Personalised medicine in Sweden

1. Personalised medicine in Sweden Mikael Benson, Centre for Personalised Medicine, Linköping University

2. Resources for Personalised Medicine (PM) in Sweden • Patient • Politicians • Clinicians • Ethics • Health Care • PM • Funders • Academia • National Resources • Industry • International Collaboration

3. Resources for Personalised Medicine (PM) in Sweden • Patients • Politicians • Clinicians • Ethics • Health Care • PM • Funders • Academia • National Resources • Industry • International Collaboration

4. Example from Multiple Sclerosis: Combinations of genetic, clinical and environmmental factors for PM Olsson T el al. Nature Rev Neurol (In press)

5. Drugs and life style changes for PM

6. Patients • Politicians • Clinicians • Ethics • Health Care • PM • Funders • Academia • National Resources • Industry • International Collaboration

7. Need for proofofconcept studies Projects that show clinical feasibility of PM in specific diseases within 3-5 years Analyses of health economics

8. Patients • Politicians • Clinicians • Ethics • Health Care • PM • Funders • Academia • National Resources • Industry • International Collaboration

9. Example from Linköping University/University Hospital

10. Centre for PersonalisedMedicine (CPMed), Linköping

11. Centre for PersonalisedMedicine (CPMed), Linköping

12. Ryhov County Hospital “Unselected” patients County Hospital conditions important for implementation • Futurum Academy for clinical research

13. Centre for PersonalisedMedicine (CPMed), Linköping • University Hospital • Medical faculty • Technicalfaculty • CPMed • Multi-disciplinary team: omics, bioinformatics, functional and clinical researchers • National and international collaborations • Industry

14. Regional investigationabout PM in East Gothia (Östergötland) • Are there diseases that are particularly suitable for implementation of PM within 3-5 years? • A health economics analysis for a regional effort towards PM

15. Resources for Personalised Medicine (PM) in Sweden • Patient • Politicians • Clinicians • Ethics • Health Care • PM • Funders • Academia • National Resources • Industry • International Collaboration

16. Industry Example from AstraZeneca

17. AstraZeneca 80 % of drug pipeline includes PM components Combining omics analyses of 2 million patients with clinical data to find subgroups and new targets Several collaborations with academia

18. Industry Diagnostics: biotech, biomarkers and software Health care industry

19. Big US companies are investing heavily in personalised medicine

20. Patients • Politicians • Clinicians • Ethics • Health Care • PM • Funders • Academia • National Resources • Industry • International Collaboration

21. National resources Population-wide registries Bioinformatics (BILS) • Biobanks (BBMRI) SciLife Lab National high performance computer

22. Funders Swedish Research Council Vinnova Swedish Foundation for Strategic Research Wallenberg Foundation

23. Example VR and Vinnovaarelaunching a National programme in protein research and biopharmaceuticaldrugs (320 millions SEK for 2016-2023)

24. Need for proofofconcept studies Projects that show clinical feasibility of PM in specific diseases within 3-5 years

25. Summary • PM already partially implemented in health care • All resources for general implementation are available in Sweden • Need for national coordination and dedicated funding for clinically oriented proof-of concept studies

27. Multi-Layered Disease Modules for Personalised medicine

30. Population-wide

31. Ideal • Equality in health care

32. Problem • Equality in health care ≠same care ?