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Acute Respiratory Distress Syndrome It’s so shocking, I can’t breathe!

Acute Respiratory Distress Syndrome It’s so shocking, I can’t breathe!. Heidi Ditmyer DVM University of Tennessee College of Veterinary Medicine Department of Pathobiology Tifton 2008. Signalment. Juvenile Female Spayed Yorkshire Terrier Presented to rDVM after chewing electric cord

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Acute Respiratory Distress Syndrome It’s so shocking, I can’t breathe!

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  1. Acute Respiratory Distress SyndromeIt’s so shocking, I can’t breathe! Heidi Ditmyer DVM University of Tennessee College of Veterinary Medicine Department of Pathobiology Tifton 2008 Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only

  2. Signalment • Juvenile Female Spayed Yorkshire Terrier • Presented to rDVM after chewing electric cord • rDVM treated with Oxygen and diuretics Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only

  3. Case 07-796 • Referred to UT • Ventilator • Febrile • Died 24 hours post arrival Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only

  4. Gross Findings • Glossal and gingival ulceration • Bilateral interstitial pneumonia • Congenital portosystemic shunt Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only

  5. Glossal ulceration Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only

  6. Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only

  7. Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only

  8. Histology and etiology • Fibrinous interstitial pneumonia • Multiple possibilities • Consistent with Acute Respiratory Distress Syndrome Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only

  9. Acute Respiratory Distress Syndrome (ARDS) • Acute onset • Bilateral/diffuse pulmonary changes • Hypoxemia • No evidence of left atrial hypertension Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only

  10. ARDS • Secondary inflammatory response • Macrophages  cytokines  enzymes  free radicals  diffuse alveolar and endothelial damage • Differential diagnosis for any animal with non-cardiogenic pulmonary edema and appropriate risk factors Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only

  11. Conclusion • Limited lung response regardless of trigger • Overzealous inflammatory response • Pathophysiology not entirely understood • Considered as differential diagnosis Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only

  12. Acknowledgements • Dr Kim Newkirk • UT histology staff Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only

  13. Thank you www.k9station.com Questions? Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only

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