JAMA Pediatrics Journal Club Slides: Prenatal Exposure to Cocaine and Tobacco.
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JAMA Pediatrics Journal Club Slides:Prenatal Exposure to Cocaine and Tobacco
Liu J, Lester BM, Neyzi N, et al. Regional brain morphometry and impulsivity in adolescents following prenatal exposure to cocaine and tobacco. JAMA Pediatr. Published online February 11, 2013. doi:10.1001/jamapediatrics.2013.550.
The cortical thickness estimate for the right DLPFC was significantly reduced in PCE subjects compared with subjects with no PCE (mean [SD], 2.18 [0.15] vs 2.30 [0.14] mm; P = .03).
On the Sensation Seeking Scale for Children, more impulsivity was related to a larger thalamus in exposed subjects in both the PCE group (PCE: r = 0.47, P = .05; no PCE: r = 0.35, P = .14) and PTE group (PTE: r = 0.44, P = .04; no PTE: r = 0.22, P = .41).
Correlations between Conners’ Continuous Performance Test commission errors and caudate volume were of borderline significance in the PCE group (PCE: r = 0.44, P = .06; no PCE: r = −0.10, P = .68).
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