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In brain, one of the principal GSLs is sulfatide (SF), sulfated derivative of GalCer.

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In brain, one of the principal GSLs is sulfatide (SF), sulfated derivative of GalCer. - PowerPoint PPT Presentation


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In brain, one of the principal GSLs is sulfatide (SF), sulfated derivative of GalCer. Altered SF level is implicated in Alzheimer’s and Parkinson’s diseases, multiple sclerosis, progressive epilepsy with mental retardation and other neurodegenerative human disorders. Goals:

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slide1

In brain, one of the principal GSLs is sulfatide (SF), sulfated derivative of GalCer.

Altered SF level is implicated in Alzheimer’s and Parkinson’s diseases, multiple sclerosis, progressive epilepsy with mental retardation and other neurodegenerative human disorders

  • Goals:
  • To determine how SO3 group affects SF anchoring to GLTP
  • To switch GLTP for SF selectivity

2-

slide2

SF head group binding to GLTP

K55I

K55F

K55Y

K55Q

K55E

K55N

slide3

“OUT”

“IN”

D48V

WT

slide4

PART III.Structural Basis for Suppression of Human Trinucleotide Repeat Expansion Diseases (TREDs)

  • repeated CNG-triplet sequences in genes
  • dynamically unstable, tend to expand
  • expanded tracts cause many muscle- and
  • neurodegenerative diseases
slide5

H

Y

P

O

T

H

E

S

I

S

slide6

Ye, K., Malinina, L., and Patel, D.J. (2003) Recognition of small interfering RNA by a viral suppressor of RNA silencing. Nature 426, 874-878

slide7

pGG(CAG)5CC

pUUG(CUG)5CU

• • • • • • •

• • • • • •

CC(GAC)5GGp

UC(GUC)5GUUp

A•A

G•G

U•U

C•C

slide8

3?

1

2

slide9

Sequence specific p19?

2

3

CNGCNGCNG

• • • • • • • • •

GNCGNCGNC

slide10

Come to Bilbao

Research Team

Borja Ochoa

Jevgenia Tamjar

Felipe Goñi

Elizaveta Katorcha

Sergey Ivaninskiy

Valeria Samygina

Aintzane Cabo

Sandra Delgado

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