In brain, one of the principal GSLs is sulfatide (SF), sulfated derivative of GalCer.
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In brain, one of the principal GSLs is sulfatide (SF), sulfated derivative of GalCer. Altered SF level is implicated in Alzheimer’s and Parkinson’s diseases, multiple sclerosis, progressive epilepsy with mental retardation and other neurodegenerative human disorders. Goals:

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In brain, one of the principal GSLs is sulfatide (SF), sulfated derivative of GalCer.

Altered SF level is implicated in Alzheimer’s and Parkinson’s diseases, multiple sclerosis, progressive epilepsy with mental retardation and other neurodegenerative human disorders

  • Goals:

  • To determine how SO3 group affects SF anchoring to GLTP

  • To switch GLTP for SF selectivity

2-


SF head group binding to GLTP sulfated derivative of GalCer.

K55I

K55F

K55Y

K55Q

K55E

K55N


“OUT” sulfated derivative of GalCer.

“IN”

D48V

WT


PART III. sulfated derivative of GalCer.Structural Basis for Suppression of Human Trinucleotide Repeat Expansion Diseases (TREDs)

  • repeated CNG-triplet sequences in genes

  • dynamically unstable, tend to expand

  • expanded tracts cause many muscle- and

  • neurodegenerative diseases


H sulfated derivative of GalCer.

Y

P

O

T

H

E

S

I

S



pGG(C small interfering RNA by a viral suppressor of RNA silencing. AG)5CC

pUUG(CUG)5CU

• • • • • • •

• • • • • •

CC(GAC)5GGp

UC(GUC)5GUUp

A•A

G•G

U•U

C•C


3? small interfering RNA by a viral suppressor of RNA silencing.

1

2


Sequence specific p19? small interfering RNA by a viral suppressor of RNA silencing.

2

3

CNGCNGCNG

• • • • • • • • •

GNCGNCGNC


Come to Bilbao small interfering RNA by a viral suppressor of RNA silencing.

Research Team

Borja Ochoa

Jevgenia Tamjar

Felipe Goñi

Elizaveta Katorcha

Sergey Ivaninskiy

Valeria Samygina

Aintzane Cabo

Sandra Delgado


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