JAMA Pediatrics Journal Club Slides: Prenatal Exposure to Cocaine and Tobacco.
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Liu J, Lester BM, Neyzi N, et al. Regional brain morphometry and impulsivity in adolescents following prenatal exposure to cocaine and tobacco. JAMA Pediatr. Published online February 11, 2013. doi:10.1001/jamapediatrics.2013.550.
The cortical thickness estimate for the right DLPFC was significantly reduced in PCE subjects compared with subjects with no PCE (mean [SD], 2.18 [0.15] vs 2.30 [0.14] mm; P = .03).
On the Sensation Seeking Scale for Children, more impulsivity was related to a larger thalamus in exposed subjects in both the PCE group (PCE: r = 0.47, P = .05; no PCE: r = 0.35, P = .14) and PTE group (PTE: r = 0.44, P = .04; no PTE: r = 0.22, P = .41).
Correlations between Conners’ Continuous Performance Test commission errors and caudate volume were of borderline significance in the PCE group (PCE: r = 0.44, P = .06; no PCE: r = −0.10, P = .68).
Contact Information significantly reduced in PCE subjects compared with subjects with no PCE (
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