014 doi:10.1093/humrep/deu032

mind body and lifestyle management5
Mind, body and lifestyle management
  • Our clients
    • Highly anxious
    • Stressed
    • Exhausted
    • Emotional
    • Physical aspects of stress
      • Raised cortisol levels
      • Reduced blood flow
      • Hormonal imbalances

C.D. Lynch, R. Sundaram, J.M. Maisog, A.M. Sweeney, G.M. Buck Louis: Preconception stress increases the risk of infertility: results from a couple-based prospective cohort study—the LIFE study Hum. Reprod. deu032 first published online March 23, 2014 doi:10.1093/humrep/deu032

mind body and lifestyle management6
Mind, body and lifestyle management
  • Hypnotherapy and Visualisation, Stress reduction
  • 5% conscious mind
  • 95% subconscious
mind body and lifestyle management7
Mind, body and lifestyle management
  • Writing / drawing
  • Counselling
  • Hypnotherapy
  • Acupuncture
  • CBT
  • Breathing
  • Visualisation
  • Stress management
  • Hypnotherapy and Visualisation, Stress reduction
mind body and lifestyle management8
Mind, body and lifestyle management
  • The bedroom is a battleground
pressures
Pressures

sex, work, life

mind body and lifestyle management9
Mind, body and lifestyle management
  • Woman
    • Computer/stick/app/phone says ovulation
    • He\'d better be home on time
    • Pacing the floor
    • Tension rising
    • MY EGG WILL ONLY LAST 24 HOURS
    • Then we’ll have to wait another month!
    • If he’s late and we miss this window, there\'s no sex for him for the rest of the month
    • God, I hope it happens this month
    • I hate being so desperate
    • I wish sex wasn’t becoming so mechanical
  • Man
    • I wish she wouldn’t do temperatures, internet and gadgets: it makes her more obsessive
    • Such a busy day today: I don’t know how I\'m going to leave at 6.00
    • I\'m going to get such grief if I\'m late tonight
    • The anxiety is starting: I might not be able to perform
    • I wish I could fix it for her
    • I feel helpless and don’t know how to support her when it hasn’t happened
    • I hate seeing her so unhappy
    • I wish sex wasn’t so mechanical
mind body and lifestyle management10
Mind, body and lifestyle management
  • Time to pregnancy
      • 84% couples who have regular sex without contraception will conceive in one year.
      • Of those who fail to conceive in first year, about half will conceive in second year. Cumulative pregnancy rate: 92% at 2 years.1
  • For the majority of couples it takes only two things:

1. Time.

2. Opportunities for sex

  • 1. NICE, Fertility assessment & treatment for people with fertility problems, Clinic Guideline 11, 2004
mind body and lifestyle management11
Mind, body and lifestyle management
  • Common myths
    • Myths around ovulation
    • Timing of sex
    • How long an egg lasts
    • How long a sperm lasts
    • Saving up the sperm
    • Positions for sex
    • What happens after sex
mind body and lifestyle management12
Mind, body and lifestyle management
  • Nutrition for fertility
    • Laying the foundations for a healthy pregnancy
slide22

“The kind and quantity of nutrition you received in the womb; the pollutants, drugs and infections you were exposed to during gestation; your mother\'s health, stress level and state of mind while she was pregnant with you — all these factors shaped you as a baby and a child and continue to affect you to this day.” – Annie Murphy Paul, Time Magazine

Pregnant Woman

Heide Benser / Corbis

mind body and lifestyle management13
Mind, body and lifestyle management
  • “the 12 month pregnancy”
mind body and lifestyle management14
Mind, body and lifestyle management
  • What is a good diet ?
    • The mythical balanced diet doesn’t exist
    • Women eat according to their hormones, moods and cycles
mind body and lifestyle management15
Mind, body and lifestyle management
  • What depletes our bodies of nutrients needed for fertility?
    • Alcohol
    • Stress
    • Exercise
    • Medications
    • Processed foods
    • Trans-fats
    • Sugar
    • Caffeine
mind body and lifestyle management16
Mind, body and lifestyle management
  • “ Nutrition is the most influential non-genetic factor in foetal development ”
      • Nutritional stores
      • Diet
      • Windows of opportunity
      • Foetal growth
      • Birth weight
      • Brain development
      • Pregnancy complications
    • All determined by the nutrients available to the foetus
mind body and lifestyle management17
Mind, body and lifestyle management
  • Factors for good fertility
    • Healthy Eggs
    • Healthy Sperm
    • Healthy Implantation
    • Environmental
    • Stress
    • Nutrition
    • Lifestyle
mind body and lifestyle management18
Mind, body and lifestyle management
  • What an egg needs
  • Q: Can I do anything to improve the quality of my eggs?’
      • Nutrition – most important
      • Blood flow - acupuncture
      • Lifestyle factors
      • Protection from free radicals
      • Diet rich in antioxidants
      • Managing blood sugar
mind body and lifestyle management19
Mind, body and lifestyle management
  • Healthy EggsFactors that effect Egg Quality
  • Age
  • DNA less stable
  • Blood flow reduced
  • Reduced hormonal fuel
      • Increased free radical damage
  • Environmental
  • Toxins
  • Diet and nutrition
  • Mental and emotional stress
  • Immune factors and inflammation
mind body and lifestyle management20
Mind, body and lifestyle management
  • Impact of Age
    • AMH AFC
    • Longer time to conceive
    • Fear about the biological clock
    • Increases in anxiety
    • Less sex
    • Fertile window
    • Egg quantity and quality decline with age
what a sperm needs
What a sperm needs

It takes two

mind body and lifestyle management22
Mind, body and lifestyle management
  • Factors affecting egg and sperm health
  • Reactive Oxygen Species (ROS)
  • Infections
  • Age
  • Weight
  • Processed foods and trans fats
  • Occupational hazards
  • Smoking
  • Alcohol
  • Caffeine
  • Drugs (prescribed and recreational)
  • Heat
implantation immune inflammation
Implantation, immune & inflammation

Recurrent miscarriage

IVF Failure

mind body and lifestyle management23
Mind, body and lifestyle management
  • Mayonnaise miracle babies!
mind body and lifestyle management24
Mind, body and lifestyle management
  • Nutritional testing
  • Vitamin / mineral deficiencies
    • Iodine
    • Essential fatty acids
    • Inositol
    • Vitamin D
    • Antioxidant profiles
    • Minerals / vitamins involved in hormone regulation and egg quality
mind body and lifestyle management25
Mind, body and lifestyle management
  • Lifestyle factors
  • Extremes:
    • All or nothing

Lifestyle factors and reproductive health: taking control of your fertility: Rakesh Sharma, Kelly R Biedenharn, Jennifer M Fedor and Ashok Agarwal: Reproductive Biology and Endocrinology 2013 11:66

mind body and lifestyle management26
Mind, body and lifestyle management
  • Common lifestyle questions
    • How much coffee?
    • How much alcohol?
    • Do recreational drugs have an impact?
    • How much exercise?
    • Can I have the odd cigarette?
    • Can stress affect my chances of getting pregnant?

Lifestyle factors and reproductive health: taking control of your fertility: Rakesh Sharma, Kelly R Biedenharn, Jennifer M Fedor and Ashok Agarwal: Reproductive Biology and Endocrinology 2013 11:66

mind body and lifestyle management27
Mind, body and lifestyle management
  • How much caffeine is OK?

Lifestyle factors and reproductive health: taking control of your fertility: Rakesh Sharma, Kelly R Biedenharn, Jennifer M Fedor and Ashok Agarwal: Reproductive Biology and Endocrinology 2013 11:66

mind body and lifestyle management28
Mind, body and lifestyle management
  • Caffeine
    • Increased time to get pregnant in females, especially over 500 mg per day
    • Risk of miscarriage at over 100 mg per day
    • Caffeine present in caffeinated drinks, coffee, tea, painkillers

Lifestyle factors and reproductive health: taking control of your fertility: Rakesh Sharma, Kelly R Biedenharn, Jennifer M Fedor and Ashok Agarwal: Reproductive Biology and Endocrinology 2013 11:66

mind body and lifestyle management29
Mind, body and lifestyle management
  • Is there a safe alcohol limit?

Lifestyle factors and reproductive health: taking control of your fertility: Rakesh Sharma, Kelly R Biedenharn, Jennifer M Fedor and Ashok Agarwal: Reproductive Biology and Endocrinology 2013 11:66

mind body and lifestyle management30
Mind, body and lifestyle management
  • Alcohol
      • Government recommendations are max 14 units a week but no national guidelines for women trying to conceive
      • Wine now stronger so a 750ml bottle of wine at 14% contains 10 units!
      • Many women (and men) drinking more than they think
      • Damage to eggs in women
      • Damage to sperm DNA in men leading to delayed conception and increased risk of miscarriage

Lifestyle factors and reproductive health: taking control of your fertility: Rakesh Sharma, Kelly R Biedenharn, Jennifer M Fedor and Ashok Agarwal: Reproductive Biology and Endocrinology 2013 11:66

mind body and lifestyle management31
Mind, body and lifestyle management
  • Alcohol
  • A man ‘steeped in wine ... is clumsy[in bed] and bad at sowing seed, and is thus likely to beget unstableand untrusty offspring, crooked in form and character.....’ (Plato circa 400BC)
  • BINGE DRINKING IN MEN
  • ↓ Testosterone levels
  • ↓ Folic acid
  • ↓ Libido and erectile function
  • ↑ Oxidative stress → DNA damage

Worst is lager, best is red wine, particularly Malbec, and Madiranfrom the Tannat grape (organic if possible)

mind body and lifestyle management32
Mind, body and lifestyle management
  • What about the occasional cigarette?

Lifestyle factors and reproductive health: taking control of your fertility: Rakesh Sharma, Kelly R Biedenharn, Jennifer M Fedor and Ashok Agarwal: Reproductive Biology and Endocrinology 2013 11:66

mind body and lifestyle management33
Mind, body and lifestyle management
  • Smoking
    • Reduces fertility, delays time to conception and reduces IVF success rates
    • In men: decrease in total sperm count and motility, DNA damage to sperm, depletion of nutrients need for sperm manufacture, implications for future heath of the child
    • In women: decreased fertility, DNA damage to eggs, disruption of hormone levels, lower pregnancy rates
    • Pregnancy

Lifestyle factors and reproductive health: taking control of your fertility: Rakesh Sharma, Kelly R Biedenharn, Jennifer M Fedor and Ashok Agarwal: Reproductive Biology and Endocrinology 2013 11:66

mind body and lifestyle management34
Mind, body and lifestyle management
  • Body Mass Index & Body Fat %
mind body and lifestyle management35
Mind, body and lifestyle management
  • Impact of body fat on fertility
mind body and lifestyle management36
Mind, body and lifestyle management
  • How common is recreational drug use?

Lifestyle factors and reproductive health: taking control of your fertility: Rakesh Sharma, Kelly R Biedenharn, Jennifer M Fedor and Ashok Agarwal: Reproductive Biology and Endocrinology 2013 11:66

mind body and lifestyle management37
Mind, body and lifestyle management
  • Recreational drugs
    • In men: reduced testosterone levels, decreased sperm motility
    • In women: hormonal disruption

Lifestyle factors and reproductive health: taking control of your fertility: Rakesh Sharma, Kelly R Biedenharn, Jennifer M Fedor and Ashok Agarwal: Reproductive Biology and Endocrinology 2013 11:66

mind body and lifestyle management39
Mind, body and lifestyle management
  • Zita West Clinics in Ireland
    • Dublin and Cork
  • Zita West Affiliated Acupuncturists
    • www.zitawest.com
  • Blog
    • zitawestblog.com
  • e Newsletter
    • see the website
mind body and lifestyle management40
Mind, body and lifestyle management
  • References: Acupuncture for fertility
  • Reviews:
    • Manheimer E et al.,Effects of acupuncture on rates of pregnancy and live birth rates among women undergoing IVF: systematic review and meta-analysis, BMJ 7 Feb 2008; oi:10.1136/bmj.39471.430451.BE
    • Stener-Victorin E, Wu X. Effects and mechanisms of acupuncture in the reproductive system. AutonNeurosci. 2010 Mar 27. [Epub ahead of print]
    • Lim CE, Wong WS. Current evidence of acupuncture on polycystic ovarian syndrome.GynecolEndocrinol. 2010 Mar 16. [Epub ahead of print]
    • Ng EH, So WS, Gao J, Wong YY, Ho PC. The role of acupuncture in the management of subfertility. Fertil Steril. 2008 Jul;90(1):1-13.
    • Huang ST, Chen AP. Traditional Chinese medicine and infertility. Curr OpinObstetGynecol. 2008 Jun;20(3):211-5.
    • Stener-VictorinE, Jedel E, Manners L. Acupuncture in polycystic ovary syndrome: current experimental and clinical evidence. J Neuroendocrinol. 2008 Mar;20(3):290-8.
    • Stener-VictorinE, Humaidan P. Use of acupuncture in female infertility and a summary of recent acupuncture studies related to embryo transfer. Acupunct Med. 2006 Dec;24(4):157-63.
    • Clinical trials
    • Park JJ, Kang M, Shin S, Choi E et al. Unexplained infertility treated with acupuncture and herbal medicine in Korea. J Altern Complement Med. 2010 Feb;16(2):193-8.
    • Jiang DS. Ding D. [Clinical observation on acupuncture combined with medication for treatment of continuing anovulation infertility]. [Chinese] ZhongguoZhenjiu. 29(1):21-4, 2009 Jan.
    • Song FJ. Zheng SL. Ma DZ. [Clinical observation on acupuncture for treatment of infertility of ovulatory disturbance]. [Chinese] ZhongguoZhenjiu. 28(1):21-3, 2008 Jan.
    • Chen D. Chen SR. Shi XL. Guo FL. Zhu YK. Li S. Cai MX. Deng LH. Xu H. [Clinical study on needle-pricking therapy for treatment of polycystic ovarial syndrome]. [Chinese] Zhongguo Zhenjiu. 27(2):99-102, 2007 Feb.
    • Yang JR, Ma YY, Liu YL, Wang HL, Liu Z. [Controlled study on acupuncture for treatment of endocrine dysfunctional infertility] [Chinese]. Zhongguo Zhenjiu. 2005;25(5):299-300
    • Stener-VictorinE, Waldenström U, Tägnfors U, Lundeberg T, Lindstedt G, Janson PO. Effects of electro-acupuncture on anovulation in women with polycystic ovary syndrome Acta Obstet Gynecol Scand. 2000 Mar;79(3):180-8.
    • Gerhard I, Postneek F. Auricular acupuncture in the treatment of female infertility. Gynecol Endocrinol. 1992 Sep;6(3):171-81.
    • Physiology studies (human and animal)
    • Stener-VictorinE, Jedel E, Janson PO, Sverrisdottir YB. Low-frequency electro-acupuncture and physical exercise decrease high muscle sympathetic nerve activity in polycystic ovary syndrome. Am J Physiol Regul Integr Comp Physiol. 2009 Aug;297(2):R387-95.
    • Zhang WY, Huang GY, Liu J. [Influences of acupuncture on infertility of rats with polycystic ovarian syndrome] [in Chinese] Zhongguo Zhong Xi Yi Jie He Za Zhi. 2009 Nov;29(11):997-1000.
    • He D.J. Huang G.Y. Zhang M.M. [Effects of acupuncture on the luteal function of rats with dysfunctional embryo implantation] [Chinese]. Zhongguo zhen jiu. 2009; 29(11):910-913
    • Stener-VictorinE, Waldenström U, Andersson SA, Wikland M. Reduction of blood flow impedance in the uterine arteries of infertile women with electro-acupuncture. Hum Reprod. 1996 Jun;11(6):1314-7.
mind body and lifestyle management41
Mind, body and lifestyle management
  • References: male fertility
    • VisserL, Repping S. Unravelling the genetics of spermatogenic failure. Reproduction. 2010 Feb;139(2):303-7.
    • Jorgensen N, Joensen UN, Jensen TK, et al. Human semen quality in the new millennium: a prospective cross-sectional population-based study of 4867 men. BMJ Open. 2012;2(4).
    • Merzenich H, Zeeb H, Blettner M. Decreasing sperm quality: a global problem? BMC Public Health. 2010;10:24.
    • Jurewicz J, Hanke W. Exposure to phthalates: reproductive outcome and children health. A review of epidemiological studies. Int J Occup Med Environ Health. 2011 Jun;24(2):115-41. Epub 2011 May 19
    • Shiva M, Gautam AK, Verma Y, Shivgotra V, Doshi H, Kumar S. Association between sperm quality, oxidative stress, and seminal antioxidant activity. Clin Biochem. 2011 Mar;44(4):319-24.
    • Ibrahim HA, Zhu Y, Wu C, et al. Selenium-enriched probiotics improves murine male fertility compromised by high fat diet. Biol Trace Elem Res. 2012 Jun;147(1-3):251-60.
    • Zini A, San Gabriel M, Baazeem A. Antioxidants and sperm DNA damage: a clinical perspective. J Assist Reprod Genet. 2009 Aug;26(8):427-32.
    • Lenzi A, Lombardo F, Sgro P, et al. Use of carnitine therapy in selected cases of male factor infertility: a double-blind crossover trial. Fertil Steril. 2003 Feb;79(2):292-300.
    • Khademi A, Alleyassin A, Safdarian L, Hamed EA, Rabiee E, Haghaninezhad H. The effects of L-carnitine on sperm parameters in smoker and non-smoker patients with idiopathic sperm abnormalities. J Assist Reprod Genet. 2005 Dec;22(11-12):395-9.
    • Wang YX, Yang SW, Qu CB, et al. L-carnitine: safe and effective for asthenozoospermia. Zhonghua Nan Ke Xue. 2010 May;16(5):420-2.
    • Cavallini G, Ferraretti AP, Gianaroli L, Biagiotti G, Vitali G. Cinnoxicam and L-carnitine/acetyl-L-carnitine treatment for idiopathic and varicocele-associated oligoasthenospermia. J Androl. 2004 Sep-Oct;25(5):761-70; discussion 71-2.
    • Auger J, Eustache F, Andersen AG, Irvine DS, JørgensenN, Skakkebaek NE et al. Sperm morphological defects related to environment, lifestyle and medical history of 1001 male partners of pregnant women from four European cities. Hum Reprod. (2001) 16:2710–7.
    • Showell MG, Brown J, Yazdani A, Stankiewicz MT, Hart RJ. Antioxidants for male subfertility. Cochrane Database Syst Rev. (2011) Jan 19(1):CD007411.
    • Colagar AH, Marzony ET. Ascorbic Acid in human seminal plasma: determination and its relationship to sperm quality. J Clin Biochem Nutr. 2009 Sep;45(2):144-9.
    • Dawson EB, Harris WA, Teter MC, Powell LC. Effect of ascorbic acid supplementation on the sperm quality of smokers. Fertil Steril. 1992 Nov;58(5):1034-9.
    • Kessopoulou E, Powers HJ, Sharma KK, et al. A double-blind randomized placebo cross-over controlled trial using the antioxidant vitamin E to treat reactive oxygen species associated male infertility. Fertil Steril. 1995 Oct;64(4):825-31.
    • Suleiman SA, Ali ME, Zaki ZM, el-Malik EM, Nasr MA. Lipid peroxidation and human sperm motility: protective role of vitamin E. J Androl. 1996 Sep-Oct;17(5):530-7
    • Scott R, MacPherson A, Yates RW, Hussain B, Dixon J. The effect of oral selenium supplementation on human sperm motility. Br J Urol. 1998 Jul;82(1):76-80
    • Wong WY, Merkus HM, Thomas CM, Menkveld R, Zielhuis GA, Steegers-Theunissen RP. Effects of folic acid and zinc sulfate on male factor subfertility: a double-blind, randomized, placebo-controlled trial. Fertil Steril. 2002 Mar;77(3):491-8.
    • Ciftci H, Verit A, Savas M, Yeni E, Erel O. Effects of N-acetylcysteine on semen parameters and oxidative/antioxidant status. Urology. 2009 Jul;74(1):73-6.
    • Gupta NP, Kumar R. Lycopene therapy in idiopathic male infertility--a preliminary report. Int Urol Nephrol. 2002;34(3):369-72.
    • Aksoy Y, Aksoy H, Altinkaynak K, Aydin HR, Ozkan A. Sperm fatty acid composition in subfertile men. Prostaglandins Leukot Essent Fatty Acids. 2006 Aug;75(2):75-9.
    • Safarinejad MR. Effect of omega-3 polyunsaturated fatty acid supplementation on semen profile and enzymatic anti-oxidant capacity of seminal plasma in infertile men with idiopathic oligoasthenoteratospermia: a double-blind, placebo-controlled, randomised study. Andrologia. 2011 Feb;43(1):38-47.
    • Vujkovic M, de Vries JH, Lindemans J, et al. The preconception Mediterranean dietary pattern in couples undergoing in vitro fertilization/intracytoplasmic sperm injection treatment increases the chance of pregnancy. Fertil Steril. 2010 Nov;94(6):2096-101.
    • Blomberg Jensen M, Bjerrum PJ, Jessen TE, et al. Vitamin D is positively associated with sperm motility and increases intracellular calcium in human spermatozoa. Hum Reprod. 2011 Jun;26(6):1307-17.
    • Wong WY, Merkus HM, Thomas CM, Menkveld R, Zielhuis GA, Steegers–Theunissen RP. Effects of folic acid and zinc sulfate on male factor subfertility: a double–blind, randomized, placebo–controlled trial. Fertil Steril. 2002 Mar. 77(3):491–8.
mind body and lifestyle management42
Mind, body and lifestyle management
  • References: male fertility
  • Stewart AF, Kim ED: Fertility concerns for the aging male. Urology 2011, 78:496–499.
  • Dunson DB, Baird DD, Colombo B: Increased infertility with age in men and women. Obstet Gynecol 2004, 103:51–56.
  • Varshini J, Srinag BS, Kalthur G, Krishnamurthy H, Kumar P, Rao SB, Adiga SK:Poor sperm quality and advancing age are associated with increased
  • sperm DNA damage in infertile men. Andrologia 2012, 44(Suppl 1):642–649.
  • Mutsaerts MA, Groen H, Huiting HG, Kuchenbecker WK, Sauer PJ, Land JA, Stolk RP, Hoek A: The influence of maternal and paternal factors on time to pregnancy–a dutch population-based birth-cohort study: the GECKO drenthe study. Hum Reprod 2012, 27:583–593.
  • Hassan MA, Killick SR: Effect of male age on fertility: Evidence for the decline in male fertility with increasing age. Fertil Steril 2003, 79(Suppl 3):1520–1527.
  • Matorras R, Matorras F, Exposito A, Martinez L, Crisol L: Decline in human fertility rates with male age: a consequence of a decrease in male fecundity with aging? Gynecol Obstet Invest 2011, 71:229–235.
  • Mendiola J, Torres-Cantero AM, Vioque J, Moreno-Grau JM, Ten J, Roca M, Moreno-Grau S, Bernabeu R: A low intake of antioxidant nutrients is associated with poor semen quality in patients attending fertility clinics. Fertil Steril 2010, 93:1128–1133.
  • Wong WY, Zielhuis GA, Thomas CM, Merkus HM, Steegers-Theunissen RP: New evidence of the influence of exogenous and endogenous factors on sperm count in man. Eur J Obstet Gynecol Reprod Biol 2003, 110:49–54. 16. Cocuzza M, Sikka SC, Athayde KS, Agarwal A: Clinical relevance of oxidative stress and sperm chromatin damage in male infertility: an evidence based analysis. Int Braz J Urol 2007, 33:603–621.
  • Silver EEW: Effect of antioxidant intake on sperm chromatin stability in healthy nonsmoking men. J Androl 2 Sharma et al. Reproductive Biology and Endocrinology 2013, 11:66
  • Keskes-Ammar LL: Sperm Oxidative stress and the effect of an oral vitamin E and selenium supplement on semen quality in infertile men. Syst Biol Reprod Med 2003, 49:83–94.
  • Suleiman SA: Lipid peroxidation and human sperm motility: Protective role of vitamin E. J Androl 1996, 17:530.
  • Gharagozloo P, Aitken RJ: The role of sperm oxidative stress in male infertility and the significance of oral antioxidant therapy. Hum Reprod 2011, 26:1628–1640.
  • Showell MG, Brown J, Yazdani A, Stankiewicz MT, Hart RJ: Antioxidants for male subfertility. Cochrane Database of Systematic Reviews (Online) 2011. 1:CD007411, doi:10:1002/14651858.
  • Chavarro JE, Rich Edwards JW, Rosner BA, Willett WC: Diet and lifestyle in the prevention of ovulatory disorder infertility. Obstet Gynecol2007,110:1050–1058.
  • Brannian JD: Obesity and fertility. S D Med 2011, 64:251–254.
  • Sallmen M, Sandler DP, HoppinJA, Blair A, Baird DD: Reduced fertility among overweight and obese men. Epidemiology 2006, 17:520–523.
  • Magnusdottir EV, Thorsteinsson T, Thorsteinsdottir S, Heimisdottir M, Olafsdottir K: Persistent organochlorines, sedentary occupation, obesity and human male subfertility. Hum Reprod 2005, 20:208–215.
  • Jensen TK, Andersson AM, Jorgensen N, Andersen AG, Carlsen E, Petersen JH,Skakkebaek NE: Body mass index in relation to semen quality and reproductive hormones among 1,558 danish men. Fertil Steril 2004, 82:863–870.
  • Hammoud AO, Wilde N, Gibson M, Parks A, Carrell DT, Meikle AW: Male obesity and alteration in sperm parameters. Fertil Steril 2008, 90:2222–2225.
  • Martini AC, Tissera A, Estofán D, Molina RI, Mangeaud A, de Cuneo MF, Ruiz RD: Overweight and seminal quality: a study of 794 patients. Fertil Steril 2010, 94:1739–1743.
  • Chavarro JE, Toth TL, Wright DL, Meeker JD, Hauser R: Body mass index in relation to semen quality, sperm DNA integrity, and serum reproductive hormone levels among men attending an infertility clinic. Fertil Steril 2010, 93:2222–22231.
  • Kort HI, Massey JB, Elsner CW, Mitchell-Leef D, Shapiro DB, Witt MA, Roudebush WE: Impact of body mass index values on sperm quantity and quality. J Androl 2006, 27:450–452.
  • Makhsida N, Shah J, Yan G, Fisch H, Shabsigh R: Hypogonadism and metabolic syndrome: implications for testosterone therapy. J Urol 2005, 174:827–834.
  • Winters SJ, Wang C, Abdelrahaman E, Hadeed V, Dyky MA, Brufsky A: Inhibin-B levels in healthy young adult men and prepubertal boys: Is obesity the cause for the contemporary decline in sperm count because of fewer sertoli cells? J Androl 2006, 27:560–564.
  • Ghanayem BI, Bai R, Kissling GE, Travlos G, Hoffler U: Diet-induced obesity in male mice is associated with reduced fertility and potentiation of acrylamide-induced reproductive toxicity. Biol Reprod 2010, 82:96–104.
nutrition for fertility
Nutrition for fertility
  • References: female fertility
  • Chandra A, Martinez GM, Mosher WD, Abma JC, Jones J: Fertility, family planning, and reproductive health of U.S. women: data from the 2002 national survey of family growth. Vital Health Stat 2005, 25:1–160.
  • Homan GF, Davies M, Norman R: The impact of lifestyle factors on reproductive performance in the general population and those undergoing infertility treatment: a review. Hum Reprod Update 2007, 13:209–223.
  • Dunson DB, Baird DD, Colombo B: Increased infertility with age in men and women. Obstet Gynecol 2004, 103:51–56.
  • Kimberly L, Case A, Cheung AP, Sierra S, AlAsiri S, Carranza-Mamane B, Case A, Dwyer C, Graham J, Havelock J, et al: Advanced reproductive age and fertility: No. 269, November 2011. Int J Gynaecol Obstet 2012, 117:95–102.
  • MatorrasR, Matorras F, Exposito A, Martinez L, Crisol L: Decline in human fertility rates with male age: a consequence of a decrease in male fecundity with aging? Gynecol Obstet Invest 2011, 71:229–235.
  • GianaroliL, Magli MC, Cavallini G, Crippa A, Capoti A, Resta S, Robles F, Ferraretti AP: Predicting aneuploidy in human oocytes: key factors which affect the meiotic process. Hum Reprod 2010, 25:2374–2386.
  • Kroon B, Harrison K, Martin N, Wong B, Yazdani A: Miscarriage karyotype and its relationship with maternal body mass index, age, and mode of conception. Fertil Steril 2011, 95:1827–1829.
  • Munné S, Held KR, Magli CM, Ata B, Wells D, Fragouli E, Baukloh V, Fischer R, Gianaroli L: Intra-age, intercenter, and intercycle differences in chromosome abnormalities in oocytes. Fertil Steril 2012, 97:935–942.
  • MendiolaJ, Torres-Cantero AM, Vioque J, Moreno-Grau JM, Ten J, Roca M,
  • Moreno-Grau S, Bernabeu R: A low intake of antioxidant nutrients is associated with poor semen quality in patients attending fertility clinics. Fertil Steril 2010, 93:1128–1133.
  • ChavarroJE, Rich-Edwards JW, Rosner BA, Willett WC: Dietary fatty acid intakes and the risk of ovulatory infertility. Am J Clin Nutr 2007, 85:231–237.
  • BrannianJD: Obesity and fertility. S D Med 2011, 64:251–254.
  • CablerS, Agarwal A, Flint M, du Plessis SS: Obesity: modern man\'s fertility nemesis. Asian J Androl 2010, 12:480–489.
  • Martini AC, Tissera A, Estofán D, Molina RI, Mangeaud A, de Cuneo MF,
  • Corona G, Mannucci E, Schulman C, Petrone L, Mansani R, Cilotti A, Balercia G, Chiarini V, Forti G, Maggi M: Psychobiologic correlates of the metabolic syndrome and associated sexual dysfunction. Eur Urol 2006, 50:595,604. discussion 604.
  • Boots C, Stephenson MD: Does obesity increase the risk of miscarriage in spontaneous conception: A systematic review. Semin Reprod Med 2011, 29:507–513.
  • LandresIV, Milki AA, Lathi RB: Karyotype of miscarriages in relation to maternal weight. Hum Reprod 2010, 25:1123–1126.
mind body and lifestyle management43
Mind, body and lifestyle management
  • References

Iodine

AnderssonM et al (2007) Iodine Deficiency in Europe: a continuing public health problem. World Health Orgnisationhttp://whqlibdoc.who.int/publications/2007/9789241593960_eng.pdfAceves C, Anguiano B, Delgado G (2005) Is iodine a gatekeeper of the integrity of the mammary gland? J Mammary Gland Biol Neoplasia. 2005 Apr;10(2):189-96.

Bath SC and Rayman MP (2012) Iodine deficiency in the UK: an overlooked cause of impaired neurodevelopment? The Summer meeting of the Nutrition Society, Queen\'s University, Belfast. 16–19 July 2012 in Proceedings of the Nutrition Society Proceedings of the Nutrition Society / Volume 72 / Issue 02 / May 2013, pp 226-235

Ghent WR, Eskin BA, Low DA, Hill LP (1993) Iodine replacement in fibrocystic disease of the breast. Can J Surg. 1993;36(5):453-460.  

Kessler JH (2004) The effect of supraphysiologic levels of iodine on patients with cyclic mastalgia. Breast J. 2004;10(4):328-336.  

Patrick L (2008) Iodine: deficiency and therapeutic considerations. Altern Med Rev. 2008 Jun;13(2):116-27.

Smyth PPA (2003): The thyroid, iodine and breast cancer. Breast Cancer Research 5(5): 235–238.

Topper YJ, Freeman CS (1980) Multiple hormone interactions in the developmental biology of the mammary gland. Physiol Rev 1980 Oct;60(4):1049-106

Vanderpump MP, Lazarus JH, Smyth PP, Laurberg P, Holder RL, Boelaert K, Franklyn JA (2011): Iodine status of UK schoolgirls: a cross-sectional survey Lancet. 2011 Jun 11, Epub 2011 Jun 2.

Ziegler RG, Hoover RN, Pike MC, et al (1993): Migration patterns and breast cancer risk in Asian-American women. J Natl Cancer Inst. 1993 Nov 17;85(22):1819-27.

Inositol

Allan SJ, Kavanagh GM, Herd RM, SavinJA (2004). The effect of inositol supplements on the psoriasis of patients taking lithium: a randomized, placebo-controlled trial. Br J Dermatol 2004;150:966-9.

Chiu TT, Rogers MS, Law EL, Briton-Jones CM, Cheung LP, Haines CJ (2002) Follicular fluid and serum concentrations of myo-inositol in patients undergoing IVF: relationship with oocyte quality. Hum Reprod 2002;17(6):1591–6.

Chiu TTY, Rogers MS, Briton-Jones C, Haines C (2003). Effects of myo-inositol on the in vitro maturation and subsequent development of mouse oocytes. Hum Reprod 2003;18:408–16

Ciotta L, et al (2011) Effects of myo-inositol supplementation on oocyte\'s quality in PCOS patients: a double blind trial.Eur Rev Med Pharmacol Sci. May;15(5):509-14.

Costantino D, Minozzi G, Minozzi E, Guaraldi C (2009) Metabolic and hormonal effects of myo-inositol in women with polycystic ovary syndrome: a double-blind trial J Eur Rev Med Pharmacol Sci. 2009 Mar-Apr;13(2):105-10.

Gerli S, Papaleo E, Ferrari A, Di Renzo GC (2007) Randomized, double blind placebo-controlled trial: effects of myo-inositol on ovarian function and metabolic factors in women with PCOS J Eur Rev Med Pharmacol Sci. 2007 Sep-Oct;11(5):347-54.

Minozzi et al. Treatment of hirsutism with myo-inositol: a prospective clinical study. Reprod Biomed Online (2008)

Palatnik A, Frolov K, Fux M, Benjamin J (2001). Double-blind, controlled, crossover trial of inositol versus fluvoxamine for the treatment of panic disorder. J ClinPsychopharmacol 2001;21:335-9.

Papaleo E, Unfer V, Baillargeon JP, De Santis L, Fusi F, Brigante C, Marelli G, Cino I, Redaelli A, Ferrari A (2007) Myo-inositol in patients with polycystic ovary syndrome: a novel method for ovulation induction GynecolEndocrinol. 2007 Dec;23(12):700-3. Epub 2007 Oct 10

PapaleoE, Unfer V, Baillargeon JP, Fusi F, Occhi F, De Santis L (2009) Myo-inositol may improve oocyte quality in intracytoplasmic sperm injection cycles. A prospective, controlled, randomized trial. FertilSteril. 2009 May;91(5):1750-4. doi: 10.1016/j.fertnstert.2008.01.088. Epub 2008 May 7.

Papaleo et al (2009b) Contribution of myo-inositol to reproduction. Eur J ObstetGynecol (2009)

Papaleo et al (2009c). Myo-inositol may Improve oocyte quality in intracytoplasmatic sperm injection cycles. A prospective, controlled, randomized trial. FertilSterilPapaleo et al. Myo-inositol may Improve oocyte quality in intracytoplasmatic sperm injection cycles. A prospective, controlled, randomized trial. FertilSteril (2008)

Papaleo et al. Comparison of myo-inositol plus folic acid vs clomiphene citrate for first-line treatment in women with polycystic ovary syndrome. O-251 Oral (ESHRE 2008)

Raffone et al. Insulin sensitiser agents alone and in co-treatment with rFSH for ovulation induction in PCOS women. Gynecological Endocrinology (2010)

Unfer V, Raffone E, Rizzo P, Buffo S (2011) Effect of a supplementation with myo-inositol plus melatonin on oocyte quality in women who failed to conceive in previous in vitro fertilization cycles for poor oocyte quality: a prospective, longitudinal, cohort study. GynecolEndocrinol. 2011 Nov;27(11):857-61. doi: 10.3109/09513590.2011.564687. Epub 2011 Apr 5.

Zacchè MM, Caputo L, Filippis S, Zacchè G, Dindelli M, Ferrari A (2009) Efficacy of myo-inositol in the treatment of cutaneous disorders in young women with polycystic ovary syndrome GynecolEndocrinol. 2009 Aug;25(8):508-13. doi: 10.1080/09513590903015544.

mind body and lifestyle management44
Mind, body and lifestyle management
  • References

Vitamin D

Aghajafari. F, Nagulesapillai, T Ronksley PE, Tough SC, O’Beirne M. Rabi DM (2013): Association between maternal serum 25-hydroxyvitamin D level and pregnancy and neonatal outcomes: systematic review and meta-analysis of observational studies, BMJ 2013(Published 27 March 2013)

Anagnostis P, Karras S, Goulis DG (2013) Vitamin D in human reproduction: A narrative review, Int J ClinPract. 2013 Mar

Brannon PM (2012): Vitamin D and adverse pregnancy outcomes: beyond bone health and growth ProcNutr Soc. 2012 May Epub 2012 Jan 20

Garbedian K, Boggild M, Moody J, Liu KE (2013): Effect of vitamin D status on clinical pregnancy rates following in vitro fertilization: Journal of the Canadian Medical Association

GrundmannM and von Versen-Hovnck F (2011) Vitamin D - Roles in women’s reproductive health, ReprodBiolEndocrinol. 2011:9:146. Published online 2011 November 2.

LerchbaumE, ObennayerPietsch BM: Vitamin D and fertility - a systematic review. European Journal of Endocrinology. Published online before print

January 24 2012, Eur J Endocrinol May 1 2012

OzkanS, Jindal S, Greenseid K, Shu J, Zeitlian G, Hickman C. Pal L (2010): Replete vitamin D stores predict reproductive success following in vitro fertilization: FertilSteril. 2010 Sep, Epub 2009 Jul 8.

Pludowski P, Holick MF, Pilz S. Wagner CL, Hollis BW, Grant WB, Shoenfeld

Y. Lerchbaum E, Llewellyn DJ, Kienreich K, Soni M (2013): Vitamin D effects on musculoskeletal health, immunity, autoimmunity, cardiovascular disease, cancer, fertility, pregnancy, dementia and mortality - a review of recent evidence: AutoImmun Rev. 2013 Aug 12, Epub 2013 Mar 28.

Rudick B, Ingles S, Chung K, Stanczyk F, Paulson R, Bendikson K (2012):

Characterizing the influence of vitamin D levels on IVF outcomes Hum

Reprod. 2012 Nov 27, Epub 2012 Aug 21.

Wagner CL, Taylor SN, Johnson DD, Hollis BW (2012): The role of vitamin D in pregnancy and lactation: emerging concepts Women’s Health (LondEngl). 2012 May 8.

EFAs

Wathes C D, Abayasekara D R E, Aitken R J, Polyunsaturated Fatty Acids in Male and Female Reproduction. Biology of Reproduction 2007; 77:190-201

Kim JY, Kinoshita M, Oshnishi M, Fukui Y, Lipid and fatty acid analysis of fresh and frozen-thawed immature and in-vitro matured bovine oocytes. Reproduction 2001; 122:131-138

Rossi E, Costa M Fish oil derivatives as a prophylaxis of recurrent miscarriage associated with antiphospholipid antibodies (APL). A Pilot Study. Lupus 1993;2:319323

Rump P, Mensink RP, Kester ADM, Hornstra G. Essential Fatty Acids composition of plasma phospholipids and birthweight; a study in term neonates. American Journal of Clinical Nutrition 2001;73:797-806

Hibbeln JR. Seafood Consumption; the DHA content of mother’s milk and prevalent rates of post partum depression. A cross-national ecological anaysis. Journal of Affective Disorders 2002;69:15-29

Aksoy Y, Aksoy H, Altinkaynak K, Aydin HR, Ozkan A. Sperm fatty acid composition in subfertile men. Prostaglandins LeukotEssent Fatty Acids. 2006 Aug;75(2):75-9.

ObornaI, Wojewodka G, De SanctisJB, et al. Increased lipid peroxidation and abnormal fatty acid profiles in seminal and blood plasma of normozoospermic males from infertile couples. Hum Reprod. 2010 Feb;25(2):308-16.

Safarinejad MR, HosseiniSY, Dadkhah F, Asgari MA. Relationship of omega-3 and omega-6 fatty acids with semen characteristics, and anti-oxidant status of seminal plasma: a comparison between fertile and infertile men. ClinNutr. 2010 Feb;29(1):100-5.

BrinskoSP, Varner DD, Love CC, Blanchard TL, Day BC, Wilson ME. Effect of feeding a DHA-enriched nutriceutical on the quality of fresh, cooled and frozen stallion semen. Theriogenology.2005 Mar 15;63(5):1519-27.

Gholami H, Chamani M, Towhidi A, Fazeli MH. Effect of feeding a docosahexaenoic acid-enriched nutriceutical on the quality of fresh and frozen-thawed semen in Holstein bulls. Theriogenology.2010Dec;74(9):1548-58.

Safarinejad MR. Effect of omega-3 polyunsaturated fatty acid supplementation on semen profile and enzymatic anti-oxidant capacity of seminal plasma in infertile men with idiopathic oligoasthenoteratospermia: a double-blind, placebo-controlled, randomised study. Andrologia.2011Feb;43(1):38-47.

ad